The heterogeneous plastic deformation characteristics of HPT processed Interstitial-free steels (IF-steels) and the effects of friction coefficient on heterogeneous plastic deformation characteristics were investigated through the effective strain distribution on the transversal plane of HTP disks. Using DEFORM-3D finite analysis software, the simulation results were obtained firstly, verified by experimental approaches. The deformation characteristic is remarkably heterogeneous in radial and axial direction on the transversal plane of HPT-processed IF steel samples. Along the radial direction, the low value of the effective strain exists in the central position, high value exists in the edge, correspondingly. Along the axial direction, the value of the bottom surface is significantly higher than other surfaces. In addition, friction coefficient plays a significantly role in early torsion stage. More and more heterogeneous plastic deformation characteristics are exhibited following the friction coefficient increase. The experimental results strongly support the simulation conclusions.