Definitive GRID and Fractionated Radiation in Bulky Head and Neck Cancer Associated With Low Rates of Distant Metastasis

Edwards, James; Shah, Pratik; Huhn, J.L.; Clair, William St; Regine, William F.; Mohiuddin, M.; Kudrimoti, Mahesh

doi:10.1016/j.ijrobp.2015.07.1399

Cited by 13 publications

(12 citation statements)

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“…It assessed demographic characteristics, past medical history, current condition, diagnostic assessment, treatment procedure, post-intervention condition, adverse events, and lessons to learn. The total score was categorized as low (0–3) and high quality (4–8) [ 6 ].…”

Section: Methodsmentioning

confidence: 99%

The outcome of radiation therapy as a primary treatment in orbital lymphoma: a systematic review

Oktariana

Andriana

Nugroho

2022

Rep Pract Oncol Radiother.

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Section: Methodsmentioning

confidence: 99%

The outcome of radiation therapy as a primary treatment in orbital lymphoma: a systematic review

Oktariana

Andriana

Nugroho

2022

Rep Pract Oncol Radiother.

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“…Pathological analysis showed a CR of 85% and 15% PR. The local tumour control of 91% at three years was observed in a cohort of 53 patients with H&N cancer T4 and N3, treated with a single fraction 15 Gy GRID followed with conventional RT in a curative setting [ 81 ]. Normal tissue toxicities remained mild for most of the patients with 4% developing more than Grade 3 complications.…”

Section: Preclinical and Clinical Evidence With Spatially Fractionate...mentioning

confidence: 99%

Radiobiological and Treatment-Related Aspects of Spatially Fractionated Radiotherapy

Moghaddasi

Reid²,

Bezak

et al. 2022

IJMS

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The continuously evolving field of radiotherapy aims to devise and implement techniques that allow for greater tumour control and better sparing of critical organs. Investigations into the complexity of tumour radiobiology confirmed the high heterogeneity of tumours as being responsible for the often poor treatment outcome. Hypoxic subvolumes, a subpopulation of cancer stem cells, as well as the inherent or acquired radioresistance define tumour aggressiveness and metastatic potential, which remain a therapeutic challenge. Non-conventional irradiation techniques, such as spatially fractionated radiotherapy, have been developed to tackle some of these challenges and to offer a high therapeutic index when treating radioresistant tumours. The goal of this article was to highlight the current knowledge on the molecular and radiobiological mechanisms behind spatially fractionated radiotherapy and to present the up-to-date preclinical and clinical evidence towards the therapeutic potential of this technique involving both photon and proton beams.

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“…1 case of carotid blow-in after neck dissection. may have not been attributable to GRID therapy.Neuner et al [59]79Bulky tumor sMixedMixed10–20 Gy9–70.2 GyPain 74–75%Mass effect 67–73%12 pts had G3- G4 toxicities.Edwards et al [60]53Locally advancedHead and NeckHead and Neck15 Gy48–79.2 Gy81% LC, 9% DM4% G3+ toxicities…”

Section: Grid’s Application In Megavoltage Eramentioning

confidence: 99%

Spatially fractionated radiation therapy: History, present and the future

Yan

Khan

Wu³

et al. 2020

Clinical and Translational Radiation Oncology

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Definitive GRID and Fractionated Radiation in Bulky Head and Neck Cancer Associated With Low Rates of Distant Metastasis

Cited by 13 publications

References 0 publications

The outcome of radiation therapy as a primary treatment in orbital lymphoma: a systematic review

The outcome of radiation therapy as a primary treatment in orbital lymphoma: a systematic review

Radiobiological and Treatment-Related Aspects of Spatially Fractionated Radiotherapy

Spatially fractionated radiation therapy: History, present and the future

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