Degradable self-adhesive epidermal sensors prepared from conductive nanocomposite hydrogel

Shao, Zhiang; Hu, Xiangming; Cheng, Weimin; Zhao, Yanyun; Hou, Jiaoyun; Wu, Mingyue; Xue, Di; Wang, Yuhao

doi:10.1039/d0nr04666c

Cited by 47 publications

(32 citation statements)

References 57 publications

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“…Mussel, a classic example of wet surface adhesion in nature, achieves excellent adhesion by secreting special adhesive proteins containing high levels of catechol amino acid ( Yu et al, 2020 ). Several investigations have demonstrated that polydopamines, the mussel-inspired biomaterials with good biocompatibility and biodegradability ( Li et al, 2020 ), exhibited excellent adhesion properties on almost any surface ( Suneetha et al, 2019 ; Shao et al, 2020 ). For example, Jia et al reported on the use of polydopamine microcapsules in prolonging the retention time of pesticides on leaves ( Jia et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Mussel-Inspired Microgel Encapsulated NLRP3 Inhibitor as a Synergistic Strategy Against Dry Eye

Zha

Chen

Xiao

et al. 2022

Front. Bioeng. Biotechnol.

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The inflammatory response mediated by oxidative stress is the main pathogenesis of dry eye, but clinical observations have shown that scavenging oxygen-free radicals alone has limited therapeutic effect. Moreover, the unique anatomy and physiology of the ocular surface result in low bioavailability of drugs, and higher concentration is required to achieve the desired efficacy, which, however, may bring systemic side effects. These problems pose a challenge, but the revelation of the ROS-NLRP3-IL-1β signaling axis opens up new possibilities. In this investigation, an NLRP3 inhibitor was successfully encapsulated in polydopamine-based microgels and used for dry eye treatment. It was demonstrated that the well-designed microgels exhibited good biocompatibility, prolonged drug retention time on the ocular surface, and effective inhibition of corneal epithelial damage and cell apoptosis. In addition, due to the synergistic effect, the NLRP3 inhibitor–loaded microgels could exert enhanced oxygen radical scavenging and inflammation-inhibiting effects at a lower dose than monotherapy. These findings suggest that polydopamine-based microgels have advantages as ocular surface drug delivery platforms and have promising applications in oxidative damage–related inflammatory diseases in synergy with anti-inflammatory drugs.

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Section: Introductionmentioning

confidence: 99%

Mussel-Inspired Microgel Encapsulated NLRP3 Inhibitor as a Synergistic Strategy Against Dry Eye

Zha

Chen

Xiao

et al. 2022

Front. Bioeng. Biotechnol.

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“…The volume resistivity (r) of the conductive path was measured by a four-probe method and calibrated using formula (2). As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Additive manufacturing technology has attracted increasing attention towards printed circuit boards (PCBs) and integrated circuits (ICs) because it provides enormous potential and opportunities for the production of diverse electronic devices such as multi-axial sensors, wearable electronic equipments and e-skins for robotics applications. [1][2][3] The conventional subtractive manufacturing has many drawbacks including complex process, long production cycle, and serious environmental pollution. 4,5 Inkjet printing or screen printing served as low cost, simple implementation and environmentally friendly technologies that can be utilized directly for conductive patterns.…”

Section: Introductionmentioning

confidence: 99%

Facile fabrication and low-temperature bonding of Cu@Sn–Bi core–shell particles for conductive pastes

et al. 2021

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“…To prepare the sensorized gelatin hydrogel (SGH), aqueous carbon black (CB) is added to the mix and allowed to homogenise. The addition of conductive elements to hydrogels and specific gelatin-based hydrogels has been explored previously [26], [27], [28], and is a widely used approach for developing inorganic strain and pressure sensors [29], [30], [31].…”

Section: A Hydrogel Preparationmentioning

confidence: 99%

3D Printable Sensorized Soft Gelatin Hydrogel for Multi-Material Soft Structures

Hardman

Hughes

Thuruthel

et al. 2021

IEEE Robot. Autom. Lett.

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The ability to 3D print soft materials with integrated strain sensors enables significant flexibility for the design and fabrication of soft robots. Hydrogels provide an interesting alternative to traditional soft robot materials, allowing for more varied fabrication techniques. In this work, we investigate the 3D printing of a gelatin-glycerol hydrogel, where transglutaminase is used to catalyse the crosslinking of the hydrogel such that its material properties can be controlled for 3D printing. By including electron-conductive elements (aqueous carbon black) in the hydrogel we can create highly flexible and linear soft strain sensors. We present a first investigation into adapting a desktop 3D printer and optimizing its control parameters to fabricate sensorized 2D and 3D structures which can undergo >300% strain and show a response to strain which is highly linear and synchronous. To demonstrate the capabilities of this material and fabrication approach, we produce some example 2D and 3D structures and show their sensing capabilities.

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Degradable self-adhesive epidermal sensors prepared from conductive nanocomposite hydrogel

Abstract: Conductive hydrogels based epidermal sensors are attracting enormous interest due to their great potential in soft robotics, electronic skins, bioelectronics and personalized healthcare monitoring. However, the conventional conductive hydrogels based...

Cited by 47 publications

References 57 publications

Mussel-Inspired Microgel Encapsulated NLRP3 Inhibitor as a Synergistic Strategy Against Dry Eye

Mussel-Inspired Microgel Encapsulated NLRP3 Inhibitor as a Synergistic Strategy Against Dry Eye

Facile fabrication and low-temperature bonding of Cu@Sn–Bi core–shell particles for conductive pastes

3D Printable Sensorized Soft Gelatin Hydrogel for Multi-Material Soft Structures

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