Degradable polymers may improve dental practice

Battistella, Elisa; Varoni, Elena Maria; Cochis, Andrea; Palazzo, Barbara; Rimondini, Lia

doi:10.5301/jabb.2011.8867

Cited by 31 publications

(36 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chitosan (CS) and hyaluronic acid (HA) are interesting biopolymers for developing biomimetic extracellular matrices for any defect size and shape for periodontium tissue regeneration. 6,[13][14][15] CS is a polysaccharide structurally similar to glycosaminoglycans (GAG) present in the natural extracellular matrix and HA is the GAG's backbone responsible for tissue hydration. HA has low mechanical strength and rapid bioresorption in tissues, whereas CS has good mechanical properties but longer bioresorption.…”

Section: Introductionmentioning

confidence: 99%

A chitosan‐hyaluronic acid hydrogel scaffold for periodontal tissue engineering

et al. 2015

View full text Add to dashboard Cite

The current challenge in treating periodontitis is regenerating the periodontium. This motivates tissue-engineering researchers to develop scaffolds as artificial matrices that give mechanical support for osteoblasts, cementoblasts, gingival and periodontal ligament fibroblast cells. In this study, modified hyaluronic acid (HA) and chitosan (CS) were employed to create a hybrid CS-HA hydrogel scaffold for periodontal regeneration. CS, HA, and CS-HA scaffolds were obtained by freeze-drying technique, resulting in porous structures suitable for use in tissue engineering. Scaffolds were submitted to gamma and UV-sterilization without significant morphology changes. The ATR-FTIR spectra of CS-HA hydrogels showed peaks at 377 cm , 1566 cm , and 1614 cm , representing secondary amide, primary amine, and carboxyl acid respectively, and it was also observed the emergence of peaks at 886 cm , which probably represents the Schiff base formed in the case of hybrid CS-HA hydrogels. The scaffolds presented a high rate of PBS uptake, reaching values higher than 95%. Thermal degradation of HA scaffolds was around 225°C and CS was around 285°C. The ATR-FTIR spectra and swelling degree were slightly disturbed mainly after gamma sterilization, but degradation temperature did not change after sterilization. The performance of the CS-HA hydrogel scaffolds for in vitro cell culture was tested using NIH3T3 and MG63 cell lines. The Alamar Blue test showed a significant increase in cellular viability and high CD44 expression, suggesting that the cells migrated more when seeded onto the scaffolds. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1691-1702, 2016.

show abstract

Section: Introductionmentioning

confidence: 99%

A chitosan‐hyaluronic acid hydrogel scaffold for periodontal tissue engineering

et al. 2015

View full text Add to dashboard Cite

show abstract

“…A localized treatment with antibiotics provides a sustained release. Typical coating matrices for controlled release systems are polyesters such as poly-ε-caprolactone, 99 biodegradable polymers such as alginate, poly(lactic acid), poly(glycolic acid), 100 and carbonated hydroxyapatite. 101,102 Biodegradable polymers are extensively employed in periodontal drug delivery devices due to their abundance, lack of toxicity, and high biocompatibility.…”

Section: Peri-implantitis Prevention: Antimicrobial Coatingsmentioning

confidence: 99%

Current state‐of‐the‐art and future perspectives of the three main modern implant‐dentistry concerns: Aesthetic requirements, mechanical properties, and peri‐implantitis prevention

López‐Píriz

Cabal

Goyos‐Ball³

et al. 2019

J Biomedical Materials Res

View full text Add to dashboard Cite

The idea of permanent tooth replacement goes back to the year 2000 BC at least, when carved bamboo pegs were used to replace missing teeth in ancient China. The phenomenon of osseointegration, however, was not verified until the mid‐1960s, when Branemark discovered that titanium could integrate to bone. Since then, the osseointegration capacity of implants has been profoundly investigated and implants as such have evolved enormously in all possible aspects, from material selection and processing to specific surface engineering, among many others. This review article, in particular, focuses on dental implants and aims to introduce the main concerns involved in modern dentistry, concentrating especially on the importance of finding an effective way to prevent peri‐implantitis. In this sense, strategies such as shifting from metal to ceramic implant components and applying novel antimicrobial antibiotic‐free coatings seem to be taking the lead. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.

show abstract

“…As a result, the mean pore size within a scaffold affects cell adhesion and ensuing proliferation, migration, and infiltration [27]. A number of 3D porous scaffolds fabricated from synthetic or naturally derived biodegradable polymers have been developed and used for liver, bladder, nerve, skin, bone, cartilage, and ligament tissue engineering, and more recently, regenerative dentistry [28,29]. …”

Section: Introductionmentioning

confidence: 99%

Advances in the design of macroporous polymer scaffolds for potential applications in dentistry

Bencherif

Braschler

Renaud

2013

J Periodontal Implant Sci

109

View full text Add to dashboard Cite

A paradigm shift is taking place in medicine and dentistry from using synthetic implants and tissue grafts to a tissue engineering approach that uses degradable porous three-dimensional (3D) material hydrogels integrated with cells and bioactive factors to regenerate tissues such as dental bone and other oral tissues. Hydrogels have been established as a biomaterial of choice for many years, as they offer diverse properties that make them ideal in regenerative medicine, including dental applications. Being highly biocompatible and similar to native extracellular matrix, hydrogels have emerged as ideal candidates in the design of 3D scaffolds for tissue regeneration and drug delivery applications. However, precise control over hydrogel properties, such as porosity, pore size, and pore interconnectivity, remains a challenge. Traditional techniques for creating conventional crosslinked polymers have demonstrated limited success in the formation of hydrogels with large pore size, thus limiting cellular infiltration, tissue ingrowth, vascularization, and matrix mineralization (in the case of bone) of tissue-engineered constructs. Emerging technologies have demonstrated the ability to control microarchitectural features in hydrogels such as the creation of large pore size, porosity, and pore interconnectivity, thus allowing the creation of engineered hydrogel scaffolds with a structure and function closely mimicking native tissues. In this review, we explore the various technologies available for the preparation of macroporous scaffolds and their potential applications.

show abstract

Degradable polymers may improve dental practice

Cited by 31 publications

References 94 publications

A chitosan‐hyaluronic acid hydrogel scaffold for periodontal tissue engineering

A chitosan‐hyaluronic acid hydrogel scaffold for periodontal tissue engineering

Current state‐of‐the‐art and future perspectives of the three main modern implant‐dentistry concerns: Aesthetic requirements, mechanical properties, and peri‐implantitis prevention

Advances in the design of macroporous polymer scaffolds for potential applications in dentistry

Contact Info

Product

Resources

About