Objective-Evidence is steadily accumulating that a preventable environmental hazard, child maltreatment, exerts causal influences on the development of long-standing patterns of antisocial behavior in humans. The relationship between child maltreatment and antisocial outcome, however, has never previously been tested in a large-scale study in which official-reports (rather than familymember reports) of child abuse and neglect were incorporated, and genetic influences comprehensively controlled for.Method-We cross-referenced official-report data on child maltreatment from the Missouri Division of Social Services (DSS) with behavioral data from 4,432 epidemiologically-ascertained Missouri twins from the Missouri Twin Registry (MOTWIN). We performed a similar procedure for a clinically-ascertained sample of singleton children ascertained from families affected by alcohol dependence participating in the Collaborative Study on the Genetics of Alcoholism (COGA, n=428) in order to determine whether associations observed in the general population held true in an "enriched" sample at combined inherited and environmental risk for antisocial development.Results-For both the twin and clinical samples, additive effects (not interactive effects) of maltreatment and inherited liability on antisocial development were confirmed, and were highly statistically significant.Conclusions-Child maltreatment exhibited causal influence on antisocial outcome when controlling for inherited liability in both the general population and in a clinically-ascertained sample. Official-report maltreatment data represents a critical resource for resolving competing hypotheses on genetic and environmental causation of child psychopathology, and for assessing intervention outcomes in efforts to prevent antisocial development
KeywordsConduct Disorder; genetics; child abuse; administrative data; externalizing behavior We continue to be inspired by our memories of Henri Begleiter and Theodore Reich, founding PI and Co-PI of COGA, and also owe a debt of gratitude to other past organizers of COGA, including Ting-Kai Li, P. Michael Conneally, Raymond Crowe, and Wendy Reich, for their critical contributions.