Degenerative aortic stenosis

Ramaraj, Radhakrishnan; Sorrell, Vincent L.

doi:10.1136/bmj.39478.498819.ad

Cited by 45 publications

(53 citation statements)

References 28 publications

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“…The perioperative complication risk increases considerably in particular in the elderly patients with comorbid diseases such as COPD, pulmonary hypertension, renal failure, heart failure, previous cardiac surgery and consequently the perioperative mortality risk also increases. For this reason, 30% of the patients were not operated in the past, despite having first degree indication (5)(6)(7)(8).…”

Section: Diagnosis Of Aortic Valve Stenosis and Indications Of Tavimentioning

confidence: 99%

Transcatheter Aortic Valve Implantation: Our Experience and Review of the Literature

Burgazli¹,

Chasan²,

Kavukçu³

et al. 2012

Balkan Med J

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Section: Diagnosis Of Aortic Valve Stenosis and Indications Of Tavimentioning

confidence: 99%

Transcatheter Aortic Valve Implantation: Our Experience and Review of the Literature

Burgazli¹,

Chasan²,

Kavukçu³

et al. 2012

Balkan Med J

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“…Elderly aortic stenosis sufferers present significant symptom burden, which includes exertional breathlessness, dizziness, chest pains, and syncope [6,7]. According to the World Health Organisation definition of QoL, it is an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards, and concerns.…”

Section: Introductionmentioning

confidence: 99%

Improvement of quality of life following transcatheter aortic valve implantation in the elderly: a multi-centre study based on the Polish national TAVI registry

et al. 2017

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A b s t r a c tBackground: Transcatheter aortic valve implantation (TAVI) is an effective therapeutic method for elderly high-risk patients with symptomatic severe aortic stenosis, not eligible for surgical treatment. Aim:The aim of the study was to evaluate short-term changes in elderly people's quality of life following TAVI, based on the POL-TAVI registry. Methods:One hundred and eighty-four octogenarians' and nonagenarians' samples from the POL-TAVI database were included in the study. The quality of life status was assessed with EQ-5D-3L questionnaire at baseline and after one-month follow-up. Results:The mean of patients' age was 84 (80-93) years. Logistic EuroSCORE mean was 19.83% (3.48-83.94%), and transaortic mean gradient was 54.99 (19.0-149.0) mm Hg. At baseline, up to 24.50% of patients declared severe problems in performing usual activities. 13.60% felt extreme pain or discomfort; 9.80% were unable to wash and dress by themselves; 8.20% were extremely anxious or depressed; and 7.10% of the patients in the study were confined to bed. After 30 days the percentage of patients declaring severe problems in each dimension did not exceed 4.00%. The comparison between quality of life data at baseline and after one-month follow-up showed a significant improvement in each of five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression (p < 0.001). Patients' quality of life was increasing regardless of gender (female vs. male), the type of anaesthesia (general vs. local), and the type of procedure (TA vs. TF). Conclusions:Short-term quality of life in the elderly subjects was significantly improved after one-month follow-up following TAVI.

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“…Heavy calcification is associated with hemodynamic impairment leading ultimately to need for valve replacement [7]. polymorphisms and activation of certain pathways such as renin-angiotensin system seem to play vital role and elucidation of their participation in pathophysiology of CAS comprises major challenge [2,6].…”

Section: Anatomy -Histologymentioning

confidence: 99%

“…Tricuspid aortic valve is a flexible membrane that opens and closes 100,000 times a day ( Aortic stenosis is the most common valvular lesion in Europe and North America [2]. As incidence of acute rheumatic fever has declined, calcific aortic stenosis (CAS) has become the most common indication for surgical valve replacement in the United States (Fig.…”

Section: Introductionmentioning

confidence: 99%