Defining the left ventricular base in mitral valve prolapse: impact on systolic function and regurgitation

Wolff, Ryan; Uretsky, Seth

doi:10.1007/s10554-020-01927-0

Cited by 10 publications

(6 citation statements)

References 14 publications

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“…The prolapse volume represents an additional LV volume load beyond that of the regurgitation, which results in an overestimated EF and could lead to discordant LV and LA size. 21,24 Among patients with bileaflet MVP (BMVP), increase of both MR and prolapse volume was associated with proportionate increases in LV diastolic volume. 21 LV dysfunction is present in a number of MVP patients.…”

Section: Mitral Cleftmentioning

confidence: 99%

Mitral Valve Prolapse—The Role of Cardiac Imaging Modalities

2022

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Section: Mitral Cleftmentioning

confidence: 99%

Mitral Valve Prolapse—The Role of Cardiac Imaging Modalities

2022

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“…method (at the mitral valve leaflets). Better correlations between the LVEDvol and MRvol (r = 0.79 and r = 0.67, respectively) and the LVEF and global myocardial strain (r = 0.86, r = 0.68 respectively) have been shown using the functional the anatomical method (20). However, in a recent study, the MRvol determined by CMR or echocardiography correlated with the LVEDvol (r = 0.68 and r = 0.66, respectively) unlike for the RF (54).…”

Section: Figurementioning

confidence: 98%

“…In patients with bileaflet MVP, positioning of the basal slice in CMR at the mitral annulus (also called the "functional method") (20) means that the blood trapped between the annulus and leaflets is not included in the LVESvol estimation, leading to a higher LVSV, MRvol, and EF than that estimated using the "anatomical"…”

Section: Cine Imaging and Cine Phase Contrast Velocity Mappingmentioning

confidence: 99%

The evolving role of cardiovascular magnetic resonance in the assessment of mitral valve prolapse

Vermès

Altes

Iacuzio

et al. 2023

Front. Cardiovasc. Med.

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Mitral valve prolapse (MVP), characterized by a displacement > 2 mm above the mitral annulus of one or both bileaflets, with or without leaflet thickening, is a common valvular heart disease, with a prevalence of approximately 2% in western countries. Although this population has a generally good overall prognosis, MVP can be associated with mitral regurgitation (MR), left ventricular (LV) remodeling leading to heart failure, ventricular arrhythmia, and, the most devastating complication, sudden cardiac death, especially in myxomatous bileaflet prolapse (Barlow's disease). Among several prognostic factors reported in the literature, LV fibrosis and mitral annular disjunction may act as an arrhythmogenic substrate in this population. Cardiac magnetic resonance (CMR) has emerged as a reliable tool for assessing MVP, MR severity, LV remodeling, and fibrosis. Indeed, CMR is the gold standard imaging modality to assess ventricular volume, function, and wall motion abnormalities; it allows accurate calculation of the regurgitant volume and regurgitant fraction in MR using a combination of LV volumetric measurement and aortic flow quantification, independent of regurgitant jet morphology and valid in cases of multiple valvulopathies. Moreover, CMR is a unique imaging modality that can assess non-invasively focal and diffuse fibrosis using late gadolinium enhancement sequences and, more recently, T1 mapping. This review describes the use of CMR in patients with MVP and its role in identifying patients at high risk of ventricular arrhythmia.

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“…34 However, this remains hypothesis generating and further evidence is required to elucidate the interplay among MAD, prolapse volume, and mitral RVol quantification. Accordingly, Wolff and Uretsky 35 showed that in patients with bileaflet prolapse the base of the LV by CMR at end systole should be at the level of the mitral annulus so that mitral RVol most accurately reflects the functional significance of the mitral valve disease and LVEF most accurately reflects global systolic LV function.…”

Section: Comparison Between Mitral Rvol Assessed By the Pisa Versus C...mentioning

confidence: 99%

Comparison of Mitral Regurgitant Volume Assessment between Proximal Flow Convergence and Volumetric Methods in Patients with Significant Primary Mitral Regurgitation: An Echocardiographic and Cardiac Magnetic Resonance Imaging Study

Altes

Lévy

Iacuzio

et al. 2022

Journal of the American Society of Echocardiography

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Defining the left ventricular base in mitral valve prolapse: impact on systolic function and regurgitation

Cited by 10 publications

References 14 publications

Mitral Valve Prolapse—The Role of Cardiac Imaging Modalities

Mitral Valve Prolapse—The Role of Cardiac Imaging Modalities

The evolving role of cardiovascular magnetic resonance in the assessment of mitral valve prolapse

Comparison of Mitral Regurgitant Volume Assessment between Proximal Flow Convergence and Volumetric Methods in Patients with Significant Primary Mitral Regurgitation: An Echocardiographic and Cardiac Magnetic Resonance Imaging Study

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