Deficits in sustaining reward responses in subsyndromal and syndromal major depression

Liu, Wenhua; Chan, Raymond C. K.; Wang, Ling zhi; Huang, Jia; Cheung, Eric F.C.; Gong, Qi; Gollan, Jackie K.

doi:10.1016/j.pnpbp.2011.02.018

Cited by 76 publications

(78 citation statements)

References 42 publications

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“…Previous research on reward insensitivity has often found similar results in clinical and subclinical samples (e.g., Liu et al, 2011). Therefore, we are confident that the present findings can be generalized to patients with major depression.…”

Section: Discussionsupporting

confidence: 84%

“…Depressed and dysphoric individuals anticipate and experience less pleasure concerning a variety of activities and hedonic consequences, attribute lower value to rewards, and report weaker approach motivation (e.g., Dickson & MacLeod, 2006;Kasch, Rottenberg, Arnow, & Gotlib, 2002;MacPhillamy & Lewinsohn, 1974). On a behavioral level, depressed and dysphoric individuals fail to develop a response bias toward the rewarded or more frequently reinforced stimulus, fail to choose the options maximizing their winnings, and show deficits in reward-based decision making (e.g., Forbes, Shaw, & Dahl, 2007;Henriques & Davidson, 2000;Kunisato et al, 2012;Liu et al, 2011;Pizzagalli, Iosifescu, et al, 2009;Pizzagalli et al, 2005). Finally, a number of recent studies demonstrated reduced activity in cortical and subcortical components of the neural reward circuit of depressed and dysphoric individuals, both during anticipation and outcome phases of reward processing (e.g., Forbes et al, 2009;Knutson et al, 2008;Pizzagalli, Holmes, et al, 2009;Smoski et al, 2009;Steele, Kumar, & Ebmeier, 2007).…”

Section: Reward Insensitivity In Depression and Dysphoriamentioning

confidence: 99%

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Not everyone's heart contracts to reward: Insensitivity to varying levels of reward in dysphoria

Brinkmann

Franzén

2013

Biological Psychology

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Reward insensitivity in depression and dysphoria has been demonstrated by selfreport, behavioral, and neuroscience data. These findings show less anticipated and experienced pleasure to rewarding stimuli, no behavioral adaptation in anticipation of rewards, and altered functioning in reward-related brain areas. The present study expands previous research by using cardiovascular reactivity to three levels of reward as an indicator of effort mobilization. Undergraduates with low versus high depression scores worked on a cognitive task in anticipation of no, versus a small, versus a significant amount of money for successful task performance. Results of pre-ejection period and heart rate reactivity confirmed the expected linear increase as a function of reward value in nondysphoric participants and the expected blunted response across all reward levels in dysphoric participants. The present findings thus show that dysphoric individuals have a motivational deficit in terms of reduced effort-related cardiac reactivity when anticipating a monetary reward.

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Section: Discussionsupporting

confidence: 84%

Section: Reward Insensitivity In Depression and Dysphoriamentioning

confidence: 99%

Not everyone's heart contracts to reward: Insensitivity to varying levels of reward in dysphoria

Brinkmann

Franzén

2013

Biological Psychology

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“…First, our study is based on subclinical participants with high self-reported depression scores. Previous research on reward responsiveness has frequently found similar results in clinical and subclinical samples (e.g., Liu et al, 2011), including studies on effort-related cardiovascular response (Franzen and Brinkmann, 2016b;Franzen et al, 2016). Therefore, we are confident that the present findings can be generalized to clinically depressed patients.…”

