2022
DOI: 10.21203/rs.3.rs-2235573/v1
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Defining the Penumbra in a Preclinical Model of Subarachnoid Hemorrhage

Abstract: Subarachnoid hemorrhage (SAH) is a form of stroke that most often results from a ruptured cerebral aneurysm that spills blood into the surrounding tissue. In contrast with the well-established and predictable ischemic penumbra regions in ischemic stroke, this crucial therapeutic target has not yet been well-described in SAH. Considering that SAH may cause micro-infarcts and delayed cerebral ischemia far from the aneurysm rupture, and that these disruptions are closely linked to behavioral impairments, it is im… Show more

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Cited by 1 publication
(3 citation statements)
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“…The novel object recognition test (NOR) assesses the working recognition memory of rats based on the assumption that a healthy rat will interact more with a novel object rather than one to which they are acclimated [40]. The experiment was conducted in a 60x60x30 cm open field, comprised of opaque black acrylic.…”
Section: Novel Object Recognition Testmentioning
confidence: 99%
See 2 more Smart Citations
“…The novel object recognition test (NOR) assesses the working recognition memory of rats based on the assumption that a healthy rat will interact more with a novel object rather than one to which they are acclimated [40]. The experiment was conducted in a 60x60x30 cm open field, comprised of opaque black acrylic.…”
Section: Novel Object Recognition Testmentioning
confidence: 99%
“…The Y-maze test assesses long-term spatial memory [40]. The maze is comprised of a Y-shaped structure (MazeEngineers, USA), with three blue, opaque plastic arms that are positioned 120 degrees apart from each other.…”
Section: Y-maze Testmentioning
confidence: 99%
See 1 more Smart Citation