Defining Pancreatitis as a Risk Factor for Pancreatic Cancer

Abstract

Objectives Acute and/or chronic pancreatitis has been implicated as an important risk factor for pancreatic cancer; however, the incidence and temporal relationship of pancreatitis before pancreatic cancer diagnosis are unclear. We aim to understand the role and incidence of pancreatitis temporally with the development of pancreatic cancer. Methods A population-based study was used to investigate a temporal relationship between pancreatitis and pancreatic cancer diagnoses. Intervals of 3, 6, 12, 24, and 36 months were developed. Demographical data including age, sex, and race were also recorded and analyzed. Results A total of 50,080 patients were found to have a diagnosis of pancreatic cancer, of which 7420 (14.8%) had prior diagnoses of pancreatitis. Of those, 92% were between the ages of 40 and 89 years. African Americans had a higher rate of pancreatitis before cancer diagnosis when compared with whites (21.2% vs 14.8%, P < 0.0001). Further analysis revealed that pancreatitis occurred in 81.3% of patients 3 months before a diagnosis of pancreas cancer and 98.9% had established diagnoses of pancreatic cancer within 3 years. Conclusions Screening of patients older than 40 years who have pancreatitis and unclear etiology of pancreatitis may be warranted, especially in African Americans and male individuals.

Pancreatic cancer: A review of epidemiology, trend, and risk factors

“…Mutations of susceptibility genes in chronic pancreatitis can determine hereditary pancreatitis, idiopathic chronic pancreatitis, and cystic fibrosis, and Cazacu et al [ 140 ] found that mutations of cystic fibrosis transmembrane conductance regulator ( CFTR ) genes modestly increase the risk of pancreatic cancer in a meta-analysis. A total of 50080 patients were diagnosed with pancreatic cancer, of which 14.8% (7420 cases) were diagnosed with idiopathic pancreatitis prior to the diagnosis of cancer[ 141 ]. After pancreatitis diagnosis, six risk factors significantly associated with pancreatic cancer diagnosis included age between 40 and 90 years, African-American race, male sex, smoking, obesity, and DM, suggesting that it may be warranted to screen patients older than 40 years with unclear etiology of pancreatitis, especially for African-Americans and male population[ 141 ].…”

“…A total of 50080 patients were diagnosed with pancreatic cancer, of which 14.8% (7420 cases) were diagnosed with idiopathic pancreatitis prior to the diagnosis of cancer[ 141 ]. After pancreatitis diagnosis, six risk factors significantly associated with pancreatic cancer diagnosis included age between 40 and 90 years, African-American race, male sex, smoking, obesity, and DM, suggesting that it may be warranted to screen patients older than 40 years with unclear etiology of pancreatitis, especially for African-Americans and male population[ 141 ].…”

Inflammatory-miR-301a circuitry drives mTOR and Stat3-dependent PSC activation in chronic pancreatitis and PanIN

“…A large cohort study reported that 14.8% patients with pancreatic cancer had a prior diagnoses of pancreatitis. 34 However, the relationship between pancreatitis and pancreatic cancer has not been completely elucidated. In the present study, we reveal a role for a pro-inflammatory miRNA, miR-301a, in pancreatitis and pancreatitis-associated PanIN, which are conditions known to accelerate the development of pancreatic ductal adenocarcinoma.…”

Descriptive, analytical and molecular epidemiology of pancreatic cancer

“…[31]. По данным A. Syed et al, панкреатит возник у 81,3 % пациентов за 3 мес до постановки диагноза РПЖ и у 98,9 % за 3 года [32]. Таким образом, исследователи пришли к выводу, что хронический панкреатит, как и сахарный диабет, может являться как фактором риска РПЖ, так и быть следствием РПЖ из-за возможной обструкции протоков опухолью и в данном случае может выступать в роли раннего маркера РПЖ.…”