Definition and semantics: “Peritoneal Carcinomatosis” should be abandoned and replaced by “Peritoneal Metastasis”

Reymond, Marc A.

doi:10.1515/pp-2017-0020

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…Peritoneal metastasis is the primary presentation of advanced-stage ovarian cancer and is defined as a trans-peritoneal invasion of the serosal linings of the peritoneal cavity by metastatic malignant cells from the primary tumor through a cascade of biological events [ 54 ]. Patients with peritoneal metastasis had a relatively abysmal prognosis compared to patients without carcinomatosis [ 55 ].…”

Section: Augmented Fatty Acid Metabolism (Fam) Is Conducive To the Me...mentioning

confidence: 99%

New Insights into Ferroptosis Initiating Therapies (FIT) by Targeting the Rewired Lipid Metabolism in Ovarian Cancer Peritoneal Metastases

Zhan

Yung

Siu

et al. 2022

IJMS

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Ovarian cancer is one of the most lethal gynecological cancers worldwide. The poor prognosis of this malignancy is substantially attributed to the inadequate symptomatic biomarkers for early diagnosis and effective remedies to cure the disease against chemoresistance and metastasis. Ovarian cancer metastasis is often relatively passive, and the single clusters of ovarian cancer cells detached from the primary ovarian tumor are transcoelomic spread by the peritoneal fluid throughout the peritoneum cavity and omentum. Our earlier studies revealed that lipid-enriched ascitic/omental microenvironment enforced metastatic ovarian cancer cells to undertake metabolic reprogramming and utilize free fatty acids as the main energy source for tumor progression and aggression. Intriguingly, cell susceptibility to ferroptosis has been tightly correlated with the dysregulated fatty acid metabolism (FAM), and enhanced iron uptake as the prominent features of ferroptosis are attributed to the strengthened lipid peroxidation and aberrant iron accumulation, suggesting that ferroptosis induction is a targetable vulnerability to prevent cancer metastasis. Therefore, the standpoints about tackling altered FAM in combination with ferroptosis initiation as a dual-targeted therapy against advanced ovarian cancer were highlighted herein. Furthermore, a discussion on the prospect and challenge of inducing ferroptosis as an innovative therapeutic approach for reversing remedial resistance in cancer interventions was included. It is hoped this proof-of-concept review will indicate appropriate directions for speeding up the translational application of ferroptosis-inducing compounds (FINs) to improve the efficacy of ovarian cancer treatment.

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Section: Augmented Fatty Acid Metabolism (Fam) Is Conducive To the Me...mentioning

confidence: 99%

New Insights into Ferroptosis Initiating Therapies (FIT) by Targeting the Rewired Lipid Metabolism in Ovarian Cancer Peritoneal Metastases

Zhan

Yung

Siu

et al. 2022

IJMS

View full text Add to dashboard Cite

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Medical devices for treating peritoneal metastasis in low-income countries: is less more?

Pocard

2017

Pleura and Peritoneum

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Definition and semantics: “Peritoneal Carcinomatosis” should be abandoned and replaced by “Peritoneal Metastasis”

Cited by 2 publications

References 13 publications

New Insights into Ferroptosis Initiating Therapies (FIT) by Targeting the Rewired Lipid Metabolism in Ovarian Cancer Peritoneal Metastases

New Insights into Ferroptosis Initiating Therapies (FIT) by Targeting the Rewired Lipid Metabolism in Ovarian Cancer Peritoneal Metastases

Medical devices for treating peritoneal metastasis in low-income countries: is less more?

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