Defining the relationship between BP and target organ damage: the hot target-organ substudy

Haley, William E.; Harris, T.M.; TUCKER, CLARA; Zachariah, Prince K.

doi:10.1016/s0895-7061(99)80274-x

Cited by 1 publication

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“…Diabetic subjects had progressively greater benefits with lower pressures, with reduction of cardiovascular events by more than 60% [39]. Few renal data are available, although preliminary reports of a target-organ substudy indicate regression of microalbuminuria occurred in proportion to achieved arterial pressures [40].…”

Section: Treatment Of Hypertension As a Modifier Of Renal Disease Promentioning

confidence: 99%

Importance of blood pressure reduction for prevention of progression of renal disease

Textor

Canzanello

1999

Current Science Inc

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Despite reduction of stroke and coronary mortality rates, progression of renal disease to end stage continues to occur with increasing frequency. Recent studies emphasize common pathways of elevated arterial pressures that produce increased glomerular capillary pressures and increase filtered proteins in the urinary space. Such proteinuria, along with activation of the intrarenal renin-angiotensin system, endothelin, and inflammatory cytokines, magnifies progressive renal injury and fibrosis. Malignant forms of hypertension with severe arteriolar injury and proteinuria can be treated effectively with current antihypertensive regimens with improved patient survival. Several recent studies indicate improved renal outcomes in proteinuric diseases, generally regardless of the specific antihypertensive agent. Recent trials of hypertensive subjects with minimal proteinuria demonstrate slower rates of disease progression than that seen in subjects with proteinuria above 1 gram per day. Reduction of arterial pressures, particularly when it leads to reduced proteinuria, can slow the progression of many renal diseases.

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Section: Treatment Of Hypertension As a Modifier Of Renal Disease Promentioning

confidence: 99%

Importance of blood pressure reduction for prevention of progression of renal disease

Textor

Canzanello

1999

Current Science Inc

View full text Add to dashboard Cite

show abstract

Defining the relationship between BP and target organ damage: the hot target-organ substudy

Cited by 1 publication

References 0 publications

Importance of blood pressure reduction for prevention of progression of renal disease

Importance of blood pressure reduction for prevention of progression of renal disease

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