Defining Target Volumes for Stereotactic Ablative Radiotherapy of Early-stage Lung Tumours: A Comparison of Three-dimensional 18F-fluorodeoxyglucose Positron Emission Tomography and Four-dimensional Computed Tomography

Hanna, G.G.; Koste, John R. van Sörnsen de; Dahele, Max; Carson, K.J.; Haasbeek, Cornelis J.A.; Migchielsen, R.; Hounsell, Alan R.; Senan, Suresh

doi:10.1016/j.clon.2012.03.002

Cited by 28 publications

(29 citation statements)

References 36 publications

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“…Two different methods for doing this in practice have been established-(1) definition of the internal target volume (ITV) and (2) 21 The two methods take two quite different approaches to achieving the same goal-calculating an adequate CTV-to-PTV margin to account for the breathing motion observed in the 4DCT scan.…”

Section: Motion Management Strategiesmentioning

confidence: 99%

Image-guided radiotherapy and motion management in lung cancer

Korreman¹

2015

BJR

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In this review, image guidance and motion management in radiotherapy for lung cancer is discussed. Motion characteristics of lung tumours and image guidance techniques to obtain motion information are elaborated. Possibilities for management of image guidance and motion in the various steps of the treatment chain are explained, including imaging techniques and beam delivery techniques. Clinical studies using different motion management techniques are reviewed, and finally future directions for image guidance and motion management are outlined.

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Section: Motion Management Strategiesmentioning

confidence: 99%

Image-guided radiotherapy and motion management in lung cancer

Korreman¹

2015

BJR

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“…Analogously, Hanna et al [25] compared volumes from a manual method and five automated PET segmentation techniques to 4DCT-derived ITV and found that none of the PET target volumes approximated closely to the 4DCT target volumes. However, in their study, the patient’s PET/CT and 4DCT scans were not acquired on the same day or in identical position.…”

Section: Discussionmentioning

confidence: 99%

“…However, in their study, the patient’s PET/CT and 4DCT scans were not acquired on the same day or in identical position. In this circumstance, it was possible that changes in tumor geometry or size occurred and potentially increased the likelihood of a mismatch between the PET-based contours and the 4DCT-based contours [25]. Caldwell et al [16] reported that using a threshold as low as 15% of the maximum value could account for respiratory motion and more accurately depict the true extension of the moving target.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of primary target volumes delineated on four-dimensional CT and 18 F-FDG PET/CT of non-small-cell lung cancer

Duan

Zhang

et al. 2014

Radiat Oncol

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BackgroundTo determine the optimal threshold of 18 F-fluorodexyglucose (18 F-FDG) positron emission tomography CT (PET/CT) images that generates the best volumetric match to internal gross target volume (IGTV) based on four-dimensional CT (4DCT) images.MethodsTwenty patients with non-small cell lung cancer (NSCLC) underwent enhanced three-dimensional CT (3DCT) scan followed by enhanced 4DCT scan of the thorax under normal free breathing with the administration of intravenous contrast agents. A total of 100 ml of ioversol was injected intravenously, 2 ml/s for 3DCT and 1 ml/s for 4DCT. Then 18 F-FDG PET/CT scan was performed based on the same positioning parameters (the same immobilization devices and identical position verified by laser localizer as well as skin marks). Gross target volumes (GTVs) of the primary tumor were contoured on the ten phases images of 4DCT to generate IGTV10. GTVPET were determined with eight different threshold using an auto-contouring function. The differences in the position, volume, concordance index (CI) and degree of inclusion (DI) of the targets between GTVPET and IGTV10 were compared.ResultsThe images from seventeen patients were suitable for further analysis. Significant differences between the centric coordinate positions of GTVPET (excluding GTVPET15%) and IGTV10 were observed only in z axes (P < 0.05). GTVPET15%, GTVPET25% and GTVPET2.0 were not statistically different from IGTV10 (P < 0.05). GTVPET15% approximated closely to IGTV10 with median percentage volume changes of 4.86%. The best CI was between IGTV10 and GTVPET15% (0.57). The best DI of IGTV10 in GTVPET was IGTV10 in GTVPET15% (0.80).ConclusionNone of the PET-based contours had both close spatial and volumetric approximation to the 4DCT IGTV10. At present 3D-PET/CT should not be used for IGTV generation.

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“…Perfect overlap yields a Dice coefficient value of 100%, whereas no overlap yields value of 0%. It is calculated as follows:

Dice coefficient = \frac{2 \cdot normalN false(normalA \cap normalB false)}{normalN false(normalA false) + normalN false(normalB false)}

where N(A∩B) is the number of elements that intersect between set A and set B, N(A) is the number of elements in set A, and N(B) is the number of elements in set B [22]. …”

Section: Methodsmentioning

confidence: 99%

[ 18 F]Fluoro-2-deoxy-2- d -glucose versus 3′-deoxy-3′-[ 18 F]fluorothymidine for defining hematopoietically active pelvic bone marrow in gynecologic patients

Wyss

Carmona

Karunamuni

et al. 2016

Radiotherapy and Oncology

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Background and Purpose We compared [18F]fluoro-2-deoxy-2-D-glucose (FDG) versus 3′-deoxy-3′-[18F]fluorothymidine (FLT) for the purpose of identifying active pelvic bone marrow (BM), quantifying its locational variation, and determining which technique is likely to be better for BM-sparing radiation planning. Material and Methods We sampled 41 patients, of which 25 underwent FDG-PET/CT only, 7 underwent FLT-PET/CT only, and 9 underwent both. Active BM subvolumes were defined as subsets of the pelvic BM with the highest standardized uptake values comprising 40%, 50%, and 60% of the total pelvic BM volume. We used the Dice similarity coefficient to quantify the percent overlap of active BM volumes of equal size. Differences in the spatial distribution of active BM were assessed using a region-growing algorithm. Results For patients with both modalities, the mean Dice coefficients for the 40%, 50%, and 60% subvolumes were 0.683, 0.732, and 0.781 respectively. Comparing individual active BM subvolumes to the mean subvolume, Dice coefficients varied from 0.598–0.889 for FDG and 0.739–0.912 for FLT. Region growing analysis showed FLT-PET defined more highly clustered active BM subvolumes. Conclusions Within the limitations of a small sample size, we found significant agreement between FDG-PET and FLT-PET; however, FLT-PET had significantly less individual variation and is likely to be superior to FDG-PET for BM-sparing radiotherapy.

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Defining Target Volumes for Stereotactic Ablative Radiotherapy of Early-stage Lung Tumours: A Comparison of Three-dimensional 18F-fluorodeoxyglucose Positron Emission Tomography and Four-dimensional Computed Tomography

Cited by 28 publications

References 36 publications

Image-guided radiotherapy and motion management in lung cancer

Image-guided radiotherapy and motion management in lung cancer

Comparison of primary target volumes delineated on four-dimensional CT and 18 F-FDG PET/CT of non-small-cell lung cancer

[ 18 F]Fluoro-2-deoxy-2- d -glucose versus 3′-deoxy-3′-[ 18 F]fluorothymidine for defining hematopoietically active pelvic bone marrow in gynecologic patients

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