Deformities of the Globus Pallidus are Associated with Severity of Suicidal Ideation and Impulsivity in Patients with Major Depressive Disorder

Kim, Ki-Won; Shin, Jeong Hee; Myung, Woojae; Fava, Maurizio; Mischoulon, David; Papakostas, George I.; Choi, Kee‐Joon; Na, Eun Jin; Seo, Sang Won; Seong, Joon Kyung; Jeon, Hong Jin

doi:10.1038/s41598-019-43882-4

Cited by 21 publications

(41 citation statements)

References 71 publications

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“…The major finding of this study was that the SA group had significant LSV alterations in the left putamen, left hippocampus, left amygdala, bilateral pallidum, and thalamus. Our findings are in line with the subcortical structural changes in suicidal depression (Ahearn et al, 2001; Monkul et al, 2007; Vang et al, 2010), despite studies with contradictory results (Gifuni et al, 2016; Jollant et al, 2018; Kim et al, 2019; Rentería et al, 2017). Compared with the NS group, the SA group showed significantly higher SSI, longer illness duration, and an increased number of past episodes.…”

Section: Discussionsupporting

confidence: 90%

“…Based on our demographic information, the SAs attempted suicide an average of 1.64 times with a maximum number of 7. Some studies proposed that suicidal behavior was associated with impulsivity (Kim et al, 2019). However, we found no significant correlation between the BIS and subcortical LSV changes.…”

Section: Discussionmentioning

confidence: 99%

“…Each subcortical structure was composed of 2,562 vertices. Further detailed information regarding this method had been described in previous reports (Chung et al, 2017; Kim et al, 2019; Koo et al, 2017; Shapira et al, 2008).…”

Section: Methodsmentioning

confidence: 99%

“…While some studies reported significant structural changes in subcortical regions in suicidal depressed patients (Ahearn et al, 2001; Vang et al, 2010), other studies failed to detect such changes (Gifuni et al, 2016; Jollant et al, 2018; Kim et al, 2019; Rentería et al, 2017). A meta‐analysis from the worldwide Enhancing NeuroImaging Genetics through Meta‐Analysis (ENIGMA) MDD working group (Rentería et al, 2017) reported no significant group differences in any of the subcortical volume measures between suicidal and nonsuicidal depression and suggested that many of the previous reports may be false positives.…”

Section: Introductionmentioning

confidence: 99%

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Local shape volume alterations in subcortical structures of suicide attempters with major depressive disorder

Kang

Shin

Han

et al. 2020

Human Brain Mapping

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Suicide is among the most important global health concerns; accordingly, an increasing number of studies have shown the risks for suicide attempt(s) in terms of brain morphometric features and their clinical correlates. However, brain studies addressing suicidal vulnerability have been more focused on demonstrating impairments in cortical structures than in the subcortical structures. Using local shape volumes (LSV) analysis, we investigated subcortical structures with their clinical correlates in depressed patients who attempted suicide. Then we compared them with depressed patients without a suicidal history and age‐ and sex‐matched healthy controls (HCs; i.e., 47 suicide attempters with depression, 47 non‐suicide attempters with depression, and 109 HCs). Significant volumetric differences were found between suicidal and nonsuicidal depressed patients in several vertices: 16 in the left amygdala; 201 in the left hippocampus; 1,057 in the left putamen; and 140 in the left pallidum; 1 in the right pallidum; and 6 in the bilateral thalamus. These findings indicated subcortical alterations in LSV in components of the limbic–cortical–striatal–pallidal–thalamic circuits. Moreover, our results demonstrated that the basal ganglia was correlated with perceived stress levels, and the thalamus was correlated with suicidal ideation. We suggest that suicidality in major depressive disorder may involve subcortical volume alterations.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Local shape volume alterations in subcortical structures of suicide attempters with major depressive disorder

