Defining the role of radiofrequency ablation and stereotactic ablative radiotherapy in patients with high‐risk, early‐stage non‐small cell lung cancer

Louie, Alexander V.; Senan, Suresh

doi:10.1002/cncr.29698

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…(2, 3) A recent prospective trial of thermal ablation in medically inoperable early stage non small cell lung cancer demonstrated comparable overall survival rates to stereotactic body radiotherapy (SBRT) and surgery (4), though high rates of local recurrence (7–55%) remain a major critique. (5, 6) Evaluation of determinants of ablation success have to date largely focused on technique-associated parameters, such as tumor size and treatment margin size. (7) An association between presence of Ki67+ tumor cells and local tumor progression after ablation of lung tumors has been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Micropapillary and/or Solid Histologic Subtype Based on Pre-Treatment Biopsy Predicts Local Recurrence After Thermal Ablation of Lung Adenocarcinoma

Gao

Stein

Petre

et al. 2017

Cardiovasc Intervent Radiol

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Section: Introductionmentioning

confidence: 99%

Micropapillary and/or Solid Histologic Subtype Based on Pre-Treatment Biopsy Predicts Local Recurrence After Thermal Ablation of Lung Adenocarcinoma

Gao

Stein

Petre

et al. 2017

Cardiovasc Intervent Radiol

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“…[7–10] RF ablation has a very low rate of complications, and is generally well tolerated. It involves passing an alternating electrical current through the target tissues, thereby inducing agitation of ions and resistive heating in those tissues.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of radiofrequency ablation as an alternative to surgical intervention in patients with huge multiloculated pyogenic liver abscesses

Shi

Ding²,

Gao³

et al. 2016

Medicine

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This retrospective cohort study investigated the feasibility of radiofrequency (RF) ablation as an alternative to surgical intervention in patients with huge multiloculated pyogenic liver abscesses (PLAs).From August 2010 to April 2016, 83 patients with PLA were admitted to Beijing Chao-Yang Hospital, China. Four of these patients had huge multiloculated PLAs and underwent RF ablation plus antibiotics. The inclusion criteria for RF ablation were as follows: multiloculated PLA confirmed by computed tomography (CT) or magnetic resonance imaging (MRI), widest diameter of the PLA ≥5 cm, failure to respond to or not suitable to treatment with percutaneous drainage (PD), and patient refusal of surgery. The safety and effectiveness of RF ablation were initially assessed. All patients were commenced on antibiotics on admission to our hospital. CT-guided percutaneous catheter drainage was attempted in one patient but was unsuccessful. The main organism isolated from cultures of these patients’ blood or abscess samples was Klebsiella pneumoniae (3/4). RF ablation was performed as soon as eligibility according to the above criteria was established.RF ablation was technically successful in all 4 study patients, all PLAs being completely eradicated. The median duration of fever after RF ablation was 4.5 days. No abscesses recurred; thus, this strategy for managing PLA was 100% successful (4/4). No procedure-related deaths or major complications occurred. One patient had an asymptomatic right pleural effusion that resolved with conservative treatment including albumin infusion and diuretics.Our preliminary data indicate that RF ablation is a safe, feasible, and effective treatment for huge multiloculated PLAs. It should be considered as an alternative treatment for patients who fail to respond to or not suitable for PD plus antibiotics and refuse surgical intervention.

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Defining the role of radiofrequency ablation and stereotactic ablative radiotherapy in patients with high‐risk, early‐stage non‐small cell lung cancer

Cited by 2 publications

References 9 publications

Micropapillary and/or Solid Histologic Subtype Based on Pre-Treatment Biopsy Predicts Local Recurrence After Thermal Ablation of Lung Adenocarcinoma

Micropapillary and/or Solid Histologic Subtype Based on Pre-Treatment Biopsy Predicts Local Recurrence After Thermal Ablation of Lung Adenocarcinoma

Feasibility of radiofrequency ablation as an alternative to surgical intervention in patients with huge multiloculated pyogenic liver abscesses

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