Defining Long-Term Survivors Following Resection of Intrahepatic Cholangiocarcinoma

Bagante, Fabio; Spolverato, Gaya; Weiss, Matthew J.; Alexandrescu, Sorin; Marques, Hugo P.; Aldrighetti, Luca; Maithel, Shishir K.; Pulitano, Carlo; Bauer, Todd W.; Shen, Feng; Poultsides, George A.; Soubrane, O.; Martel, Guillaume; Koerkamp, Bas Groot; Guglielmi, Alfredo; Endo, Itaru; Pawlik, Timothy M.

doi:10.1007/s11605-017-3550-7

Cited by 35 publications

(16 citation statements)

References 42 publications

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“…21 The clinical outcomes of patients following liver resection for ICC are, however, highly variable. [22][23][24] The AJCC/UICC staging manual andto a lesser extentthe LCSGJ staging system are generally the most commonly utilized means to stratify patients following surgery for ICC. 9,25 Interestingly, both staging systems are relatively new, having been introduced only 20 years ago.…”

Section: Discussionmentioning

confidence: 99%

Serum tumor markers enhance the predictive power of the AJCC and LCSGJ staging systems in resectable intrahepatic cholangiocarcinoma

Sasaki

Margonis

Andreatos

et al. 2018

HPB

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Section: Discussionmentioning

confidence: 99%

Serum tumor markers enhance the predictive power of the AJCC and LCSGJ staging systems in resectable intrahepatic cholangiocarcinoma

Sasaki

Margonis

Andreatos

et al. 2018

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“…It is notable that the incidence rate of ICC, a rare form of liver cancer, has been rising globally over the past twenty years, which may reflect both a true increase and more accurate diagnosis of the disease (Massarweh & El-Serag 2017;Zhang et al 2016). Additionally, ICC is still a poorly understood malignancy that is strongly characterized by its poor prognosis (Bagante et al 2017;Beal et al 2018). Although scholars have revealed that some conventional medical interventions, such as adjuvant chemotherapy, antiviral therapy, and anatomical resection, might improve the prognosis of ICC patients to some extent, the 5-year OS rate is still only 40% (Lei et al 2018;Schweitzer et al 2017;Si et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Peer Review #2 of "The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinoma (v0.2)"

2020

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Ubiquitin-conjugating enzyme E2T (UBE2T) is overexpressed in several types of malignancies. However, little is known about its diagnostic significance in intrahepatic cholangiocarcinoma (ICC) and other bile duct diseases or its prognostic value in ICC. Methods: The expression levels of UBE2T in the intrahepatic bile duct (IHBD, N=13), biliary intraepithelial neoplasia (BilIN; BilIN-1/2, N=23; BilIN-3, N=11), and ICC (N=401) were examined by immunohistochemistry. The differential diagnostic and prognostic values were also assessed. Results: The number of UBE2T-positive cells was significantly higher in ICC tissues than in nonmalignant tissues, including the IHBD, BilIN-1/2, and BilIN-3 tissues. Kaplan-Meier analysis showed that overexpression of UBE2T was correlated with a shorter time to recurrence (TTR) and overall survival (OS). The 5-year TTR rates in the high UBE2T and low UBE2T groups were 100% and 86.2%, respectively. The corresponding OS rates were 1.9% and 22.2%, respectively. High expression of UBE2T was an independent risk factor for both TTR (hazard ratio: 1.345; 95% confidence interval: 1.047,1.728) and OS (hazard ratio: 1.420; 95% confidence interval: 1.098,1.837). Conclusions: UBE2T can assist in differentiating benign bile duct diseases from ICC, and high expression of UBE2T suggests a poor prognosis for ICC.

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“…According to previous studies, CCA cure is rare, with a 5-year survival ranging from 5% in intrahepatic CCA(iCCA) to 17% in extrahepatic CCA (Squadroni et al, 2017). Factors associated with survival rate of CCA after surgery include tumor size, number of tumors, lymph node metastasis, perineural invasion (PNI), lympho-vascular invasion (LVI) and marginal status (Yamamoto and Ariizumi, 2011;Song et al, 2013;Hartog et al, 2016;Bagante et al, 2017;Jeong et al, 2017;Squadroni et al, 2017;Wellner et al, 2017). However, most of these studies were done in developed countries where the natural history of CCA and its treatment may differ from those in developing countries where there are other causative factors, such as infection with the liver fluke, Opisthorchis viverrini.…”

Section: Survival Of Patients With Cholangiocarcinoma Receiving Surgimentioning

confidence: 99%

Survival of Patients with Cholangiocarcinoma Receiving Surgical Treatment in an O. viverrini Endemic Area in Thailand: A Retrospective Cohort Study

Chansitthichok

Chamnan

Sarkhampee

et al. 2020

Asian Pac J Cancer Prev

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Objective: To investigate risk factors associated with mortality in cholangiocarcinoma patients receiving surgical treatment in Thailand's endemic area and their survival rate. Materials and Methods: Medical records of patients with histologically confirmed cholangiocarcinoma, who underwent surgical treatment at Sanpasitthiprasong Regional Hospital from October 1, 2013 to October, 31 2015, were retrospectively included. Patients' vital status (death/alive) and date of death were obtained from the Interior Ministry's death certificate. Cox proportional hazard regression was used to examine factors associated with mortality. Results: Out of 295 patients with cholangiocarcinoma (CCA), 180(58%) were intrahepatic CCA, 86(28%) were perihilar CCA, and 29 (9%) were distal CCA. Three groups were homogenous in terms of age and gender. Most of our patients referred with abdominal pain (63%), especially those who were intrahepatic CCA (77%). However, almost 80% of the perihilar CCA and distal CCA patients came with jaundice. Tumor markers (CEA and CA19-9) were not different between groups p=0.74 and p=0.43 respectively. Median survival of patients with intrahepatic CCA, perihilar CCA, and distal CCA patients was 14.6, 14.2, and 14.0 months, respectively. Factors independently associated with mortality in intrahepatic CCA patients were number and size of tumors and presence of perineural invasion (Hazard ratio (HR) 1.

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Defining Long-Term Survivors Following Resection of Intrahepatic Cholangiocarcinoma

Abstract: While ICC is generally associated with a poor prognosis, some patients will be LT. In fact, even a subset of patients with traditional adverse prognostic factors survived long term.

Cited by 35 publications

References 42 publications

Serum tumor markers enhance the predictive power of the AJCC and LCSGJ staging systems in resectable intrahepatic cholangiocarcinoma

Serum tumor markers enhance the predictive power of the AJCC and LCSGJ staging systems in resectable intrahepatic cholangiocarcinoma

Peer Review #2 of "The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinoma (v0.2)"

Survival of Patients with Cholangiocarcinoma Receiving Surgical Treatment in an O. viverrini Endemic Area in Thailand: A Retrospective Cohort Study

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