Degradable hydrogels: Design mechanisms and versatile applications

Hosseinzadeh, Batoul; Ahmadi, Mostafa

doi:10.1016/j.mtsust.2023.100468

Cited by 12 publications

(2 citation statements)

References 171 publications

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“…Conversely, the three‐dimensional matrix of the chemical gels is formed by chemical bonds between single or multiple monomers present in the system, [36] conferring a stable chemical structure to the hydrogel. In this way, the final gels display stronger mechanical properties and lower degradation kinetics, whereas they are still degradable [37] . Hydrogels have found applications in many fields, especially in the biomedical one.…”

Section: Hydrogels: Main Properties and Current Limitationsmentioning

confidence: 99%

Last Advances on Hydrogel Nanoparticles Composites in Medicine: An Overview with Focus on Gold Nanoparticles

Molinelli,

Schirato,

Moretti

et al. 2024

ChemNanoMat

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Hydrogel nanocomposites have lately taken part in the biomaterials scenario for several applications in the biomedical field, e.g., drug delivery, biosensing and cancer therapy. The inclusion of a broad variety of nanomaterials inside the hydrogel matrix leads to the successful development of hybrid platforms with superior and advantageous features. In this way, finely designed nano‐systems can be obtained, which are able to overcome the intrinsic limitations of conventional hydrogels, such as weak mechanical properties, burst drug delivery, extremely high hydrophilicity and lack of multifunctionality. This review aims to outline the last advances in the manufacturing of nanocomposite systems and their novel applications to the biomedical field, providing an overview of the most used nanoparticles with a special focus on gold nanoparticles.

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Section: Hydrogels: Main Properties and Current Limitationsmentioning

confidence: 99%

Last Advances on Hydrogel Nanoparticles Composites in Medicine: An Overview with Focus on Gold Nanoparticles

Molinelli,

Schirato,

Moretti

et al. 2024

ChemNanoMat

View full text Add to dashboard Cite

show abstract

“…In addition, the vicinal diol in hyaluronic acid can be oxidized to aldehyde groups by sodium periodate to form aldehyde-hyaluronic acid, and chitosan-hyaluronic acid hydrogel was formed through Schiff's base cross-linking for the immobilization of insulin-like growth factor 1, which improved stem cell therapy for limb ischemia [94]. Moreover, hyaluronidase can promote the decomposition of hyaluronic acid, and its concentration was found to be remarkably higher in various cancerous cells [95]. Thus, hyaluronic acid-based hydrogels are commonly degradable and can be used as a local therapy carrier.…”

Section: Starch and Starch-based Hydrogelmentioning

confidence: 99%

Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications

Zhao,

Zhou,

Zhang

et al. 2023

Pharmaceutics

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Hydrogels prepared from natural polymer have attracted extensive attention in biomedical fields such as drug delivery, wound healing, and regenerative medicine due to their good biocompatibility, degradability, and flexibility. This review outlines the commonly used natural polymer in hydrogel preparation, including cellulose, chitosan, collagen/gelatin, alginate, hyaluronic acid, starch, guar gum, agarose, and dextran. The polymeric structure and process/synthesis of natural polymers are illustrated, and natural polymer-based hydrogels including the hydrogel formation and properties are elaborated. Subsequently, the biomedical applications of hydrogels based on natural polymer in drug delivery, tissue regeneration, wound healing, and other biomedical fields are summarized. Finally, the future perspectives of natural polymers and hydrogels based on them are discussed. For natural polymers, novel technologies such as enzymatic and biological methods have been developed to improve their structural properties, and the development of new natural-based polymers or natural polymer derivatives with high performance is still very important and challenging. For natural polymer-based hydrogels, novel hydrogel materials, like double-network hydrogel, multifunctional composite hydrogels, and hydrogel microrobots have been designed to meet the advanced requirements in biomedical applications, and new strategies such as dual-cross-linking, microfluidic chip, micropatterning, and 3D/4D bioprinting have been explored to fabricate advanced hydrogel materials with designed properties for biomedical applications. Overall, natural polymeric hydrogels have attracted increasing interest in biomedical applications, and the development of novel natural polymer-based materials and new strategies/methods for hydrogel fabrication are highly desirable and still challenging.

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Injectable Hydrogels for Programmable Nanoparticle Release

Shi,

Ying,

Sheng

et al. 2024

Adv Funct Materials

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Injectable hydrogels represent a promising strategy for the extended release of biological molecules, thereby reducing the frequency of injections. This study introduces a novel system based on Michael addition of dextran and polyethylene glycol (PEG) polymers functionalized with oxanorbornadiene (OND) and thiol groups, respectively. Reliable control over gelation speed allows administration by injection using a simple syringe‐to‐syringe mixing protocol that entrains more than 95% of virus‐like particle (VLP) cargo. A combination of retro‐Diels‐Alder and hydrolytic ester bond cleavage gives rise to programmable release of the VLPs. Different release profiles, including burst, linear, and delayed release over a two‐week period, are engineered using different OND linkages, and rheological characterization shows the hydrogels to be well within the desired range of stiffness for subcutaneous use. The modular nature of this system offers a generalizable platform for developing degradable materials aimed at sustained release biomedical applications.

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Degradable hydrogels: Design mechanisms and versatile applications

Cited by 12 publications

References 171 publications

Last Advances on Hydrogel Nanoparticles Composites in Medicine: An Overview with Focus on Gold Nanoparticles

Last Advances on Hydrogel Nanoparticles Composites in Medicine: An Overview with Focus on Gold Nanoparticles

Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications

Injectable Hydrogels for Programmable Nanoparticle Release

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