Section: Limitations and Conclusionmentioning

confidence: 66%

“…The wealth of empirical studies strongly suggest that individuals with clinical and subclinical depression are impaired in their response to rewards both during the anticipatory (i.e., motivational) phase and during the consummatory (i.e., emotional) phase (for a detailed discussion about the distinction between these two phases, see Berridge and Robinson, 2003;Gard et al, 2006). Specifically, depressed individuals report less anticipated pleasure (e.g., Chentsova-Dutton and Hanley, 2010), show impaired reward-learning behavior (e.g., Huys et al, 2013;Liu et al, 2011;Vrieze et al, 2013), demonstrate impaired reward-related decision making (e.g., Kunisato et al, 2012;Treadway et al, 2012), have reduced activity in approach-related cortical regions (e.g., Shankman et al, 2013; for a review see Thibodeau et al, 2006), and show altered activity in reward-related brain regions (for a review see Zhang et al, 2013). Recently, we have shown reduced effort-related cardiovascular reactivity during goal pursuit in subclinical depression (Brinkmann and Franzen, 2013;Brinkmann et al, 2009;Brinkmann, 2015, 2016a).…”

Section: Reward Responsiveness In Depressionmentioning

confidence: 99%

Blunted cardiovascular reactivity during social reward anticipation in subclinical depression

Brinkmann

Franzén

2017

International Journal of Psychophysiology

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The present study extends past research about reduced reward responsiveness in depression by assessing effort-related cardiovascular responses during anticipation of a social reward. Dysphoric (i.e., subclinically depressed) and nondysphoric participants worked on a cognitive task. Half the participants in each group expected the possibility to subscribe to a social exchange internet site. Effort mobilization during task performance was assessed by participants' cardiovascular reactivity. Confirming the predictions, nondysphoric participants in the social-reward condition had higher reactivity of pre-ejection period, systolic blood pressure, and heart rate, compared to the other three cells. In contrast, dysphoric participants' cardiovascular reactivity was generally low. These findings indicate that social-reward function is indeed impaired in subclinical depression. Implications for social punishment are discussed.

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“…Depression scores on the Beck Depression Inventory (BDI-II; Beck et al, 1996) were 4.22 Ϯ 3.38 and 3.73 Ϯ 3.60 respectively, indicating an absence of depressive symptoms, and the scores did not differ statistically between the groups (t ϭ Ϫ0.34, p ϭ 0.74). We wished to exclude any participants with possible depression as the disorder is associated with significant alterations in emotional processing (Fales et al, 2008;Leppänen, 2006;Liu et al, 2011).…”

Section: Participantsmentioning

confidence: 99%

Healthy aging is associated with increased neural processing of positive valence but attenuated processing of emotional arousal: an fMRI study

Kehoe

Toomey²,

Balsters

et al. 2013

Neurobiology of Aging

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Arousal and valence play key roles in emotional perception, with normal aging leading to changes in the neural substrates supporting valence processing. The objective of this study was to investigate normal age-related changes in the neural substrates of emotional arousal processing. Twenty-three young and 23 older, healthy women underwent functional magnetic resonance imaging as they viewed images which were neutral or positive in valence and which varied in arousal level from low to high. Using a parametric modulation approach, we examined how the blood oxygen-level dependent signal varied with single trial subjective ratings of valence and arousal, and whether this differed with age. In accordance with previous studies we found that the older group showed greater activation in response to positive valence, in the left amygdala, left middle temporal gyrus and right lingual gyrus. In contrast however, they showed reduced reactivity to emotional arousal, in occipital and temporal visual cortices bilaterally, the left inferior parietal cortex, and the supplementary motor area bilaterally. This study represents the first of its kind to clearly dissociate how aging affects the neural correlates of emotional arousal and valence. The changes in arousal processing may in part be mediated by the functional reorganization evident in the aging brain, such as reduced activation of the posterior cortices as described by the posterior-anterior shift in ageing (PASA) effect.

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Deficits in sustaining reward responses in subsyndromal and syndromal major depression

Cited by 76 publications

References 42 publications

Not everyone's heart contracts to reward: Insensitivity to varying levels of reward in dysphoria

Not everyone's heart contracts to reward: Insensitivity to varying levels of reward in dysphoria

Blunted cardiovascular reactivity during social reward anticipation in subclinical depression

Healthy aging is associated with increased neural processing of positive valence but attenuated processing of emotional arousal: an fMRI study

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