Degradable Hemostatic Antibacterial Zein Nanofibrous Mats as Anti‐Adhesive Wound Dressing

Abstract

Strong blood adhesion to dressing may cause secondary damage to the wounds during the wound dressing replacement process. Thus, blood repellent dressings have significant potential applications in wound treatment. Herein, a hydrophobic, degradable, and antibacterial dressing is reported to reduce the blood adhesion and prevent infection around the wounds. The dressing is prepared by cross‐linked non‐woven zein nanofibers with quaternized titanium dioxide (TiO2) nanoparticles coating. The dual hydrophobic structures supported by zein nanofibers and the quaternized TiO2 nanoparticles coating provide outstanding water/blood repellency for the dressing, and efficiently prevent blood leakage. Meanwhile, the dressing also possesses appropriate moisture permeability (2194 ± 143 mL m−2 per day). In addition, the quaternized TiO2 nanoparticles coating provides excellent bactericidal activity against Gram‐negative Escherichia coli O157:H7 and Gram‐positive Staphylococcus aureus, especially under visible Xe lamp illumination. Evaluations of hemolysis and cytocompatibility confirm that the fabricated mat is biocompatible and non‐toxic to the cells. Considering the excellent degradable features, the dressing may become a promising environmentally friendly biomedical material.

Nanofibrous Dressing with Nanocomposite Monoporous Microspheres for Chemodynamic Antibacterial Therapy and Wound Healing

“…The WCA of the nanocomposite dressing decreased by approximately 10°, possibly due to the hydrophilic nature of the NPs . Overall, the hydrophobic wound dressing developed here was expected to have the advantage of not adhering to the wound . In addition, the mechanical properties of the nanofibrous dressings were evaluated.…”

“… 51 Overall, the hydrophobic wound dressing developed here was expected to have the advantage of not adhering to the wound. 52 In addition, the mechanical properties of the nanofibrous dressings were evaluated. As shown in Figure 4 f, the fracture stress of the pure PCL nanofibrous dressing was 6.79 MPa, whereas those of MgO/Ag-PCL and MgO/Cu-PCL increased by 2.34 and 1.52 MPa, respectively.…”

Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

“…[1][2][3][4][5][6][7][8] Today, nano techniques are frequently introduced into drug delivery fields for not only renewing the drug delivery systems, [9][10][11][12][13] but also resolving the most difficult pharmaceutical challenges. [14][15][16][17][18] Among them, the dissolution DOI: 10.1002/mame.202300361 of poorly water-soluble drugs and their related controlled release profiles are drawing increasing attention. [19][20][21][22] Particularly, the fast or pulsatile release, one type of ratecontrolled release profile (Figure 1), has the advantages of rapid release for achieving a rapid therapeutic action for many diseases such as fever, aches, and emotional irritability.…”

Zein/hydroxypropylcellulose biofilms with hydrophilic and hydrophobic montmorillonite clays

“…[10] In this context, zein composites and nanocomposites have received special consideration in recent years due to their large availability and the great potential to obtain material with singular applications, such as improved mechanical, thermal, barrier, antibacterial activities and surface features, especially for edible food film applications. [11][12][13] Zein is an endosperm-derived protein of corn grains, characterized by its high non-polar amino acid content, providing hydrophobic molecular structure. This macromolecule shows affinity for hydroalcoholic solutions with content between 60% and 95%, in which chains partially open their helix structures, allowing interactions between the solvent and polymer chains via hydrogen bonds.…”