Defining Incidence of Acute Compartment Syndrome in the Research Setting: A Proposed Method From the PACS Study

Leroux, Andrew; Frey, Katherine; Crainiceanu, Ciprian M.; Obremskey, William T.; Stinner, Daniel J.; Bosse, Michael J.; Karunakar, Madhav A.; O’Toole, Robert V.; Carroll, Eben A.; Hak, David J.; Hayda, Roman A.; Alkhoury, Dana; Schmidt, Andrew H.

doi:10.1097/bot.0000000000002284

Cited by 1 publication

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“…15 (3) The use of expert panel adjudication to identify which patients did or did not have ACS produced different results than did performance of fasciotomy, suggesting that expert panel consensus may be a new "benchmark" for confirming diagnosis of ACS for research. 16 Predicting Acute Compartment Syndrome II-Tissue Ultrafiltration Study Tissue ultrafiltration using small-diameter porous catheters could be a potential therapy because the intracompartment mass is reduced by the removal of fluid, potentially reducing intracompartment pressure. After completing the PACS study, METRC received funding for a 200-patient pending RCT to validate tissue ultra-filtrationTUF to prevent ACS.…”

Section: Prevent Clot Studymentioning

confidence: 99%

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The Major Extremity Trauma Research Consortium: Development and Impact of an Orthopaedic Trauma Research Program

2023

J Am Acad Orthop Surg

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The Major Extremity Trauma Research Consortium (METRC) is a unique and ongoing military-civilian collaboration that resulted in the largest orthopaedic trauma research enterprise to date. The Consortium was established in September 2009 with funding from the Department of Defense. It employs a centralized data coordinating center and has grown into a network of nearly 400 investigators at 70 clinical centers. METRC conducts large multicenter clinical research studies selected and designed to improve outcomes among severely injured military and civilian patients with extremity trauma. Over the past decade, the consortium has implemented 35 such studies distributed among 19 principal investigators, enrolled more than 23,000 patients, published 61 articles, and received more than $150 million in funding from the Department of Defense, Patient Centered Outcomes Research Institute, and National Institutes of Health. This unique multidisciplinary research platform is a powerful community capable of addressing the challenging issues related to the evaluation, treatment, and recovery after severe extremity trauma. This body of work received the 2023 Elizabeth Winston Lanier Kappa Delta Award. An overview of the METRC development, organization, and research focus areas is presented.

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Section: Prevent Clot Studymentioning

confidence: 99%

Section: Research Focus Areasmentioning

confidence: 99%

The Major Extremity Trauma Research Consortium: Development and Impact of an Orthopaedic Trauma Research Program

2023

J Am Acad Orthop Surg

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show abstract

Defining Incidence of Acute Compartment Syndrome in the Research Setting: A Proposed Method From the PACS Study

Abstract: To compare the retrospective decision of an expert panel who assessed likelihood of acute compartment syndrome (ACS) in a patient with a high-risk tibia fracture with decision to perform fasciotomy.

Cited by 1 publication

References 41 publications

The Major Extremity Trauma Research Consortium: Development and Impact of an Orthopaedic Trauma Research Program

The Major Extremity Trauma Research Consortium: Development and Impact of an Orthopaedic Trauma Research Program

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