Deformation of cellular components of bone forming cells when exposed to a magnetic field

Iwasaka, Masakazu

doi:10.1063/1.5079635

“…It should be noted here that regardless of the above described swelling mechanism, magnetically induced swelling and shape changing of cells (with no paramagnetic agents) have been observed under the following conditions: (i) osteoblasts adhered to glass substrates in the presence of a 5 T magnetic field [ 64 ] and (ii) human THP-1 leukemia cells (volume increases up to 90%) after 24 h of exposure to a spatially modulated high-gradient magnetic field [ 65 ].…”

Section: Resultsmentioning

confidence: 99%

Effects of High Magnetic Fields on the Diffusion of Biologically Active Molecules

Zablotskii

¹

,

Polyakova

²

,

Dejneka

³

2021

Cells

View full text Add to dashboard Cite

The diffusion of biologically active molecules is a ubiquitous process, controlling many mechanisms and the characteristic time scales for pivotal processes in living cells. Here, we show how a high static magnetic field (MF) affects the diffusion of paramagnetic and diamagnetic species including oxygen, hemoglobin, and drugs. We derive and solve the equation describing diffusion of such biologically active molecules in the presence of an MF as well as reveal the underlying mechanism of the MF’s effect on diffusion. We found that a high MF accelerates diffusion of diamagnetic species while slowing the diffusion of paramagnetic molecules in cell cytoplasm. When applied to oxygen and hemoglobin diffusion in red blood cells, our results suggest that an MF may significantly alter the gas exchange in an erythrocyte and cause swelling. Our prediction that the diffusion rate and characteristic time can be controlled by an MF opens new avenues for experimental studies foreseeing numerous biomedical applications.

show abstract

“…It should be noted here that regardless of the above described swelling mechanism, magnetically induced swelling and shape changing of cells (with no paramagnetic agents) have been observed under the following conditions: i) osteoblasts adhered to glass substrates in the presence of a 5 T-magnetic field [62] and ii) human THP-1 leukemia cells (volume increase up to 90 %) after 24 hours of exposure to a spatially modulated high-gradient magnetic field [63].…”

Section: Resultsmentioning

confidence: 99%

Effects of High Magnetic Fields on Diffusion of Biologically Active Molecules

Zablotskii

¹

,

Polyakova

²

,

Dejneka

³

2020

Preprint

0

View full text Add to dashboard Cite

The diffusion of biologically active molecules is a ubiquitous process, controlling many mechanisms and the characteristic time scales for pivotal processes in living cells. Here, we show how a high static magnetic field (MF) affects the diffusion of paramagnetic and diamagnetic species, including oxygen, hemoglobin, ROS and drugs. We derive and solve the equation describing diffusion of such biologically active molecules in the presence of a MF as well as reveal the underlying mechanism of the MF effect on diffusion. We find that a high MF accelerates diffusion of diamagnetic species while slowing the diffusion of paramagnetic molecules in cell cytoplasm. When applied to oxygen and hemoglobin diffusion in red blood cells, our results suggest that a MF may significantly alter the gas exchange in an erythrocyte and cause swelling. Our prediction that the diffusion rate and characteristic time can be controlled by a MF opens new avenues for experimental studies foreseeing numerous biomedical applications.SignificanceWe show that diffusion processes of biologically active molecules (hemoglobin, oxygen, reactive oxygen species, etc.) and paramagnetic drugs can be remotely controlled by high static magnetic fields. Since diffusion processes determine the reference time scale for all other processes in living cells as well as the propagation speed of signaling molecules during cell-to-cell communication, our results – the magnetic field dependences of the diffusion rate and characteristic time – may serve as an important key for revealing and understanding the mechanisms of magnetic field action on living cells, tissue and organisms.

show abstract

“…In addition exposure to the magnetic field gradient caused redistribution of the organelles away from the nucleus and cell elongation (Bz 1.2 T at the distance of 5 and 10 cm). Iwasaka (2019) studied the structure of a bone-forming osteoblast cell line exposed to a 5 T SMF. He showed that there was a deformation of the cell shape with a reduction of cellular width and changed structures with a round appearance under the SMF.…”

Section: Cell Structurementioning

confidence: 99%

Static magnetic fields as a factor in modification of tissue and cell structure: a review

Saletnik,

Puchalska-Sarna,

Saletnik

et al. 2024

Int. Agrophys.

2

0

View full text Add to dashboard Cite

Deformation of cellular components of bone forming cells when exposed to a magnetic field

Abstract: Effects of a high DC magnetic field on spin reorientation in dysprosium-yttrium iron garnets at low temperatures AIP Advances 9, 035326 (2019);

Cited by 3 publications

References 10 publications

Effects of High Magnetic Fields on the Diffusion of Biologically Active Molecules

Effects of High Magnetic Fields on the Diffusion of Biologically Active Molecules

Effects of High Magnetic Fields on Diffusion of Biologically Active Molecules

Static magnetic fields as a factor in modification of tissue and cell structure: a review

Contact Info

Product

Resources

About