2024
DOI: 10.3389/fimmu.2023.1306292
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Defining genetic diversity of rhesus macaque Fcγ receptors with long-read RNA sequencing

Haleigh E. Conley,
Max M. He,
David Easterhoff
et al.

Abstract: Fcγ receptors (FcγRs) are membrane-bound glycoproteins that bind to the fragment crystallizable (Fc) constant regions of IgG antibodies. Interactions between IgG immune complexes and FcγRs can initiate signal transduction that mediates important components of the immune response including activation of immune cells for clearance of opsonized pathogens or infected host cells. In humans, many studies have identified associations between FcγR gene polymorphisms and risk of infection, or progression of disease, su… Show more

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