Defining the Epidemiology of Covid-19 — Studies Needed

Lipsitch, Marc; Swerdlow, David L.; Finelli, Lyn

doi:10.1056/nejmp2002125

Cited by 1,194 publications

(1,056 citation statements)

References 4 publications

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“…Recently, in this context of the COVID-19 outbreak, several questions have been raised, including what is the full spectrum of disease severity (which can range from asymptomatic, to symptomatic-but-mild, to severe, to requiring hospitalization, to fatal)? [47]. In this systematic review and random-effects meta-analysis, we tried to initially summarize clinical data on COVID-19 confirmed cases that were published during the first weeks of the outbreak.…”

Section: Discussionmentioning

confidence: 99%

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Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis

Rodríguez‐Morales

Cardona-Ospina

Gutiérrez‐Ocampo

et al. 2020

Travel Medicine and Infectious Disease

2,101

124

1,591

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Methods:We performed a systematic literature review with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases. Observational studies and also case reports, were included, and analyzed separately. We performed a random-effects model meta-analysis to calculate the pooled prevalence and 95% confidence interval (95%CI).Results: 660 articles were retrieved for the time frame (1/1/2020-2/23/2020). After screening, 27 articles were selected for full-text assessment, 19 being finally included for qualitative and quantitative analyses. Additionally, 39 case report articles were included and analyzed separately. For 656 patients, fever (88.7%, 95%CI 84.5-92.9%), cough (57.6%, 40.8-74.4%) and dyspnea (45.6%, 10.9-80.4%) were the most prevalent manifestations. Among the patients, 20.3% (95%CI 10.0-30.6%) required intensive care unit (ICU), 32.8% presented with acute respiratory distress syndrome (ARDS) (95%CI 13.7-51.8), 6.2% (95%CI 3.1-9.3) with shock. Some 13.9% (95%CI 6.2-21.5%) of hospitalized patients had fatal outcomes (case fatality rate, CFR).Conclusion: COVID-19 brings a huge burden to healthcare facilities, especially in patients with comorbidities. ICU was required for approximately 20% of polymorbid, COVID-19 infected patients and hospitalization was associated with a CFR of over 13%. As this virus spreads globally, countries need to urgently prepare human resources, infrastructure and facilities to treat severe COVID-19.

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Section: Discussionmentioning

confidence: 99%

“…This will allow for the identification of groups most likely to have poor outcomes so that we can focus on prevention and treatment efforts? [47].…”

Section: Discussionmentioning

confidence: 99%

Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis

Rodríguez‐Morales

Cardona-Ospina

Gutiérrez‐Ocampo

et al. 2020

Travel Medicine and Infectious Disease

2,101

124

1,591

View full text Add to dashboard Cite

show abstract

“…The imported patients with COVID-19 were those who visited or originated from Wuhan city, and were detected at the end of January 2020; subsequently, secondary and tertiary transmissions occurred nationwide 5 . Person-to-person transmission of SARS-CoV-2 in the hospital and family settings was confirmed in other geographical regions 6 .…”

mentioning

confidence: 99%

Clinical features and dynamics of viral load in imported and non-imported patients with COVID-19

Chen²,

Zhu

et al. 2020

International Journal of Infectious Diseases

188

162

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The manuscript contains 2 tables and 1 figure.J o u r n a l P r e -p r o o f Highlights 1. Characteristics of COVID-19 in imported and non-imported patients were analyzed.2. Fever was the most common symptom at the onset of illness.3. Half of patients had a low-grade temperature with a duration of fever <7 days.4. Viral load was undetectable for all patients on day 14 in the tertiary group.5. Virus was detectable on day 14 for 1/3rd of the imported and secondary patients. J o u r n a l P r e -p r o o f Abstract Objectives: To compare the clinical characteristics and the dynamics of viral load between the imported and non-imported patients with COVID-19. Design and methods: Data from 51 laboratory-confirmed patients were retrospectively analyzed.

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“…Rapid detection tools of common respiratory virus and bacteria, such as FilmArray TM Panel used here, help clinicians to determine causative pathogens of pneumonia in patients who are suspected with COVID-19 but have negative rRT-PCR result for SARS-CoV-2. One of the huge challenges for preventing and controlling of this pandemic-prone disease13,14 is the transmission of SARS-CoV-2 from COVID-19 patients who were asymptomatic or presented flu-like symptoms 15,16. Under this circumstances, quarantine and active surveillance of suspected patients and the application of rapid detection tools for etiology confirmation is strongly recommended.The confirmed COVID-19 cases in Taiwan belonged to two groups: international migration and locally transmitted.…”

mentioning

confidence: 99%

Featuring COVID-19 cases via screening symptomatic patients with epidemiologic link during flu season in a medical center of central Taiwan

Hsih

Cheng

et al. 2020

Journal of Microbiology, Immunology and Infection

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Background. Coronavirus disease 2019 , caused by severe acute respiratory syndrome coronavirus 2 (SARS-CO-V-2), was first reported in Wuhan, Hubei province, China has now rapidly spread over 50 countries. For the prevention and control of infection, Taiwan Centers for Disease Control initiated testing of SARS-CoV-2 on January 24 th 2020 for persons suspected with this disease. Until February 28 th , 43 flu-like symptomatic patients were screened in China Medical University Hospital. Methods. Two patients were confirmed positive for SARS-CoV-2 infection by rRT-PCR as COVID-19 patients A and B. Causative pathogens for included patients were detected using FilmArray TM Respiratory Panel. We retrospectively analyzed the clinical presentations, laboratory data, radiologic findings, and travel and exposure contact histories, of the COVID-19 patients in comparison to those with other respiratory infections. Results. Through contact with Taiwan No. 19 case patient on 27 th January, COVID-19 patients A and B were infected. Both patients had no identified comorbidities and developed mild illness with temporal fever, persistent cough, and lung interstitial infiltrates. Owing to the persistence of positive SARS-CoV-2 in respiratory specimen, the two COVID-19 patients are still in the isolation rooms despite recovery until 10 th of March. The results of FilmArray TM Respiratory Panel revealed 22 of the 41 non-COVID-19 patients were infected by particular pathogens.In general, seasonal respiratory pathogens are more prevalent than SARS-CoV-2 in symptomatic patients in non-COVID-19 endemic area during the flu season. Since all patients shared similar clinical and laboratory findings, expanded surveillance of detailed exposure history for suspected patients and application of rapid detection tools are highly recommended.

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Defining the Epidemiology of Covid-19 — Studies Needed

Cited by 1,194 publications

References 4 publications

Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis

Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis

Clinical features and dynamics of viral load in imported and non-imported patients with COVID-19

Featuring COVID-19 cases via screening symptomatic patients with epidemiologic link during flu season in a medical center of central Taiwan

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