Kang

Shin

Han

et al. 2020

Human Brain Mapping

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“…They mainly investigated whether specific structural differences were present in MDD patients with and without suicidal ideation and identified biological features related to suicidal risk. 25 These biological features might be the basis for demonstrating that cognitive function may also be affected in mood disorder patients with suicidal ideation. In this study, we intended to examine the performance of attention tests related to suicidal ideation in mood disorder patients and to explain the difference of attention test performance reflecting impulsivity in relation to suicidal ideation after controlling clinical and psychological variables of mood disorder patients.…”

Section: The Relationship Between Performance Of Attention Task and Smentioning

confidence: 99%

The Relationship between Performance of Attention Task and Suicidal Ideation in Korean Patients with Mood Disorders

Kim

Kong

2020

Psychiatry Investig

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Objective We examined the performance of attention tests related to suicidal ideation in mood disorder patients and to explain the difference of attention test performance in relation to suicidal ideation after controlling clinical and psychological variables of mood disorder patients.Methods Seventy-three in- and outpatients with major depressive disorder (n=41) or bipolar disorder (n=32) completed a self-rating questionnaire assessing socio-demographic characteristics, and clinical and psychological variables. Comprehensive Attention Test (CAT) also was conducted.Results Thirty-three patients were the high-suicidal ideation (SI) group, and forty patients were the low-SI group. The errors of commission (CEs) of visual sustained attention in the high-SI group was 6.3 times higher on average than that of the low-SI group. After controlling for sex, age, and diagnosis, a higher number of CEs on visual sustained attention tasks predicted higher SI score. However, after controlling for sex, age, diagnosis, and depressive mood, this predictive ability was no longer observed.Conclusion This study showed that CE on the visual sustained attention task seems to influence suicidal ideation as a result of interaction with depressive symptoms.

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Topological differences of striato‐thalamo‐cortical circuit in functional brain network between premature ejaculation patients with and without depression

Zhang,

Niu,

et al. 2024

Brain and Behavior

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IntroductionPremature ejaculation (PE), a common male sexual dysfunction, often accompanies by abnormal psychological factors, such as depression. Recent neuroimaging studies have revealed structural and functional brain abnormalities in PE patients. However, there is limited neurological evidence supporting the comorbidity of PE and depression. This study aimed to explore the topological changes of the functional brain networks of PE patients with depression.MethodsResting‐state functional magnetic resonance imaging (rs‐fMRI) data were acquired from 60 PE patients (30 with depression and 30 without depression) and 29 healthy controls (HCs). Functional brain networks were constructed for all participants based on rs‐fMRI data. The nodal parameters including nodal centrality and efficiency were calculated by the method of graph theory analysis and then compared between groups. In addition, the results were corrected for multiple comparisons by family‐wise error (FWE) (p < .05).ResultsPE patients with depression had increased degree centrality and global efficiency in the right pallidum, as well as increased degree centrality in the right thalamus when compared with HCs. PE patients without depression showed increased degree centrality in the right pallidum and thalamus, as well as increased global efficiency in the right precuneus, pallidum, and thalamus when compared with HCs. PE patients with depression demonstrated decreased degree centrality in the right pallidum and thalamus, as well as decreased global efficiency in the right precuneus, pallidum, and thalamus when compared to those without depression. All the brain regions above survived the FWE correction.ConclusionThe results suggested that increased and decreased functional connectivity, as well as the capability of global integration of information in the brain, might be related to the occurrence of PE and the comorbidity depression in PE patients, respectively. These findings provided new insights into the understanding of the pathological mechanisms underlying PE and those with depression.

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Deformities of the Globus Pallidus are Associated with Severity of Suicidal Ideation and Impulsivity in Patients with Major Depressive Disorder

Cited by 21 publications

References 71 publications

Local shape volume alterations in subcortical structures of suicide attempters with major depressive disorder

Local shape volume alterations in subcortical structures of suicide attempters with major depressive disorder

The Relationship between Performance of Attention Task and Suicidal Ideation in Korean Patients with Mood Disorders

Topological differences of striato‐thalamo‐cortical circuit in functional brain network between premature ejaculation patients with and without depression

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