Defining imaging sub-phenotypes of psoriatic arthritis: integrative analysis of imaging data and gene expression in a PsA patient cohort

Eder, Lihi; Li, Quan; Rahmati, Sara; Rahman, Proton; Jurišica, Igor; Chandran, Vinod

doi:10.1093/rheumatology/keac078

Cited by 6 publications

(1 citation statement)

References 35 publications

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“…Early diagnosis, comprehensive disease assessment, and proper treatment are the mainstays to guarantee the best outcome of PsA patients, both in the short and long-term. In the past two decades, relevant research progresses have been made in understanding pathophysiology and defining clinical phenotypes (6)(7)(8)(9)(10)(11), and therapies targeting new mechanisms of action have been developed (12). Despite these improvements, the management of PsA is still difficult and many unresolved questions in this field await an answer (13).…”

Section: Introductionmentioning

confidence: 99%

Management of psoriatic arthritis: a consensus opinion by expert rheumatologists

D’Angelo,

Atzeni,

Benucci

et al. 2023

Front. Med.

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BackgroundPsoriatic arthritis (PsA) is a chronic inflammatory musculoskeletal disease involving several articular and extra-articular structures. Despite the important progresses recently made in all of the aspects of this disease, its management is still burdened by unresolved issues. The aim of this exercise was to provide a set of statements that may be helpful for the management of PsA.MethodsA group of 38 Italian rheumatologists with recognized expertise in PsA selected and addressed the following four topics: “early PsA,” “axial-PsA,” “extra-articular manifestations and comorbidities,” “therapeutic goals.” Relevant articles from the literature (2016–2022) were selected by the experts based on a PubMed search. A number of statements for each topic were elaborated.ResultsNinety-four articles were selected and evaluated, 68 out of the 1,114 yielded by the literature search and 26 added by the Authors. Each of the four topic was subdivided in themes as follows: transition from psoriasis to PsA, imaging vs. CASPAR criteria in early diagnosis, early treatment for “early PsA”; axial-PsA vs. axialspondyloarthritis, diagnosis, clinical evaluation, treatment, standard radiography vs. magnetic resonance imaging for “axial PsA”; influence of inflammatory bowel disease on the therapeutic choice, cardiovascular comorbidity, bone damage, risk of infection for “comorbidities and extra-articular manifestations”; target and tools, treat-to-target strategy, role of imaging for “therapeutic goals.” The final document consisted of 49 statements.DiscussionThe final product of this exercise is a set of statements concerning the main issues of PsA management offering an expert opinion for some unmet needs of this complex disease.

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Section: Introductionmentioning

confidence: 99%

Management of psoriatic arthritis: a consensus opinion by expert rheumatologists

D’Angelo,

Atzeni,

Benucci

et al. 2023

Front. Med.

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Integrative Computational Biology, AI, and Radiomics: Building Explainable Models by Integration of Imaging, Omics, and Clinical Data

Jurisica

2022

Artificial Intelligence/Machine Learning in Nuclear Medicine and Hybrid Imaging

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Association between musculoskeletal sonographic features and response to treatment in patients with psoriatic arthritis

Gutierrez,

Thib,

Koppikar

et al. 2024

RMD Open

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ObjectiveTo investigate the association between musculoskeletal sonographic features and clinical features, as well as treatment outcomes, in patients with active psoriatic arthritis (PsA).MethodsA prospective cohort study was conducted involving patients with active PsA. Disease activity was assessed clinically at baseline and 3–6 months after initiating therapy, with a Disease Activity Index for PsA (DAPSA) score calculated. A baseline ultrasound examination of 64 joints, 28 tendons and 16 entheses evaluated the following lesions: synovitis, peritenonitis, enthesitis, tenosynovitis, new bone formation and erosions. Total scores for each lesion and total inflammatory and structural scores were calculated. The association between baseline sonographic scores and treatment outcomes was assessed using Cox proportional hazards models (for drug persistence) and generalised estimating equation models for DAPSA change.ResultsA total of 135 treatment periods (107 patients) were analysed. Multivariable analysis showed that a greater reduction in DAPSA score at follow-up was associated with higher baseline synovitis (β −3.89), peritenonitis (β −3.93) and enthesitis structural scores (β −2.91). Additionally, the total inflammatory score independently predicted DAPSA change (β −5.23) regardless of the total structural damage score. Drug persistence was analysed in 105 treatment periods, revealing that a higher sonographic erosion score was associated with earlier drug discontinuation (adjusted HR 1.28, 95% CI 1.03 to 1.61).ConclusionThe study results provide preliminary evidence supporting the utility of musculoskeletal ultrasound in predicting treatment response and drug persistence in PsA.

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Defining imaging sub-phenotypes of psoriatic arthritis: integrative analysis of imaging data and gene expression in a PsA patient cohort

Cited by 6 publications

References 35 publications

Management of psoriatic arthritis: a consensus opinion by expert rheumatologists

Management of psoriatic arthritis: a consensus opinion by expert rheumatologists

Integrative Computational Biology, AI, and Radiomics: Building Explainable Models by Integration of Imaging, Omics, and Clinical Data

Association between musculoskeletal sonographic features and response to treatment in patients with psoriatic arthritis

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