Deficits in response inhibition associated with chronic methamphetamine abuse

Monterosso, John; Aron, Adam R.; Cordova, Xochitl; Xu, Jiansong; London, Edythe D.

doi:10.1016/j.drugalcdep.2005.02.002

Cited by 378 publications

(292 citation statements)

References 33 publications

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“…A total of 10 regions of interest (ROIs) were selected because of prior demonstrations of functional abnormalities associated with MA abuse: parietal cortex (Brodmann areas (BAs) 1,2,3,5,7,19,39,40), thalamus, dorsal striatum, ventral striatum, medial orbitofrontal cortex (gyrus rectus and medial orbital gyrus; BA 11), lateral orbitofrontal cortex (lateral, posterior orbital and inferior frontal gyri; BAs 47, 11), infragenual ACC (BAs 25, 32), supragenual ACC (BAs 24, 32, 33), insula (BA 13) and amygdala. 1,6,8,9 ROIs were drawn on the structural MR template provided in SPM2, using MEDx Software (Sensor Systems, Sterling, VA, USA).…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] These deficits appear to reflect regional cerebral dysfunction. When abstinent for 1 week, MA abusers studied with [F-18]fluorodeoxyglucose (FDG) and positron emission tomography (PET) have more severe self-reports of depressive symptoms than control subjects, and these self-reports covary with relative uptake of the radiotracer in anterior cingulate cortex (ACC) and amygdala.…”

Section: Introductionmentioning

confidence: 99%

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Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

et al. 2007

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Changes in brain function during the initial weeks of abstinence from chronic methamphetamine abuse may substantially affect clinical outcome, but are not well understood. We used positron emission tomography with [F-18]fluorodeoxyglucose (FDG) to quantify regional cerebral glucose metabolism, an index of brain function, during performance of a vigilance task. A total of 10 methamphetamine-dependent subjects were tested after 5-9 days of abstinence, and after 4 additional weeks of supervised abstinence. A total of 12 healthy control subjects were tested at corresponding times. Global glucose metabolism increased between tests (P = 0.01), more in methamphetamine-dependent (10.9%, P = 0.02) than control subjects (1.9%, NS). Glucose metabolism did not change in subcortical regions of methamphetaminedependent subjects, but increased in neocortex, with maximal increase ( > 20%) in parietal regions. Changes in reaction time and self-reports of negative affect varied more in methamphetamine-dependent than in control subjects, and correlated both with the increase in parietal glucose metabolism, and decrease in relative activity (after scaling to the global mean) in some regions. A robust relationship between change in self-reports of depressive symptoms and relative activity in the ventral striatum may have great relevance to treatment success because of the role of this region in drug abuse-related behaviors. Shifts in corticalsubcortical metabolic balance either reflect new processes that occur during early abstinence, or the unmasking of effects of chronic methamphetamine abuse that are obscured by suppression of cortical glucose metabolism that continues for at least 5-9 days after cessation of methamphetamine self-administration.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

et al. 2007

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“…cocaine, amphetamine, methamphetamine), and is also seen as a useful behavioural marker of genetic risk factors (Aron 2007;Aron and Poldrack 2005;Bellgrove et al 2006;Durston et al 2008;Fillmore et al , 2006Gauggel et al 2004;Monterosso et al 2005;Nigg et al 2004;Oosterlaan et al 1998;Penades et al 2007;Rubia et al 1998Rubia et al , 2005bRubia et al , 2007Schachar et al 2007;Schachar et al 1995;van den Wildenberg et al 2006). Indeed, impaired action inhibition is often considered as the core deficit in ADHD (e.g.…”

