Definitive Radiation for Stage I Lung Cancer in a Screened Population: Results From the I-ELCAP

Berlin, Eva; Buckstein, Michael; Yip, Rowena; Yankelevitz, David F.; Rosenzweig, Kenneth E.; Henschke, Claudia I.; Investigators, I-Elcap

doi:10.1016/j.ijrobp.2019.01.069

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…None of these, however, have had critical assessment, and often there is only limited data for small lung cancers. Published cohort studies using the I-ELCAP database (114,(135)(136)(137)(138) have already provided timely outcome results and Quality of Life measures which will become an increasingly important consideration in treatment determination given the high long-term cure rates of screen-diagnosed lung cancer (139)(140)(141)(142)(143).…”

Section: New Paradigms Of Treatment For Early Lung Cancersmentioning

confidence: 99%

Review of the future of lung cancer screening

Yip¹,

Jirapatnakul²,

Li³

et al. 2022

Curr Chall Thorac Surg

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Lung cancer screening has progressed greatly in the last two decades since the initial publication of ELCAP in 1999. Since then, large randomized trials, the NLST and NELSON studies, have also shown the benefit of lung cancer screening with CT, and it is now widely available. There are many areas for improving the benefit of screening by refining the eligibility criteria, continued optimization of the screening regimen, identifying other related diseases, and improved treatment. As artificial intelligence (AI) techniques continue to improve, an automated report of all diseases can be produced from the low-dose CT scan. New screening tests are being developed for lung cancer including blood-based tests. There is growing recognition that use of risk factor-based criteria which dichotomize age and pack-years of smoking to select eligible individuals for screening may not be the most efficient and may also lead to increased lung cancer disparity. Continued research will focus on optimal approaches for selecting high risk individuals for lung cancer screening and thus hopefully expand eligibility criteria beyond the current criteria which include only 20% of lung cancer patients. With the increase in early stage lung cancers identified from lung cancer screening, a key focus of ongoing research is the treatment of these cancers.

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Section: New Paradigms Of Treatment For Early Lung Cancersmentioning

confidence: 99%

Review of the future of lung cancer screening

Yip¹,

Jirapatnakul²,

Li³

et al. 2022

Curr Chall Thorac Surg

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although in some retrospective analysis of series of cases and reviews (1,9,10), the authors comment that the overall survival advantage for surgery could be related to patient selection bias-healthier cases are allocated to surgery-the fact is that in most published series (11)(12)(13)(14)(15) RT was restricted to patients medically inoperable or refusing surgery. The definition of "medical inoperability" is lacking in some publications and rarely (16,17), it is stated that patient's operability was evaluated in all cases by thoracic surgeons experienced in lung cancer surgery, as recommended (8).…”

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confidence: 99%