Defining “successful” treatment outcomes in adolescent idiopathic scoliosis: a scoping review

Joarder, Ishraq; Taniguchi, Seika; Mendoza, Andrea; Snow, M. Elizabeth

doi:10.1007/s00586-023-07592-w

Cited by 4 publications

(2 citation statements)

References 178 publications

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“…Recognizing the inevitable variance in Cobb angle measurement, we referred to the most recent guidelines 21 established by Society on Scoliosis Orthopedic and Rehabilitation Treatment to define bracing success. These criteria have been consistently used in numerous published studies 21–27 …”

Section: Methodsmentioning

confidence: 99%

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Higher Baseline Serum Myokine of FSTL1 may Serve as a Potential Predictive Biomarker for Successful Brace Treatment in Girls with Adolescent Idiopathic Scoliosis

Feng

et al. 2023

Spine

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Study Design. A retrospective case-control study. Objective. This study aimed to investigate whether myokine, which is related to exercise and muscle mass, could serve as a biomarker for predicting bracing outcomes. Summary of Background Data. Several risk factors have been documented to be associated with bracing failure in patients with adolescent idiopathic scoliosis (AIS). However, serum biomarkers have not been extensively explored. Patients and Methods. Skeletally immature females with AIS, without previous histories of bracing or surgery, were included. Peripheral blood was collected at the time of the bracing prescription. Baseline serum concentrations of 8 myokines [apelin, fractalkine, brain-derived neurotrophic factor, erythropoietin, osteonectin, fatty-acid-binding protein 3, follistatin-like 1 (FSTL1), and musclin] were measured by multiplex assays. Patients were followed up until weaned from bracing and then designated as a “failure” (defined as Cobb angle progression >5°) or “success.” A logistic regression analysis was performed that accounted for serum myokines and skeletal maturity. Results. We included 117 patients, with 27 in the failure group. Patients in the failure group had lower initial Risser sign and lower baseline serum levels of myokines, including FSTL1 (2217.3 ± 617.0 vs. 1369.3 ± 704.9, P = 0.002), apelin [116.5 (12.0, 335.9) vs. 83.5 (10.5, 221.1), P = 0.016], fractalkine (979.6 ± 457.8 vs. 743.8 ± 456.1, P = 0.020), and musclin [211.3 (16.3, 370.3) vs. 67.8 (15.5, 325.6), P = 0.049]. Following adjusted analysis, serum FSTL1 [odds ratio = 10.460; (2.213–49.453)] was determined to be predictive of bracing effectiveness. Conclusion. Patients who failed AIS bracing had significantly lower mean baseline levels of FSTL1 than those who achieved success. FSTL1 may serve as a biomarker that can inform outcomes after bracing.

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Section: Methodsmentioning

confidence: 99%

“…These criteria have been consistently used in numerous published studies. [21][22][23][24][25][26][27]…”

Section: Study Design and Participantsmentioning

confidence: 99%

Higher Baseline Serum Myokine of FSTL1 may Serve as a Potential Predictive Biomarker for Successful Brace Treatment in Girls with Adolescent Idiopathic Scoliosis

Feng

et al. 2023

Spine

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Adolescent idiopathic scoliosis is associated with muscle area asymmetries in the lumbar spine

Becker,

Li,

Wang

et al. 2023

Eur Spine J

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Purpose While the etiopathogenesis of adolescent idiopathic scoliosis (AIS) remains unclear, it is assumed that muscular asymmetries contribute to curve progression. As previous studies have found asymmetries of the thoracic paraspinal muscles in AIS patients, our study’s aim was to analyze differences in the erector spinae, multifidus, quadratus lumborum, and psoas muscles of the lumbar spine depending on the curve’s radiographic characteristics. Methods We retrospectively included all patients who received posterior reposition spondylodesis for AIS treatment at our institution. Patients were classified according to the Lenke classification. Muscle cross-sectional areas were obtained from magnetic resonance imaging of the lumbar spine. Data were analyzed with the Wilcoxon rank sum test, the Kruskal–Wallis test with post hoc testing, or the Spearman’s correlation coefficient. Results Seventy-four (14 males and 60 females) AIS patients with a median age of 16 (IQR ± 4) years and a mean Cobb angle of 56.0° (± 18.0°) were included. In curve types Lenke 1 and 2 (n = 45), the erector spinae (p < 0.001) and multifidus (p < 0.001) muscles had a significantly larger cross-sectional area on the convex side, whereas the quadratus lumborum (p = 0.034) and psoas (p < 0.001) muscles each had a significantly larger cross-sectional area on the lumbar contralateral side. Conclusion Our results show an asymmetry of the lumbar spine’s muscles which depends on both the convexity and the extent of the scoliotic curve. While our results cannot prove whether these differences are the deformity’s cause or effect, they may contribute to a better understanding of AIS pathogenesis and may allow for more specific preoperative physiotherapy.

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Design and development of an intelligent wearing system for adolescent spinal orthotics

Xuan,

Lei,

Shao

et al. 2024

Med Biol Eng Comput

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Defining “successful” treatment outcomes in adolescent idiopathic scoliosis: a scoping review

Cited by 4 publications

References 178 publications

Higher Baseline Serum Myokine of FSTL1 may Serve as a Potential Predictive Biomarker for Successful Brace Treatment in Girls with Adolescent Idiopathic Scoliosis

Higher Baseline Serum Myokine of FSTL1 may Serve as a Potential Predictive Biomarker for Successful Brace Treatment in Girls with Adolescent Idiopathic Scoliosis

Adolescent idiopathic scoliosis is associated with muscle area asymmetries in the lumbar spine

Design and development of an intelligent wearing system for adolescent spinal orthotics

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