Deformation of membrane vesicles due to chiral surface proteins

Abstract

Chiral, rod-like molecules can self-assemble into cylindrical membrane tubules and helical ribbons. They have been successfully modeled using the theory of chiral nematics. Models have also predicted the role of...

Binding of anisotropic curvature-inducing proteins onto membrane tubes

“…This kind of chiral interaction can largely modify the protein assembly and membrane shape. 56,61 To reproduce them, additional interactions must be accounted for. However, for a sufficiently low protein density, such additional interactions are negligibly weak.…”

“…30 Several types of membrane models have been developed for coarse-grained simulations. [45][46][47] The protein binding has been investigated using molecular simulations, [48][49][50][51][52][53][54] dynamically triangulated membrane simulations, 55,56 and meshless membrane simulations. 40,41,[57][58][59][60][61] Among them, however, the binding effects on the axial force of a membrane tube have been investigated only by the meshless simulations; 41,57,59 a characteristic force dependence on the protein curvature was reported for homogeneous states at low protein curvatures, in addition to the protein assembly accompanied by membrane shape transformation at high protein curvatures.…”

Binding of anisotropic curvature-inducing proteins onto membrane tubes

“…In particular, BAR proteins typically form helical alignments in dense-packed conditions. Such a chiral interaction can largely modify the protein assembly and membrane shape [56,61]. To reproduce them, additional interactions are required to account for.…”

“…Several types of membrane models have been devel- oped for coarse-grained simulations [45][46][47]. The protein binding has been investigated using molecular simulations [48][49][50][51][52][53][54], dynamically triangulated membrane simulations [55,56], and meshless membrane simulations [40,41,[57][58][59][60][61]. Among them, however, the binding effects on the axial force of a membrane tube have been investigated only by the meshless simulations [41,57,59]; A characteristic force dependence on the protein curvature was reported for homogeneous states at low protein curvatures, in addition to the protein assembly accompanied by membrane shape transformation at high protein curvatures.…”

A human septin octamer complex sensitive to membrane curvature drives membrane deformation with a specific mesh-like organization

“…For example, artificially tuning the intrinsic curvature of FtsZ can trigger the emergence of either concave or convex deformations and tubulations on vesicles ( Osawa et al, 2009 ). However, membrane curvature and vesicle tubulation can also be induced by chiral nematics having no intrinsic curvature or bundling interaction ( Behera et al, 2021 ). Overall, application of this model to human septins allows us to rationalize our experimental observations of the orientation pattern of septins on rigid wavy surfaces as well the nature of deformations of vesicles.…”