We investigate drop break-up morphology, occurrence, time and size distribution, through large ensembles of high-fidelity direct-numerical simulations of drops in homogeneous isotropic turbulence, spanning a wide range of parameters in terms of the Weber number
$We$
, viscosity ratio between the drop and the carrier flow
$\mu _r=\mu _d/\mu _l$
, where d is the drop diameter, and Reynolds (
$Re$
) number. For
$\mu _r \leq 20$
, we find a nearly constant critical
$We$
, while it increases with
$\mu _r$
(and
$Re$
) when
$\mu _r > 20$
, and the transition can be described in terms of a drop Reynolds number. The break-up time is delayed when
$\mu _r$
increases and is a function of distance to criticality. The first break-up child-size distributions for
$\mu _r \leq 20$
transition from M to U shape when the distance to criticality is increased. At high
$\mu _r$
, the shape of the distribution is modified. The first break-up child-size distribution gives only limited information on the fragmentation dynamics, as the subsequent break-up sequence is controlled by the drop geometry and viscosity. At high
$We$
, a
$d^{-3/2}$
size distribution is observed for
$\mu _r \leq 20$
, which can be explained by capillary-driven processes, while for
$\mu _r > 20$
, almost all drops formed by the fragmentation process are at the smallest scale, controlled by the diameter of the very extended filament, which exhibits a snake-like shape prior to break-up.