Defining Subsets of Patients With Chronic Bronchitis

Wilson, Robert; Wilson, C B

doi:10.1378/chest.112.6_supplement.303s

Cited by 19 publications

(7 citation statements)

References 34 publications

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“…Chronic bronchitis was defined as the presence of coughing or sputing on most days of three months or more, for over two years 9,10) . During physical examination, elongation of expirium, rhonchii in auscultation and wheezing were the pathologic signs in favour of airway disease.…”

Section: Ascertainment Of Respiratory Effectsmentioning

confidence: 99%

Oxidant‐Antioxidant Status and Pulmonary Function in Welding Workers

Fidan¹,

Ünlü²,

Köken³

et al. 2005

Journal of Occupational Health

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Oxidant-Antioxidant Status and Pulmonary Function in Welding Workers: Fatma FIDAN, et al. Department of Pulmonary Diseases, Turkey-Welding is a process during which fumes, gases, electromagnetic radiation and noise are emitted as by-products. Metal oxide particles are particularly hazardous components of welding fumes. Welding has been found to be associated with respiratory symptoms and our objective in the present study was to study the effects of welding on pulmonary function and serum oxidant-antioxidant status. Fifty-one welding workers and 31 control subjects were recruited. Face to face interviews were conducted using the respiratory illness questionnaire adapted from the American Thoracic S o c i e t y w i t h t h e a d d i t i o n o f d e m o g r a p h i c characteristics, work history and working conditions. Additionally physical examinations and spirometric measurements were performed at workplaces. Thiobarbituric acid reactive substances (TBARS), protein carbonyls, protein sulfhydryls (SH) and erythrocyte reduced glutathione (GSH) levels were measured to evaluate oxidant-antioxidant status in 34 welding workers and in 20 control subjects. No statistically significant differences were observed in age, height, weight, body mass index (BMI), smoking status and annual working durations between welding workers and controls. Coughing, sputing and wheezing were significantly higher in welding workers (p<0.05). When adjusted for age, BMI and smoking status in logistic regression, welding work showed a significant risk for chronic bronchitis (OR: 4.78, 95%CI: 1.30-17.54). Forced expiratory volume in one second (FEV 1 )/forced vital capacity (FVC) and four parameters of forced expiratory flow (FEF: FEF 25 , FEF 50 , FEF 75 , FEF 25-75 ) levels measured in the welding workers were significantly lower than those in the control group (p<0.05). Serum TBARS and protein carbonyl levels were higher in welding workers than those in controls (p<0.001, p<0.05, respectively). On the other hand, total protein SH groups and GSH levels were significantly lower in welders than those in controls (p<0.05, p<0.001, respectively). Pulmonary function tests and oxidant-antioxidant status were found to be negatively affected in welding workers chronically exposed to welding fumes and gases. Preventive measures should be taken to improve the health status of these workers. (J Occup Health 2005; 47: 286-292)

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Section: Ascertainment Of Respiratory Effectsmentioning

confidence: 99%

Oxidant‐Antioxidant Status and Pulmonary Function in Welding Workers

Fidan¹,

Ünlü²,

Köken³

et al. 2005

Journal of Occupational Health

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“…These conditions have been reviewed elsewhere and include cardiopulmonary disease, hypoxia, hypercapnia, long duration and severity of disease, mucus hypersecretion, frequent exacerbations and requirement for oral corticosteroid therapy [4,99,105,106]. The current American, European and British guidelines do not recommend any change in antibiotic policy, whereas the other three sets recommend first-line empirical therapy with an antibiotic that is active against resistant strains such as those producing beta-lactamase enzyme, and in some patients who have received frequent courses of antibiotics or also have chronic bronchial suppuration Gram-negative bacilli.…”

