Degradable microneedle patches loaded with antibacterial gelatin nanoparticles to treat staphylococcal infection-induced chronic wounds

Lei, Xiaofei; Li, Mengjin; Wang, Cheng; Cui, Pengfei; Qiu, Lin; Zhou, Shuwen; Jiang, Pengju; Li, Haihang; Zhao, Donghui; Ni, Xiaomin; Wang, Jianhao; Xia, Jiang

doi:10.1016/j.ijbiomac.2022.07.021

Cited by 37 publications

(23 citation statements)

References 44 publications

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“…AMP (KKLRLKIAFK) was synthesized by Fmoc solid-phase synthesis according to the previous work of our laboratory. 32 The m/z of [M + 2H] 2+ (734.2) and [M + 3H] 3+ (489.6) was measured by liquid chromatography−mass spectrometry (LC−MS) and found to be similar to the calculated values (734.425, and 489.95), indicating the successful synthesis of AMP.…”

Section: Materials and Microbial Strainsmentioning

confidence: 80%

Antimicrobial Peptide Nanoparticle-Based Microneedle Patches for the Treatment of Bacteria-Infected Wounds

Wang

Zhao

et al. 2023

ACS Appl. Nano Mater.

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To avoid the production of drug resistance during the antibiotic treatment of wound infection, the use of antimicrobial peptides (AMPs) has been strongly developed. However, its application is limited by low bioavailability, rapid degradation of AMP, and the difficulty of deep-tissue bacterial elimination. To solve this problem, AMP and recombinant type III humanized collagen (Col III)-contained microneedle patches were designed to achieve slow and controlled release of AMP and Col III to effectively eliminate the bacteria in the deep wound tissue and promote wound healing. AMP (KKLRLKIAFK) coupled with Cy3 was encapsulated in the nanogel (CGA-NPs), which was formed by chitosan (CS) and gum arabic (GA) through electrostatic interactions. Microneedle (MN) patches were dissolved after penetrating the infected skin and biofilm formed by Staphylococcus aureus to release CGA-NPs. AMPs was released responding to the infected microenvironment to efficiently kill bacteria, and Col III was beneficial to promote wound healing. This is a strategy for the design and application of a microneedle-based antimicrobial drug delivery system.

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Section: Materials and Microbial Strainsmentioning

confidence: 80%

Antimicrobial Peptide Nanoparticle-Based Microneedle Patches for the Treatment of Bacteria-Infected Wounds

Wang

Zhao

et al. 2023

ACS Appl. Nano Mater.

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“…Compared to other groups, the rhCol III EN NF groups contained more type III collagen, suggesting a reduction in scar contracture and sclerosis. 57 According to the aforementioned research, rhCol III EN NF enhanced collagen deposition in the neonatal skin tissue, thereby expediting wound healing and minimizing scarring (Fig. 7(C)).…”

Section: Regulation Of Collagen Deposition In the Wound Areamentioning

confidence: 90%

Electrospun nanofibrous membranes of recombinant human collagen type III promote cutaneous wound healing

Dong,

Liu,

Han

et al. 2023

J. Mater. Chem. B

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“…Xia et al. encapsulated gelatin nanoparticles modified with the gelatinase-responsive antimicrobial photothermal peptide AMP-Cypate in dissolving MNs [ 78 ]. When applied to the infected site, the MNs broke through the epidermis and stratum corneum and released the nanoparticles after dissolving.…”

Section: Design Principles Of Functional Mns For Istrmentioning

confidence: 99%

Microneedles for in situ tissue regeneration

Long¹,

Ji²,

Hu³

et al. 2023

Materials Today Bio

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Degradable microneedle patches loaded with antibacterial gelatin nanoparticles to treat staphylococcal infection-induced chronic wounds

Cited by 37 publications

References 44 publications

Antimicrobial Peptide Nanoparticle-Based Microneedle Patches for the Treatment of Bacteria-Infected Wounds

Antimicrobial Peptide Nanoparticle-Based Microneedle Patches for the Treatment of Bacteria-Infected Wounds

Electrospun nanofibrous membranes of recombinant human collagen type III promote cutaneous wound healing

Microneedles for in situ tissue regeneration

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