Definition of the limit of quantification in the presence of instrumental and non-instrumental errors. Comparison among various definitions applied to the calibration of zinc by inductively coupled plasma–mass spectrometry

Badocco, Denis; Lavagnini, Irma; Mondin, Andrea; Favaro, Gabriella; Pastore, Paolo

doi:10.1016/j.sab.2015.10.004

Cited by 14 publications

(14 citation statements)

References 17 publications

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“…Agilent Technologies International Japan, Ltd., Tokyo, Japan). The operating conditions and data acquisition parameters were the same as reported ( Badocco et al, 2015 ). The multi-element calibration standard used for all calibrations was the IV-ICPMS-71A (Inorganic-Ventures, 100 ml) containing 10 mg/L of Ag, Al, As, B, Ba, Be, Ca, Cd, Ce, Co, Cr, Cs, Cu, Dy, Er, Eu, Fe, Ga, Gd, Ho, K, La, Lu, Mg, Mn, Na, Nd, Ni, P, Pb, Pr, Rb, S, Se, Sm, Sr, Th, Tl, Tm, U, V, Yb and Zn.…”

Section: Methodsmentioning

confidence: 99%

Mitochondrial Cytochrome c Oxidase Defects Alter Cellular Homeostasis of Transition Metals

Brischigliaro

Badocco

Costa

et al. 2022

Front. Cell Dev. Biol.

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The redox activity of cytochrome c oxidase (COX), the terminal oxidase of the mitochondrial respiratory chain (MRC), depends on the incorporation of iron and copper into its catalytic centers. Many mitochondrial proteins have specific roles for the synthesis and delivery of metal-containing cofactors during COX biogenesis. In addition, a large set of different factors possess other molecular functions as chaperones or translocators that are also necessary for the correct maturation of these complexes. Pathological variants in genes encoding structural MRC subunits and these different assembly factors produce respiratory chain deficiency and lead to mitochondrial disease. COX deficiency in Drosophila melanogaster, induced by downregulated expression of three different assembly factors and one structural subunit, resulted in decreased copper content in the mitochondria accompanied by different degrees of increase in the cytosol. The disturbances in metal homeostasis were not limited only to copper, as some changes in the levels of cytosolic and/or mitochondrial iron, manganase and, especially, zinc were observed in several of the COX-deficient groups. The altered copper and zinc handling in the COX defective models resulted in a transcriptional response decreasing the expression of copper transporters and increasing the expression of metallothioneins. We conclude that COX deficiency is generally responsible for an altered mitochondrial and cellular homeostasis of transition metals, with variations depending on the origin of COX assembly defect.

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Section: Methodsmentioning

confidence: 99%

Mitochondrial Cytochrome c Oxidase Defects Alter Cellular Homeostasis of Transition Metals

Brischigliaro

Badocco

Costa

et al. 2022

Front. Cell Dev. Biol.

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“…ICP‐MS analysis for the determination of the B and Fe content was carried out with an Agilent Technologies 7700x ICP‐MS (Agilent Technologies International Japan, Ltd., Tokyo, Japan) at operating conditions and data acquisition parameters as previously described. [ 80 ] The instrument was equipped with an octupole collision cell operating in kinetic energy discrimination mode used for the removal of polyatomic interferences and argon‐based interferences. Optimal performance was attained by using the collision cell in He mode.…”

Section: Methodsmentioning

confidence: 99%

Biocompatible Iron–Boron Nanoparticles Designed for Neutron Capture Therapy Guided by Magnetic Resonance Imaging

Torresan

Guadagnini

Badocco

et al. 2020

Adv Healthcare Materials

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The combination of multiple functions in a single nanoparticle (NP) represents a key advantage of nanomedicine compared to traditional medical approaches. This is well represented by radiotherapy in which the dose of ionizing radiation should be calibrated on sensitizers biodistribution. Ideally, this is possible when the drug acts both as radiation enhancer and imaging contrast agent. Here, an easy, one‐step, laser‐assisted synthetic procedure is used to generate iron–boron (Fe–B) NPs featuring the set of functions required to assist neutron capture therapy (NCT) with magnetic resonance imaging. The Fe–B NPs exceed by three orders of magnitude the payload of boron isotopes contained in clinical sensitizers. The Fe–B NPs have magnetic properties of interest also for magnetophoretic accumulation in tissues and magnetic hyperthermia to assist drug permeation in tissues. Besides, Fe–B NPs are biocompatible and undergo slow degradation in the lysosomal environment that facilitates in vivo clearance through the liver–spleen–kidneys pathway. Overall, the Fe–B NPs represent a new promising tool for future exploitation in magnetic resonance imaging‐guided boron NCT at higher levels of efficacy and tolerability.

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“…The operating conditions and data acquisition parameters were chosen according to a previous work. 48 The internal standard mixture (Agilent, 5183-4681) containing Bi, Ge, In, Sc, Tb, Y and Li at 10 mg mL À1 each in 5% HNO 3 was used. The internal standard was added to the sample solution via a suitable T-junction.…”

Section: Icp-msmentioning

confidence: 99%

Impact of inversion and non-stoichiometry on the transport properties of mixed zinc-cobalt ferrites

et al. 2022

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Definition of the limit of quantification in the presence of instrumental and non-instrumental errors. Comparison among various definitions applied to the calibration of zinc by inductively coupled plasma–mass spectrometry

Cited by 14 publications

References 17 publications

Mitochondrial Cytochrome c Oxidase Defects Alter Cellular Homeostasis of Transition Metals

Mitochondrial Cytochrome c Oxidase Defects Alter Cellular Homeostasis of Transition Metals

Biocompatible Iron–Boron Nanoparticles Designed for Neutron Capture Therapy Guided by Magnetic Resonance Imaging

Impact of inversion and non-stoichiometry on the transport properties of mixed zinc-cobalt ferrites

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