Degenerative osteoarthritis a reversible chronic disease

Nicola, Valerio Di

doi:10.1016/j.reth.2020.07.007

Cited by 67 publications

(79 citation statements)

References 110 publications

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“…Literature shows that PRP can stimulate an antiinflammatory, proliferative and remodelling response inducing mesenchymal tissue regeneration [2]. Specifically, in osteoarthritis (OA), chondrogenic differentiating properties were found in vitro as well as in vivo in mice and rabbits, indicating a major role in regeneration of cartilage [3][4][5][6][7].…”

Section: Materials Employedmentioning

confidence: 99%

“…For autologous MSCs treatments in OA and plastic-aesthetic surgery the use of adipose tissue-derived stem cells (ASCs) is the most common and the most studied. The use of peripheral blood stem cells (PBSCs) is becoming popular [2].…”

Section: Mscs Therapymentioning

confidence: 99%

“…Chronic pain leading to disability is the most common direct consequence. OA is the single most common cause of disability in older adults [2].…”

Section: Who Are the Rsu Patients? A Focus On Oa And Hernia Repairmentioning

confidence: 99%

“…Joint replacement cannot often be offered to frail elderly patients (ASA III-IV) due to high risks of complications and increased mortality. Likewise, surgeons are reluctant to offer to younger patient's joint replacement due to the limited life span of prosthesis and chronic postural imbalance induced by the new joint [2]. The result is the increasing consumption of chronic medications such as NSAIDs and opioids in socalled pain management.…”

Section: Who Are the Rsu Patients? A Focus On Oa And Hernia Repairmentioning

confidence: 99%

“…The result is the increasing consumption of chronic medications such as NSAIDs and opioids in socalled pain management. This palliation has a severe systemic backlash on patient care and health systems due to the complications related to chronic NSAIDs and opioids intake and addiction [2].…”

Section: Who Are the Rsu Patients? A Focus On Oa And Hernia Repairmentioning

confidence: 99%

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Regenerative Surgery Unit (RSU) a new model of care

Nicola¹

2020

Biomed Res Clin Prac

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Regenerative Surgery (RS) defines all the Regenerative Medicine (RM) treatments that can be applied through minimally invasive surgical procedures. This biomedical approach includes the use of stem cells, various local biochemical mediators, and tissue engineering.The Regenerative Surgery Unit (RSU) is a new model of health care governance integrating clinical, scientific and research activities.RSU works in a multidisciplinary setting involving surgeon, biologist, immunologist, laboratory technician, radiologist, and physiotherapist.RSU setting also aims to generate a special relation between doctor and patient. The aim of this relationship is to establish a solid and mutually beneficial alliance, founded on medical ethics, between doctor and patient.RSU organises clinical services through ambulatory care and day surgery settings. The scientific and research activities are integrated as components of daily medical practice.This article describes some established procedures in RS and some refinements that are more recently available as a result of our clinical and research experience in RM fields.Health Tourism is one element of the sustainable growth model we are developing in the RSU-Villa Aurora Hospital, Foligno (Italy).

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Section: Materials Employedmentioning

confidence: 99%

Section: Mscs Therapymentioning

confidence: 99%

“…Chronic pain leading to disability is the most common direct consequence. OA is the single most common cause of disability in older adults [2].…”

Section: Who Are the Rsu Patients? A Focus On Oa And Hernia Repairmentioning

confidence: 99%

Section: Who Are the Rsu Patients? A Focus On Oa And Hernia Repairmentioning

confidence: 99%

Section: Who Are the Rsu Patients? A Focus On Oa And Hernia Repairmentioning

confidence: 99%

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Regenerative Surgery Unit (RSU) a new model of care

Nicola¹

2020

Biomed Res Clin Prac

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Nanomedicines Reprogram Synovial Macrophages by Scavenging Nitric Oxide and Silencing CA9 in Progressive Osteoarthritis

Yan

Dou

et al. 2023

Advanced Science

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Osteoarthritis (OA) is a progressive joint disease characterized by inflammation and cartilage destruction, and its progression is closely related to imbalances in the M1/M2 synovial macrophages. A two‐pronged strategy for the regulation of intracellular/extracellular nitric oxide (NO) and hydrogen protons for reprogramming M1/M2 synovial macrophages is proposed. The combination of carbonic anhydrase IX (CA9) siRNA and NO scavenger in “two‐in‐one” nanocarriers (NAHA‐CaP/siRNA nanoparticles) is developed for progressive OA therapy by scavenging NO and inhibiting CA9 expression in synovial macrophages. In vitro experiments demonstrate that these NPs can significantly scavenge intracellular NO similar to the levels as those in the normal group and downregulate the expression levels of CA9 mRNA (≈90%), thereby repolarizing the M1 macrophages into the M2 phenotype and increasing the expression levels of pro‐chondrogenic TGF‐β1 mRNA (≈1.3‐fold), and inhibiting chondrocyte apoptosis. Furthermore, in vivo experiments show that the NPs have great anti‐inflammation, cartilage protection and repair effects, thereby effectively alleviating OA progression in both monoiodoacetic acid‐induced early and late OA mouse models and a surgical destabilization of medial meniscus‐induced OA rat model. Therefore, the siCA9 and NO scavenger “two‐in‐one” delivery system is a potential and efficient strategy for progressive OA treatment.

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The potential role of synovial cells in the progression and treatment of osteoarthritis

Zou

Han

Yang³

et al. 2023

Exploration

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Osteoarthritis (OA), the commonest arthritis, is characterized by the progressive destruction of cartilage, leading to disability. The Current early clinical treatment strategy for OA often centers on anti‐inflammatory or analgesia medication, weight loss, improved muscular function and articular cartilage repair. Although these treatments can relieve symptoms, OA tends to be progressive, and most patients require arthroplasty at the terminal stages of OA. Recent studies have shown a close correlation between joint pain, inflammation, cartilage destruction and synovial cells. Consequently, understanding the potential mechanisms associated with the action of synovial cells in OA could be beneficial for the clinical management of OA. Therefore, this review comprehensively describes the biological functions of synovial cells, the synovium, together with the pathological changes of synovial cells in OA, and the interaction between the cartilage and synovium, which is lacking in the present literature. Additionally, therapeutic approaches based on synovial cells for OA treatment are further discussed from a clinical perspective, highlighting a new direction in the treatment of OA.

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Degenerative osteoarthritis a reversible chronic disease

Cited by 67 publications

References 110 publications

Regenerative Surgery Unit (RSU) a new model of care

Regenerative Surgery Unit (RSU) a new model of care

Nanomedicines Reprogram Synovial Macrophages by Scavenging Nitric Oxide and Silencing CA9 in Progressive Osteoarthritis

The potential role of synovial cells in the progression and treatment of osteoarthritis

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