Oral appliance therapy (OAT) has been used to manage sleep-related breathing disorders (SRBDs), such as obstructive sleep apnea (OSA) and snoring, for more than 20 years. However, dental sleep medicine standards of clinical practice have not been clearly defined. SRBD prevalence rates have grown to double digits, presenting an increased need for dentists proficient in dental sleep medicine. A standardized approach to patient management, which underscores the collaborative nature necessary between dentists and physicians, is needed. These standards provide guidance for patient examination, patient screening, education, and treatment management including follow-up care. Although this paper introduces best practices for the practice of dental sleep medicine as it currently exists, the reader should recognize the fluid and dynamic nature of dental sleep medicine and understand that periodic updates to these standards will be required.