2023
DOI: 10.1073/pnas.2304288120
|View full text |Cite
|
Sign up to set email alerts
|

Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling

James R. W. Conway,
Aleksi Isomursu,
Gautier Follain
et al.

Abstract: Integrin-dependent adhesion to the extracellular matrix (ECM) mediates mechanosensing and signaling in response to altered microenvironmental conditions. In order to provide tissue- and organ-specific cues, the ECM is composed of many different proteins that temper the mechanical properties and provide the necessary structural diversity. Despite most human tissues being soft, the prevailing view from predominantly in vitro studies is that increased stiffness triggers effective cell spreading and activation of … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2025
2025

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 9 publications
(1 citation statement)
references
References 69 publications
0
1
0
Order By: Relevance
“…The ECM comprises various major components, including collagen, proteoglycans, glycoproteins, fibronectin, laminin, and hyaluronic acid (HA) polysaccharides (as illustrated in Figure 1A). It is now realized that the composition and mechanical properties of the ECM impact the development and behavior of nearby cells 2 . A well-known example of the dramatic role of the ECM is in the context of cancer, where tumor tissues are characterized by a clear increase in ECM-related stiffness 3 .…”
Section: Introductionmentioning
confidence: 99%
“…The ECM comprises various major components, including collagen, proteoglycans, glycoproteins, fibronectin, laminin, and hyaluronic acid (HA) polysaccharides (as illustrated in Figure 1A). It is now realized that the composition and mechanical properties of the ECM impact the development and behavior of nearby cells 2 . A well-known example of the dramatic role of the ECM is in the context of cancer, where tumor tissues are characterized by a clear increase in ECM-related stiffness 3 .…”
Section: Introductionmentioning
confidence: 99%