Defining atherosclerotic plaque biology by mass spectrometry-based omics approaches

Chandran, Mahesh; Sudhina, S.; Abhirami,; Chandran, Akash M.; Jaleel, Abdul; Ayyappan, Janeesh Plakkal

doi:10.1039/d2mo00260d

Cited by 5 publications

(1 citation statement)

References 149 publications

(167 reference statements)

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“…Atherogenesis begins with the accumulation of lipoproteins, in particular LDL in the subendothelial space [ 13 , 14 ]. In the inner intimal layer, oxidized LDL act as the chronic stimulators of innate and adaptive immune responses [ 11 , 15 ], while activated ECs and vascular smooth muscle cells (VSMCs) express adhesion molecules, chemoattractants and growth factors interacting with monocyte receptors, stimulating their homing, migration and differentiation into macrophages and dendritic cells [ 13 ].…”

Section: Pathophysiology Of Coronary Atherosclerotic Diseasementioning

confidence: 99%

Intracoronary Imaging of Coronary Atherosclerotic Plaque: From Assessment of Pathophysiological Mechanisms to Therapeutic Implication

Gurgoglione

Denegri

Russo

et al. 2023

IJMS

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Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality worldwide. Several cardiovascular risk factors are implicated in atherosclerotic plaque promotion and progression and are responsible for the clinical manifestations of coronary artery disease (CAD), ranging from chronic to acute coronary syndromes and sudden coronary death. The advent of intravascular imaging (IVI), including intravascular ultrasound, optical coherence tomography and near-infrared diffuse reflectance spectroscopy has significantly improved the comprehension of CAD pathophysiology and has strengthened the prognostic relevance of coronary plaque morphology assessment. Indeed, several atherosclerotic plaque phenotype and mechanisms of plaque destabilization have been recognized with different natural history and prognosis. Finally, IVI demonstrated benefits of secondary prevention therapies, such as lipid-lowering and anti-inflammatory agents. The purpose of this review is to shed light on the principles and properties of available IVI modalities along with their prognostic significance.

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Section: Pathophysiology Of Coronary Atherosclerotic Diseasementioning

confidence: 99%

Intracoronary Imaging of Coronary Atherosclerotic Plaque: From Assessment of Pathophysiological Mechanisms to Therapeutic Implication

Gurgoglione

Denegri

Russo

et al. 2023

IJMS

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Preliminary study of metabonomic changes during the progression of atherosclerosis in miniature pigs

Jia,

Zhao,

Niu

et al. 2024

Anim Models and Exp Med

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BackgroundTo explore potential biomarkers for early diagnosis of atherosclerosis (AS) and provide basic data for further research on AS, the characteristics of serum metabolomics during the progression of AS in mini‐pigs were observed dynamically.MethodsAn AS model in Bama miniature pigs was established by a high‐cholesterol and high‐fat diet. Fasting serum samples were collected monthly for metabolomics and serum lipid detection. At the end of the treatment period, pathological analysis of the abdominal aorta and coronary artery was performed to evaluate the lesions of AS, thereby distinguishing the susceptibility of mini‐pigs to AS. The metabolomics was detected using a high‐resolution untargeted metabolomic approach. Statistical analysis was used to identify metabolites associated with AS susceptibility.ResultsBased on pathological analysis, mini‐pigs were divided into two groups: a susceptible group (n = 3) and a non‐susceptible group (n = 6). A total of 1318 metabolites were identified, with significant shifting of metabolic profiles over time in both groups. Dynamic monitoring analysis highlighted 57 metabolites that exhibited an obvious trend of differential changes between two groups with the advance of time. The KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analysis indicated significant disorders in cholesterol metabolism, primary bile acid metabolism, histidine metabolism, as well as taurine and hypotaurine metabolism.ConclusionsDuring the progression of AS in mini‐pigs induced by high‐cholesterol/high‐fat diet, the alterations in serum metabolic profile exhibited a time‐dependent pattern, accompanied by notable disturbances in lipid metabolism, cholesterol metabolism, and amino acid metabolism. These metabolites may become potential biomarkers for early diagnosis of AS.

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TET protein inhibitors: Potential and limitations

Kaplánek,

Kejík,

Hajduch

et al. 2023

Biomedicine & Pharmacotherapy

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Defining atherosclerotic plaque biology by mass spectrometry-based omics approaches

Abstract: Atherosclerosis is the principal cause of vascular diseases and one of the leading causes of worldwide death. Even though several insights on its natural course, risk factors and interventions have...

Cited by 5 publications

References 149 publications

Intracoronary Imaging of Coronary Atherosclerotic Plaque: From Assessment of Pathophysiological Mechanisms to Therapeutic Implication

Intracoronary Imaging of Coronary Atherosclerotic Plaque: From Assessment of Pathophysiological Mechanisms to Therapeutic Implication

Preliminary study of metabonomic changes during the progression of atherosclerosis in miniature pigs

TET protein inhibitors: Potential and limitations

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