Section: The Unitary Concept Of 'Action Inhibition'mentioning

confidence: 99%

The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks

2008

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Background and rationale The term 'action inhibition' encapsulates the ability to prevent any form of planned physical response. Growing evidence suggests that different 'stages' or even subtypes of action inhibition activate subtly different neuropharmacological and neuroanatomical processes. Objectives In this review, we present evidence from two commonly used and apparently similar behavioural tests, the stop-signal task and the go/no-go task, to determine if these have similar neuroanatomical and neurochemical modulation. Results Whilst performance of the stop-signal and go/no-go tasks is modulated across only subtly different anatomical networks, serotonin (5-HT) is strongly implicated in inhibitory control on the go/no-go but not the stop-signal task, whereas the stop-signal reaction time appears more sensitive to the action of noradrenaline. Conclusions There is clear neuropharmacological and neuroanatomical evidence that stop-signal and go/no-go tasks represent different forms of action inhibition. This evidence translates with remarkable consistency across species. We discuss the possible implications of this evidence with respect to the development of novel therapeutic treatments for disorders in which inhibitory deficits are prominent and debilitating.

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“…Indeed, we have previously emphasized the face validity for impairments in the ability to stop or change ongoing responses for key psychopathological aspects of drug dependence and abuse (Jentsch and Taylor, 1999). For example, the abuse of addictive stimulant drugs is associated with profound impairments in tasks requiring changing or stopping responses (Monterosso et al, 2005), and notably, these same disorders are associated with substantial downregulations of the D 2 -like receptors in brain (Volkow et al, 1990(Volkow et al, , 1993(Volkow et al, , 2001. Our data provide evidence for a potential direct linkage between D 2 -like receptor function and the ability to modify behavior flexibly in response to a changing environment and suggest that effecting a net increase in D 2 -like receptor function in stimulant addicts may improve their ability to exert cognitive control over their own behavior in a manner that may immediately benefit their ability to quit.…”

Section: Implications For Mental Disordersmentioning

confidence: 99%

Dopamine D2/D3 Receptors Play a Specific Role in the Reversal of a Learned Visual Discrimination in Monkeys

Lee

Groman

London

et al. 2007

Neuropsychopharmacol

140

123

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Converging evidence supports a role for mesocorticolimbic dopaminergic systems in a subject's ability to shift behavior in response to changing stimulus-reward contingencies. To characterize the dopaminergic mechanisms involved in this function, we quantified the effects of subtype-specific dopamine (DA) receptor antagonists on acquisition, retention, and reversal of a visual discrimination task in nonhuman primates (Chlorocebus aethiops sabaeus). We used a modified Wisconsin General Test Apparatus that was equipped with three food boxes, each fitted with a lid bearing a unique visual cue; one of the cues concealed a food reward, whereas the other two concealed an empty box. The monkeys were trained first to acquire a novel discrimination (eg A + , B À , C À ) in a single session, before experiencing either a reversal of the discrimination (eg A À , B + , C À ) or the acquisition of a completely new discrimination (eg D + , E À , F À ), on the following day. Systemic administration of the D 2 /D 3 receptor antagonist raclopride (0.001-0.03 mg/kg) failed to significantly affect the performance of reversal learning when reversal sessions were run without a retention session. But, raclopride (0.03 mg/kg) significantly impaired performance under the reversal condition when reversal sessions were run right after a retention session; however, it did not affect acquisition of a novel visual discrimination. Specifically, raclopride significantly increased the number of reversal errors made before reaching the performance criterion in the reversal, but not in new learning sessions. In contrast, the D 1 /D 5 receptor antagonist SCH 23390 did not significantly modulate acquisition of a novel discrimination or reversal learning at doses (0.001-0.03 mg/kg, i.m.) that did not suppress behavior generally. In addition, none of the drug treatments affected retention of a previously learned discrimination. The results strongly suggest that D 2 /D 3 receptors, but not D 1 /D 5 receptors, selectively mediate reversal learning, without affecting the capacity to learn a new stimulus-reward association. These data support the hypothesis that phasic DA release, acting through D 2 -like receptors, mediates behavioral flexibility.

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Deficits in response inhibition associated with chronic methamphetamine abuse

Cited by 378 publications

References 33 publications

Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks

Dopamine D2/D3 Receptors Play a Specific Role in the Reversal of a Learned Visual Discrimination in Monkeys

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