2023
DOI: 10.1101/2023.10.04.560923
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DegCre: Probabilistic association of differential gene expression with regulatory regions

Brian S. Roberts,
Gregory M. Cooper,
Richard M. Myers

Abstract: Differential gene expression in response to perturbations is mediated at least in part by changes in binding of transcription factors (TFs) and other proteins at specific genomic regions. Association of these cis-regulatory elements (CREs) with their target genes is a challenging task that is essential to address many biological and mechanistic questions. Many current approaches rely on chromatin conformation capture techniques that identify spatial proximity between genomic sites to establish CRE-to-gene asso… Show more

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