Defining a molecular portrait of physical fitness

Clouse, Adam; Deo, Sapna K.; Rampersaud, Evadnie; Farmer, J; Goldschmidt‐Clermont, Pascal J.; Daunert, Sylvia

doi:10.1007/s00216-012-6533-2

Cited by 2 publications

(2 citation statements)

References 47 publications

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“…In participants with uterine fibroids, there was no difference in the mean uterine volume between African American and non-African American women with fibroids. A higher rate of early pregnancy loss in African American women (compared to Caucasian women) has been previously reported following IVF (36, 37). However, these studies analyzed pregnancy outcomes from the national assisted reproductive technologies registry, Society of Assisted Reproductive Technologies-Clinic Outcomes Reporting System, which does not specifically record data for fibroids.…”

Section: Discussionmentioning

confidence: 68%

Association of uterine fibroids and pregnancy outcomes after ovarian stimulation–intrauterine insemination for unexplained infertility

Styer

Jin

Liú

et al. 2017

Fertility and Sterility

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Objective To investigate the association of non-cavity distorting uterine fibroids and pregnancy outcomes following ovarian stimulation-intrauterine insemination (OS-IUI) in couples with unexplained infertility. Design Secondary analysis from a prospective, randomized, multicenter clinical trial investigating fertility outcomes following OS-IUI. Setting Reproductive Medicine Network clinical sites Patients Nine-hundred couples with unexplained infertility who participated in the Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) clinical trial. Intervention Participants were randomized to one of three arms (clomiphene citrate, letrozole, or gonadotropins) and treatment was continued for up to four cycles or until pregnancy was achieved. Main outcomes measures Conception (serum hCG increase), clinical pregnancy (fetal cardiac activity), and live birth rates. Results 102/900(11.3%) participants had at least one documented fibroid and a normal uterine cavity. Women with fibroids were older, more likely to be African American, had a greater uterine volume, lower serum anti-Mullerian hormone levels, and fewer antral follicles than women without fibroids. In conception cycles, clinical pregnancy rates were significantly lower in participants with fibroids than those without uterine fibroids. Pregnancy loss prior to 12-weeks was more likely in African American women with fibroids compared to non-African American women with fibroids. There was no difference in conception and live birth rates in subjects with and without fibroids respectively. Conclusions No differences were observed in conception and live birth rates in women with non-cavity distorting fibroids and those without fibroids. These findings provide reassurance that pregnancy success is not impacted in couples with non-cavity distorting fibroids undergoing OS-IUI for unexplained infertility.

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Section: Discussionmentioning

confidence: 68%

Association of uterine fibroids and pregnancy outcomes after ovarian stimulation–intrauterine insemination for unexplained infertility

Styer

Jin

Liú

et al. 2017

Fertility and Sterility

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“…From the smell and colour of urine as a tool for disease diagnosis [ 1 ] to the elusive promise of an “exercise pill” as a preventative measure of disease [ 2 , 3 ], could this be the future of health prescription? How could exercise, with its multi-factorial and multi-organ health benefits [ 2 , 4 , 5 , 6 , 7 ], be successfully administrated as an oral medication? If this theoretical pill existed, it would have to replicate the downstream metabolic effects of a single type of exercise tailored specifically to each unique metabolome or even metabotype [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

A Study of the Effects of Exercise on the Urinary Metabolome Using Normalisation to Individual Metabolic Output

et al. 2015

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Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology. We conducted an exploratory untargeted liquid chromatography mass spectrometry study to investigate the effects of a one-h aerobic exercise session in the urine of three physically active males. Individual urine samples were collected over a 37-h protocol (two pre-exercise and eight post-exercise). Raw data were subjected to a variety of normalization techniques, with the most effective measure dividing each metabolite by the sum response of that metabolite for each individual across the 37-h protocol expressed as a percentage. This allowed the metabolite responses to be plotted on a normalised scale. Our results highlight significant metabolites located in the following systems: purine pathway, tryptophan metabolism, carnitine metabolism, cortisol metabolism, androgen metabolism, amino acid oxidation, as well as metabolites from the gastrointestinal microbiome. Many of the significant changes observed in our pilot investigation mirror previous research studies, of various methodological designs, published within the last 15 years, although they have never been reported at the same time in a single study.

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Defining a molecular portrait of physical fitness

Cited by 2 publications

References 47 publications

Association of uterine fibroids and pregnancy outcomes after ovarian stimulation–intrauterine insemination for unexplained infertility

Association of uterine fibroids and pregnancy outcomes after ovarian stimulation–intrauterine insemination for unexplained infertility

A Study of the Effects of Exercise on the Urinary Metabolome Using Normalisation to Individual Metabolic Output

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