Defining the effects of traffic-related air pollution on the human plasma proteome using an aptamer proteomic array: A dose-dependent increase in atherosclerosis-related proteins

Methylomic, proteomic, and metabolomic correlates of traffic-related air pollution: A systematic review, pathway analysis, and network analysis relating traffic-related air pollution to subclinical and clinical cardiorespiratory outcomes

“…Although we recommend the use of the most comprehensive technology available, the contribution of groundbreaking studies using older arrays to the current body of knowledge should not be understated [160,161]. Similarly, for the bioinformatics analyses of the methylomics results, researchers took advantage of the rapidly evolving tools such as KEGG for pathway analysis [39,43,114,133,157,158], the National Institutes of Health Databases for Annotation, Visualization and Integrated Discovery (NIH-DAVID) [39,53,62,152,153], Ingenuity Pathway Analysis (IPA) [40,63,126,148,154,162], Mummichog [15,92–94,101–103,105,106,163,164], and MetaboAnalyst [95–97,112,130,165–168].…”

“…Additionally, long-term PM 2.5 exposure was associated with hypomethylation of tumor necrosis factor ( TNF ) and TNF receptor superfamily member 13C ( TNFRSF13C ) [45,141]. Consistent with some but not all of the methylation trends, proteomics studies found that both short- and long-term exposure to TRAP was associated with higher levels of most cytokine and chemokine proteins (exceptions included inverse associations with tumor necrosis factor receptor superfamily member 11B, interleukin 4, interleukin 8, and eotaxin-1) [73,79,81,86,88,90,90,91,113,115,120,124,132,141,162,205–209]. These observations were consistent across pollutants and exposure windows.…”

“…Three of the methylomic markers (for genes CSF2, IL6, and IL10 ) were described in the section on inflammation and immunity. Briefly, short- and long-term TRAP was associated with hypomethylation of these markers and higher levels of the proteins they encode [58,73,88–91,113,115,124,141,162,205,225,235,254,255]. Hypermethylation of one methylomic marker relevant here (related to a gene that encodes interferon gamma ( IFNG )) was associated with short-term TRAP exposure (though short-term BC was associated with hypomethylation) [38,256].…”

ERS International Congress 2022: highlights from the Basic and Translational Science Assembly

“…DE-exposure dose-dependently increased plasma concentrations of 115 proteins, including fractalkine, apolipoprotein-B and matrix metalloprotease-12 (MMP-12), alongside macrophage inflammatory protein-3 (MIP-3) and apolipoprotein-M, all associated with cardiovascular disease [28].…”

“…Diesel exhaust exposure dose-dependently increased plasma concentrations of 115 proteins, including fractalkine, apolipoprotein-B and matrix metalloprotease-12, alongside macrophage inflammatory protein-3 and apolipoprotein-M, all associated with cardiovascular disease [ 28 ]. Current work focuses on examining these responses in a sex-disaggregated manner, to understand how responses to diesel exhaust exposure differ between males and females.…”