Degradable nanohydrogel with high doxorubicin loadings exhibiting controlled drug release and decreased toxicity against healthy cells

Waleka, Ewelina; Maćkiewicz, Marcin; Romański, J.; Dybko, Artur; Stojek, Zbigniew; Karbarz, Marcin

doi:10.1016/j.ijpharm.2020.119188

Cited by 16 publications

(7 citation statements)

References 43 publications

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“…Other important DDS factors to improve the effectiveness and safety of therapy include controlling the timing, rate, and location of the drug release and minimizing the impact on healthy cells in other parts of the body. 23,24 Hydrogel drug delivery depots can have different concepts to incorporate active agents in the polymer matrix. On the one hand, it is possible to introduce an interaction between the polymer network and the active ingredient.…”

Section: Introductionmentioning

confidence: 99%

3D printed and stimulus responsive drug delivery systems based on synthetic polyelectrolyte hydrogels manufactured via digital light processing

et al. 2023

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Section: Introductionmentioning

confidence: 99%

3D printed and stimulus responsive drug delivery systems based on synthetic polyelectrolyte hydrogels manufactured via digital light processing

et al. 2023

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“…The cytotoxicity abilities of DOX loaded- and pure NGs against breast cancer- (MCF-7) and healthy cell lines (MCF-10A) were investigated using the MTT assay (Waleka et al., 2020 ). Briefly, both cell lines were seeded onto 96- well culture plates with a density of 104 cells per well.…”

Section: Methodsmentioning

confidence: 99%

Enzyme-triggered- and tumor-targeted delivery with tunable, methacrylated poly(ethylene glycols) and hyaluronic acid hybrid nanogels

et al. 2022

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Enzyme-responsive polymeric-based nanostructures are potential candidates for serving as key materials in targeted drug delivery carriers. However, the major risk in their prolonged application is fast disassembling of the short-lived polymeric-based structures. Another disadvantage is the limited accessibility of the enzyme to the moieties that are located inside the network. Here, we report on a modified environmentally responsive and enzymatically cleavable nanogel carrier that contains a hybrid network. A properly adjusted volume phase transition (VPT) temperature allowed independent shrinking of a) poly(ethylene glycol) methyl ether methacrylate (OEGMA) with di(ethylene glycol) and b) methyl ether methacrylate (MEO 2 MA) part of the network, and the exposition of hyaluronic acid methacrylate (MeHa) network based carboxylic groups for its targeted action with the cellular based receptors. This effect was substantial after raising temperature in typical hyperthermia-based treatment therapies. Additionally, novel tunable NGs gained an opportunity to store- and to efficient-enzyme-triggered release relatively low but highly therapeutic doses of doxorubicin (DOX) and mitoxantrone (MTX). The controlled enzymatic degradation of NGs could be enhanced by introducing more hyaluronidase enzyme (HAdase), that is usually overexpressed in cancer environments. MTT assay results revealed effective cytotoxic activity of the NGs against the human MCF-7 breast cancer cells, the A278 ovarian cancer cells and also cytocompatibility against the MCF-10A and HOF healthy cells. The obtained tunable, hybrid network NGs might be used as a useful platform for programmed delivery of other pharmaceuticals and diagnostics in therapeutic applications.

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“…Many patients may simply not be aware that they have kidney problems (Gubler, 2002;Spoorthy et al, 2020). But the matter may be in the excessive activation of the immune system: upon discovering an unfamiliar infection, it begins to attack not only the virus itself but also the healthy cells of its own body, including such a sensitive organ as the kidneys (Waleka et al, 2020;Metaxa et al, 2014).…”

Section: Blood Coagulation Systemmentioning

confidence: 99%

Kidney complications after COVID-19

Rahkmonova

Khaytboyev

Zargarova

et al. 2021

ijhs

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This article discusses renal complications after Covid-19. It has now become clear that infection with the SARS-Cov-2 virus, which causes COVID-19, is almost identical - and this tells scientists which organs are most at risk. Specifically, the respiratory tract, intestines and, most likely, the kidneys, since it is there that both proteins necessary for the virus are present. Even the Ebola virus, found in the eye fluid of ex-patient’s months after recovery, causes blindness in 40 percent of those infected later. Therefore, given that SARS-CoV-2 is more likely to damage the lungs, doctors have speculated that the virus may cause irreversible changes in the respiratory system.

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Degradable nanohydrogel with high doxorubicin loadings exhibiting controlled drug release and decreased toxicity against healthy cells

Cited by 16 publications

References 43 publications

3D printed and stimulus responsive drug delivery systems based on synthetic polyelectrolyte hydrogels manufactured via digital light processing

3D printed and stimulus responsive drug delivery systems based on synthetic polyelectrolyte hydrogels manufactured via digital light processing

Enzyme-triggered- and tumor-targeted delivery with tunable, methacrylated poly(ethylene glycols) and hyaluronic acid hybrid nanogels

Kidney complications after COVID-19

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