Degradable porous carboxymethyl chitin hemostatic microspheres

Li, Jiazhen; Leng, Fan; Lv, Shanshan; Huang, Wei; Sun, Weiqing; Jiang, Xulin

doi:10.1080/09205063.2020.1760461

Cited by 20 publications

(5 citation statements)

References 33 publications

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“…Also, chitosan has shown the ability to connect, stick, and multiply cells properly. In addition, it has been shown in studies that chitin and its derivatives show antibacterial and analgesic properties that stimulate tissue regeneration and accelerate wound healing ( Singh et al, 2017c ; Zhao et al, 2020 ). Hence, chitin and chitosan in different forms (such as films, hydrogels, and fibers) have been used as suitable candidates for wound dressing applications ( Naseri-Nosar and Ziora, 2018 ; Elangwe et al, 2023 ).…”

Section: Biomaterials Used In Wound Healingmentioning

confidence: 99%

A review of the current state of natural biomaterials in wound healing applications

Ansari,

Darvishi

2024

Front. Bioeng. Biotechnol.

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Skin, the largest biological organ, consists of three main parts: the epidermis, dermis, and subcutaneous tissue. Wounds are abnormal wounds in various forms, such as lacerations, burns, chronic wounds, diabetic wounds, acute wounds, and fractures. The wound healing process is dynamic, complex, and lengthy in four stages involving cells, macrophages, and growth factors. Wound dressing refers to a substance that covers the surface of a wound to prevent infection and secondary damage. Biomaterials applied in wound management have advanced significantly. Natural biomaterials are increasingly used due to their advantages including biomimicry of ECM, convenient accessibility, and involvement in native wound healing. However, there are still limitations such as low mechanical properties and expensive extraction methods. Therefore, their combination with synthetic biomaterials and/or adding bioactive agents has become an option for researchers in this field. In the present study, the stages of natural wound healing and the effect of biomaterials on its direction, type, and level will be investigated. Then, different types of polysaccharides and proteins were selected as desirable natural biomaterials, polymers as synthetic biomaterials with variable and suitable properties, and bioactive agents as effective additives. In the following, the structure of selected biomaterials, their extraction and production methods, their participation in wound healing, and quality control techniques of biomaterials-based wound dressings will be discussed.

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Section: Biomaterials Used In Wound Healingmentioning

confidence: 99%

A review of the current state of natural biomaterials in wound healing applications

Ansari,

Darvishi

2024

Front. Bioeng. Biotechnol.

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“…However, the traditional hemostatic materials such as bandages, gels, sponges, adhesives, and powders are all simple in function ( Fan et al, 2021 ; He et al, 2021 ; Meng et al, 2021 ; Wang et al, 2021 ), and may even cause secondary damage to the wound ( Kumar et al, 2019 ). Hemostatic hydrogel microsphere has the advantages of good biocompatibility ( Annamalai et al, 2018 ; Bian et al, 2021 ; Zhao et al (2020) , slow-release property ( Luo et al, 2018 ), and small size ( Sheikhi et al, 2019 ). In addition, it can act as an excellent microcarrier for hemostatic repairing, which has aroused the interest of researchers.…”

Section: Hydrogel Microsphere For Skin Repairmentioning

confidence: 99%

Preparation strategy of hydrogel microsphere and its application in skin repair

Chi¹,

Qiu²,

Ye³

et al. 2023

Front. Bioeng. Biotechnol.

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In recent years, hydrogel microsphere has attracted much attention due to its great potential in the field of skin repair. This paper reviewed the recent progress in the preparation strategy of hydrogel microsphere and its application in skin repair. In this review, several preparation methods of hydrogel microsphere were summarized in detail. In addition, the related research progress of hydrogel microspheres for skin repair was reviewed, and focused on the application of bioactive microspheres, antibacterial microspheres, hemostatic microspheres, and hydrogel microspheres as delivery platforms (hydrogel microspheres as a microcarrier of drugs, bioactive factors, or cells) in the field of skin repair. Finally, the limitations and future prospects of the development of hydrogel microspheres and its application in the field of skin repair were presented. It is hoped that this review can provide a valuable reference for the development of the preparation strategy of hydrogel microspheres and promote the application of hydrogel microspheres in skin repair.

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“…Porous hemostatic materials achieve hemostasis by absorbing blood and concentrating coagulation factors (e.g., zeolite-based hemostatic powders) [ 20 ]. Polysaccharide-based hemostatic materials achieve hemostasis via the adsorption and activation of blood cells through their electrical charge (e.g., chitosan) [ 21 , 22 , 23 ]. Natural inorganic-based hemostatic materials can achieve hemostasis by activating the coagulation pathway (e.g., kaolin) [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Highly Efficient Hemostatic Cross-Linked Polyacrylate Polymer Dressings for Immediate Hemostasis

Ye,

Yang,

Hao

et al. 2024

Polymers

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A traumatic hemorrhage is fatal due to the great loss of blood in a short period of time; however, there are a few biomaterials that can stop the bleeding quickly due to the limited water absorption speed. Here, a highly absorbent polymer (HPA), polyacrylate, was prepared as it has the best structure–effectiveness relationship. Within a very short period of time (2 min), HPA continually absorbed water until it swelled up to its 600 times its weight; more importantly, the porous structure comprised the swollen dressing. This instantaneous swelling immediately led to rapid hemostasis in irregular wounds. We optimized the HPA preparation process to obtain a rapidly water-absorbent polymer (i.e., HPA-5). HPA-5 showed favorable adhesion and biocompatibility in vitro. A rat femoral arteriovenous complete shear model and a tail arteriovenous injury model were established. HPA exhibited excellent hemostatic capability with little blood loss and short hemostatic time compared with CeloxTM in both of the models. The hemostatic mechanisms of HPA consist of fast clotting by aggregating blood cells, activating platelets, and accelerating the coagulation pathway via water absorption and electrostatic interaction. HPA is a promising highly water-absorbent hemostatic dressing for rapid and extensive blood clotting after vessel injury.

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Degradable porous carboxymethyl chitin hemostatic microspheres

Cited by 20 publications

References 33 publications

A review of the current state of natural biomaterials in wound healing applications

A review of the current state of natural biomaterials in wound healing applications

Preparation strategy of hydrogel microsphere and its application in skin repair

Highly Efficient Hemostatic Cross-Linked Polyacrylate Polymer Dressings for Immediate Hemostasis

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