Section: Antibiotic Resistance and New Antibiotics For Treatment Of Lmentioning

confidence: 99%

Bacteria, antibiotics and COPD

Wilson

2001

Eur Respir J

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Bacterial infection is one of several important causes of exacerbations of chronic obstructive pulmonary disease (COPD) that may coexist. COPD is a heterogeneous condition and the incidence of bacterial infection is not uniform; mucus hypersecretion may be an important risk factor.The bacteriology of infections varies depending on the severity of the underlying airway disease. There is now a much better understanding of the pathogenesis of bacterial infections of the respiratory mucosa. Lower airway bacterial colonization may be a stimulus for chronic inflammation and may influence the interval between exacerbations.Antibiotic resistance has increased in all the major pathogens. Antibiotics are an important part of the treatment of acute exacerbations of COPD and the decision about whether to give an antibiotic can be made on clinical grounds. It is more difficult to decide, on the available evidence, whether patient characteristics and the risk of antibiotic resistance should influence choice of empiric antibiotic treatment.Most new antibiotics are modifications of existing structures, suggesting that every effort should be made to conserve the sensitivity of current antibiotics by using them appropriately.

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“…Chronic bronchitis was defined as presence of coughing or phlegm on most days lasting three months or more for over two years. [4][5][6] In the physical examination, the lengthening of expirium, rhonchii in auscultation, and wheezing were the pathologic signs indicative of airway disease. Airway disease was defined as chronic bronchitis and/or pathologic signs in auscultation and at least two respiratory symptoms and/or FEV 1 /FVC , 70% on spirometry.…”

Section: Ascertainment Of Respiratory Effectmentioning

confidence: 99%

“…Airway disease was defined as chronic bronchitis and/or pathologic signs in auscultation and at least two respiratory symptoms and/or FEV 1 /FVC , 70% on spirometry. [5][6][7] Statistical analysis The coffeehouse workers and the small shop owners were compared for baseline characteristics. Student's t test was performed to compare age, height, weight, BMI, and spirometric results.…”

Section: Ascertainment Of Respiratory Effectmentioning

confidence: 99%

Airway disease risk from environmental tobacco smoke among coffeehouse workers in Turkey

Fidan

Çımrın

Ergör³

et al. 2004

Tob Control

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Objectives: To examine the effect of ETS exposure on respiratory symptoms and pulmonary function and to compare workers in coffeehouses to those in other occupations in order to assess the risk of respiratory illness in this occupation. Design: Cross sectional study. Setting: The study area consisted of the three metropolitan districts of the city of Izmir, Turkey. 86 coffeehouses and 80 other small scale shops which had no known respiratory risk factor, located in the same area, were taken as the study group. Subjects: 207 workers were assessed. Main outcome measurements: Subjects answered a questionnaire about demographic and working characteristics, respiratory symptoms, and smoking behaviour. Physical examinations and spirometric measurements were carried out at the workplaces.Results: There was a significant increase in respiratory symptoms in coffeehouse workers. Working in a coffeehouse showed a significant risk for chronic bronchitis (odds ratio (OR) 4.3). In coffeehouse workers, forced expiratory volume in one second (FEV 1 ) decreased 5.1%, forced vital capacity (FVC) 3.4%, FEV 1 / FVC 1.6%, peak expiratory flow (PEF) 6.45%, and forced expiratory flow (FEF 25 ) 7.2%, FEF 50 10%, and FEF 25-75 9.8%. Among workers who were described as having an ''airway disease'', coffeehouse workers were significantly greater in number. When age, body mass index, and smoking behaviour were controlled, working in a coffeehouse was strongly associated with ''airway disease'' compared to other workers (OR 5.35, 95% confidence interval 2.41 to 11.87). Conclusions: Workers in coffeehouses showed significant increases in respiratory symptoms and decreased pulmonary function. All workers need to gain an awareness of these occupational risks and working conditions should be improved immediately.

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Defining Subsets of Patients With Chronic Bronchitis

Cited by 19 publications

References 34 publications

Oxidant‐Antioxidant Status and Pulmonary Function in Welding Workers

Oxidant‐Antioxidant Status and Pulmonary Function in Welding Workers

Bacteria, antibiotics and COPD

Airway disease risk from environmental tobacco smoke among coffeehouse workers in Turkey

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