Deficits of respiratory-cardiac coupling in heavy drinkers

Schulte, Tilman; Warzel, H.; Strasburger, Hans; Sabel, Bernhard A.

doi:10.1016/s0278-5846(01)00184-1

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…the acoustic heart rate response. Using this method in a previous study with drunken drivers, we found that decreased RSA and reduced acoustic heart rate response was related to the blood alcohol concentration (ranging from 0.16 to 0.31%) at the time of the offense [47]. The data suggest that individual alcohol tolerance level, obtained by continuous alcohol consumption over time, modulates the central influence on RSA.…”

Section: Introductionmentioning

confidence: 73%

“…Cardiac acceleration is often associated with sympathetic activity [15,17,54]. Still, a relative acceleration from the tone during a phase of absolute deceleration (expiration phase) as in our paradigm suggests a reduced vagal heart rate downregulation [47]. In the polyvagal theory [36] the vagal system is part of a feedback loop in which the central nervous system regulates cardiac output.…”

Section: Rsa With Auditory Stimulation In Healthy Subjects and The Rimentioning

confidence: 79%

“…Warzel and Krell [55] showed that the auditory effect on RSA is only present for stimulation in the early expiration phase, which may be interpreted as the efferent cardiac parasympathetic activity being either blocked or highly diminished during inspiration. For analyzing RSA we have chosen the time domain which allows analyzing the immediate cardiac response to acoustic stimulation [43,47,55]. The separation of inspiration and expiration phase which proves valuable to assess more central (medullar) control mechanisms amounts to a non-linear approach (a non-linearity in the respiration to heart rate transfer function) [9] that prohibits simple conversions between time and frequency domain analyses.…”

Section: Apparatusmentioning

confidence: 99%

“…It is well known that in heavy drinkers [47] and in chronic alcoholics [58], RSA is clearly reduced. In alcoholics, autonomic dysfunction and degeneration of the myelinated fibers in the vagal nerve have been observed [34].…”

Section: Rsa With Auditory Stimulation In Healthy Subjects and The Rimentioning

confidence: 99%

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Acute Moderate Alcohol Consumption Affects Cardiovascular Responses in Healthy Males with Different Tolerance Levels

Schulte¹,

Warzel²,

Westphal³

et al. 2002

Neuropsychobiology

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We investigated the effect of acute moderate alcohol consumption or placebo on respiratory sinus arrhythmia (RSA) in 48 healthy participants with different levels of alcohol tolerance but no abuse. In the electrocardiogram recording, auditory stimuli were presented at defined points in the respiratory cycle, which allows a non-invasive measure of CNS control over RSA. After alcohol consumption we found a decrease in RSA with auditory stimulation. Moreover, individuals with low tolerance showed only a slight change in the RSA after alcohol intake compared to baseline, whereas the placebo drink led to a reduced RSA. In subjects with high alcohol tolerance, alcohol consumption led to a reduction of RSA, with no change after placebo. These results suggest a centrally driven influence on RSA that is changed by alcohol ingestion depending upon subjects’ levels of alcohol tolerance.

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Section: Introductionmentioning

confidence: 73%

Section: Rsa With Auditory Stimulation In Healthy Subjects and The Rimentioning

confidence: 79%

Section: Apparatusmentioning

confidence: 99%

Section: Rsa With Auditory Stimulation In Healthy Subjects and The Rimentioning

confidence: 99%

See 2 more Smart Citations

Acute Moderate Alcohol Consumption Affects Cardiovascular Responses in Healthy Males with Different Tolerance Levels

Schulte¹,

Warzel²,

Westphal³

et al. 2002

Neuropsychobiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The degree of RSA is influenced by several factors, including age, respiration rate, tidal volume and a range of pathophysiologies (STRAUSS-BLASCHE et al, 2000;HRUSHESKY et al, 1984). The assessment of RSA has found clinical use as a measure of cardiac health in a variety of settings (SCHULTE et al, 2001;GLUCK et al, 2000;CASADEI et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Modulating effect of respiration on atrioventricular conduction time assessed using PR interval variation

Shouldice

Heneghan

Nolan

et al. 2002

Med. Biol. Eng. Comput.

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Respiratory sinus arrhythmia (RSA) is the variation of heart rate (or RR interval) in phase with respiration and has been extensively studied. However, the effect of respiration on atrioventricular conduction delay (and hence PR interval length) has not yet received much attention. This work reports on measurements of respiration and associated RR and PR variability, in 11 subjects, assessed through surface electrocardiogram measurements, for both paced and spontaneous respiration in the supine position. A wavelet-based approach was used to extract RR and PR intervals. The accuracy of RR and PR interval measurement was consistent with previously published work. Respiratory atrioventricular conduction delay variability (RCV) was assessed using three techniques: spectral, peak-to-trough and cosinor methods. All measures showed statistically significant variations in PR interval due to respiration during paced respiration at 6 min(-1). Of the three measures, cosinor analysis was most reliable in highlighting RCV. Using this measure, statistically significant RCV was seen in ten out of the 11 subjects during paced respiration. The magnitude of the variability was estimated as +/- 5.9% of the mean PR interval. In spontaneous respiration, statistically significant RCV was seen in approximately half of the subjects, with an estimated variability of +/- 1.5%. As a control, statistically significant values for RSA were also obtained from the same data, which agreed with previously published measurements. It was concluded that respiration does indeed modulate atrioventricular conduction delay, deep breathing in the supine position accentuates this effect, and cosinor analysis provides a reliable means for quantifying this effect.

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Alcohol and the Cardiovascular System: Implications for Behavioral Medicine

Lovallo¹

2022

Handbook of Cardiovascular Behavioral Medicine

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Deficits of respiratory-cardiac coupling in heavy drinkers

Cited by 6 publications

References 32 publications

Acute Moderate Alcohol Consumption Affects Cardiovascular Responses in Healthy Males with Different Tolerance Levels

Acute Moderate Alcohol Consumption Affects Cardiovascular Responses in Healthy Males with Different Tolerance Levels

Modulating effect of respiration on atrioventricular conduction time assessed using PR interval variation

Alcohol and the Cardiovascular System: Implications for Behavioral Medicine

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