2018
DOI: 10.1016/j.chest.2017.10.009
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Defining the “Frequent Exacerbator” Phenotype in COPD

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Cited by 71 publications
(65 citation statements)
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“…A recent study of chronic obstructive pulmonary disease patients adopted a similar approach to define 'frequent exacerbator' phenotype. 18 We found that ≥2 HF admissions per year was the best threshold that defined 'frequent admitter' phenotype. It was associated with increased mortality compared to patients who accrued ≤1 HF admission per year.…”
Section: Discussionmentioning
confidence: 78%
See 1 more Smart Citation
“…A recent study of chronic obstructive pulmonary disease patients adopted a similar approach to define 'frequent exacerbator' phenotype. 18 We found that ≥2 HF admissions per year was the best threshold that defined 'frequent admitter' phenotype. It was associated with increased mortality compared to patients who accrued ≤1 HF admission per year.…”
Section: Discussionmentioning
confidence: 78%
“…Indeed, machine learning methods, specifically KmL, has been used in other fields to define disease phenotype. A recent study of chronic obstructive pulmonary disease patients adopted a similar approach to define ‘frequent exacerbator’ phenotype …”
Section: Discussionmentioning
confidence: 99%
“…Frequent exacerbators are a group of subjects with 2 or more exacerbations per year. 70 , 82 Although recent data suggest that the frequent exacerbator phenotype is quite infrequent in a large cohort study, this phenotype seems to be quite stable over time because the best predictor for exacerbations is past history of exacerbations. 83 Other circulating biomarkers have been examined as part of the SPIROMICS and COPDGene cohorts to characterize this phenotype, and except for high levels of decorin and α 2 -macroglobulin, none have proved to be robust enough to be replicated across cohorts.…”
Section: Recognizing Subpopulations Within Copd: “Taxonomy” Of Airwaymentioning
confidence: 99%
“…This was further explored in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) cohort, demonstrating that severity and frequency of exacerbations correlated with the severity of COPD and that across all GOLD stages, the single best predictor of exacerbations was a history of exacerbations [ 15 ]. Similarly, study of an unbiased prospective cohort COPD patients independently suggested that a history of two moderate or severe exacerbations was the best predictor of subsequent events [ 16 ]. However, a recent large observational cohort suggested that individuals meeting this threshold are rare and that variability in exacerbation rate over time is significant [ 3 ].…”
Section: Introductionmentioning
confidence: 99%