Deformation of the Lamina Cribrosa and Anterior Scleral Canal Wall in Early Experimental Glaucoma

Bellezza, Anthony J.; Rintalan, Christopher J.; Thompson, Hilary W.; Downs, J. Crawford; Hart, Richard T.; Burgoyne, Claude F.

doi:10.1167/iovs.01-1282

Cited by 356 publications

(339 citation statements)

References 23 publications

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“…This discrepancy might have been due to the relative irreversibility of peripheral LC displacement, which has been proven by both an experimental animal model and with human glaucomatous eyes. 3,6,7 Among the POAG patients in the current investigation, the males had a significantly larger overall PLCD than did the females. Seo et al 21 reported increased anterior LC surface depth in males compared with females in healthy eyes.…”

Section: Discussionmentioning

confidence: 58%

“…[1][2][3][4][5][6][7] Under the biomechanical paradigm for glaucoma pathogenesis, the influence of increased intraocular pressure (IOP) on the LC has been widely elucidated in experimental glaucoma animal models. [7][8][9][10][11][12] Early experimental glaucoma monkey eyes, for example, showed posterior migration of anterior and posterior laminar insertion. 12 Posterior displacement of laminar insertion has been confirmed in autopsied and enucleated human eyes with advanced glaucoma.…”

Section: Introductionmentioning

confidence: 99%

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Peripheral lamina cribrosa depth in primary open-angle glaucoma: a swept-source optical coherence tomography study of lamina cribrosa

Kim

Jeoung

et al. 2015

Eye

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Purpose To investigate peripheral lamina cribrosa depth (PLCD) and its verticalhorizontal difference in eyes with primary open-angle glaucoma (POAG). Methods Patients with POAG (n = 90 eyes) and age-matched healthy individuals (n = 90 eyes) underwent swept-source optical coherence tomography (SS-OCT) scans centered at the optic discs. The PLCD was defined as the vertical distance between the most peripheral visible end of anterior lamina cribrosa (LC) surface and the reference plane connecting the Bruch's membrane openings. The PLCD in each quadrant region and the vertical-horizontal PLCD difference were compared between the POAG and healthy eyes. The clinical factors associated with increased PLCD were evaluated. Results The PLCD was significantly larger in the POAG eyes than the control eyes at the horizontal (P = 0.034) and vertical (P = 0.001) meridians. The vertical PLCD was significantly larger than the horizontal PLCD, both in the POAG eyes (Po0.001) and in the control eyes (P = 0.003). However, the vertical-horizontal PLCD difference was significantly larger in the POAG eyes (47 ± 60 μm) than in the control eyes (18 ± 54 μm, P = 0.001). Multivariate regression showed a significant association of male gender (P = 0.005), increased baseline IOP (P = 0.043), and decreased MD of VF (P = 0.025) with increased PLCD. Conclusions The peripheral LC was displaced more posteriorly in the POAG eyes compared with the age-matched healthy eyes. In the POAG eyes, the peripheral LC was displaced more posteriorly at the vertical meridian than at the horizontal meridian. The peripheral LC in the vertical meridian might have increased IOP-related strain (deformation) compared with horizontal meridian in glaucomatous eyes.

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Peripheral lamina cribrosa depth in primary open-angle glaucoma: a swept-source optical coherence tomography study of lamina cribrosa

Kim

Jeoung

et al. 2015

Eye

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“…Therefore, large disks may be more susceptible to pressure damage as per Laplace's law. 12,26 As the influence on disk size on the lamina cribrosa resistance and amount of connective tissue is complex, 12,25,26,27,149 further investigation is needed.…”

Section: Disk Size and Lamina Cribrosamentioning

confidence: 99%

Optic Disk Size and Glaucoma

Hoffmann

Zangwill

Crowston

et al. 2007

Survey of Ophthalmology

149

110

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Assessment of optic disk size is an important, but often overlooked, component of the diagnostic evaluation for glaucoma. Measured values of optic disk size vary with the measurement technique utilized. Available methods for disk size measurement and their respective strengths and limitations will be discussed. Further, actual disk size varies with race and possibly other demographic characteristics. Disk size is also associated with variation of specific anatomical structures of the optic nerve head and the retinal nerve fiber layer. These disk size-dependent variations may influence the susceptibility to glaucoma or the likelihood of glaucoma diagnosis. This manuscript reviews the published evidence relating to disk size and glaucoma.

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“…However, the biological and mechanical properties of the lamina cribrosa are complex, defined by contributions from astrocytes, lamina cribrosa cells and blood vessels embedded in a three-dimensional extracellular matrix. Thus, astrocytes and lamina cribrosa cells respond not only to external stimuli such as IOP but to the stiffness of the matrix within which they reside (Bellezza et al, 2003). Therefore, a cultured cell system is not a perfect model.…”

Section: Discussionmentioning

confidence: 99%

Differential Effects of Elevated Hydrostatic Pressure on Gene Expression and Protein Phosphorylation in Optic Nerve Head Astrocytes

Lukas¹,

Du²,

Miao³

et al. 2011

The Mystery of Glaucoma

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Deformation of the Lamina Cribrosa and Anterior Scleral Canal Wall in Early Experimental Glaucoma

Cited by 356 publications

References 23 publications

Peripheral lamina cribrosa depth in primary open-angle glaucoma: a swept-source optical coherence tomography study of lamina cribrosa

Peripheral lamina cribrosa depth in primary open-angle glaucoma: a swept-source optical coherence tomography study of lamina cribrosa

Optic Disk Size and Glaucoma

Differential Effects of Elevated Hydrostatic Pressure on Gene Expression and Protein Phosphorylation in Optic Nerve Head Astrocytes

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