Defining Subclinical Keratoconus Using Corneal First-Surface Higher-Order Aberrations

Characterization of corneal structure in keratoconus

“…[2][3][4][5][6]17,67,68 Higher amounts of vertical coma and larger values of coma-like root mean square (RMS) have been reported in patients with keratoconus or keratoconus suspect. [2][3][4][5][6]17,67 In 2006, the first keratoconus severity grading system that used the magnitude of anterior corneal coma-like aberrations as the main classifying criterion was developed (Table 3). 4 In 23 eyes with keratoconus, 10 eyes with subclinical keratoconus (keratoconus suspect by definition), and 127 controls, B€ uhren et al 17 evaluated the keratoconus detection ability of anterior corneal Figure 3.…”

“…The found the cutoff points of 0.555 (sensitivity 100%, specificity 98.4%) and 0.248 mm (sensitivity 100%, specificity 73.6%) for clinical and subclinical keratoconus, respectively. 17 In addition to anterior corneal aberrations, posterior corneal aberrometric data are useful for keratoconus diagnosis. 69,70 Nakagawa et al 69 found large amounts of primary coma in the anterior and posterior corneal surfaces (primary coma RMS anterior/posterior: 3.57/0.87 mm) in 28 keratoconic eyes, although coma from the posterior surface compensated partly for that from the anterior surface.…”

“…The term keratoconus suspect was coined for designating corneas not showing biomicroscopic keratoconic signs but subtle topographic features similar to early stages of keratoconus. [14][15][16][17][18][19] In such conditions, other diagnostic tests and examinations may be helpful to confirm the potential presence of an incipient ectatic condition.…”

“…[2][3][4][5][6]17,67 In 2006, the first keratoconus severity grading system that used the magnitude of anterior corneal coma-like aberrations as the main classifying criterion was developed (Table 3). 4 In 23 eyes with keratoconus, 10 eyes with subclinical keratoconus (keratoconus suspect by definition), and 127 controls, B€ uhren et al 17 evaluated the keratoconus detection ability of anterior corneal Figure 3. Tangential map of the posterior corneal surface obtained by the Pentacam Scheimpflug photography.…”

Queratocono: una revisión y posible situación epidemiológica en Colombia.

“…Los lentes de contacto ROSE-K rígidos fueron adaptados con éxito en el 100% de los casos de queratocono moderado y en el 96% de los queratoconos severos. El 90% de los casos reportaron comfort y la determinación de la curvatura axial corneal, por medio de la topografía es mucho mejor para determinar la curva base del lente final (43).…”