Degradation and biocompatibility of a series of strontium substituted hydroxyapatite coatings on magnesium alloys

Gu, Xuenan; Lin, Wenting; Li, Dan; Guo, Hongmei; Li, Ping; Fan, Yubo

doi:10.1039/c9ra02210d

Cited by 23 publications

(12 citation statements)

References 43 publications

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“…Furthermore, many ceramics are less bioresorbable than the polymers used in BTE, which could be detrimental to new bone ingrowth [ 83 ]. Due to this, researchers have resorted to the manipulation of slowly degrading ceramics, particularly HA, by structure destabilization (through the addition of ions) in order to accelerate degradation [ 84 ]. Table 2 provides a short list of ceramics that have been used for BTE applications along with their inherent strengths and weaknesses.…”

Section: Bone Tissue Engineering: Cells Materials and Cuesmentioning

confidence: 99%

Conductive Scaffolds for Bone Tissue Engineering: Current State and Future Outlook

Dixon

Gomillion

2021

JFB

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Bone tissue engineering strategies attempt to regenerate bone tissue lost due to injury or disease. Three-dimensional (3D) scaffolds maintain structural integrity and provide support, while improving tissue regeneration through amplified cellular responses between implanted materials and native tissues. Through this, scaffolds that show great osteoinductive abilities as well as desirable mechanical properties have been studied. Recently, scaffolding for engineered bone-like tissues have evolved with the use of conductive materials for increased scaffold bioactivity. These materials make use of several characteristics that have been shown to be useful in tissue engineering applications and combine them in the hope of improved cellular responses through stimulation (i.e., mechanical or electrical). With the addition of conductive materials, these bioactive synthetic bone substitutes could result in improved regeneration outcomes by reducing current factors limiting the effectiveness of existing scaffolding materials. This review seeks to overview the challenges associated with the current state of bone tissue engineering, the need to produce new grafting substitutes, and the promising future that conductive materials present towards alleviating the issues associated with bone repair and regeneration.

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Section: Bone Tissue Engineering: Cells Materials and Cuesmentioning

confidence: 99%

Conductive Scaffolds for Bone Tissue Engineering: Current State and Future Outlook

Dixon

Gomillion

2021

JFB

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“…According to the literature, the incorporation of Sr into the HAp structure is not limited. Namely, it is possible to replace Ca (ionic radius 0.099 nm) with Sr (ionic radius 0.113 nm) in the full spectrum from 0 to 100%, maintaining the purity of the HAp phase. − However, the substitution of Ca by Sr in HAp is not thermodynamically favorable, and the substitution degree depends mainly on the initial Sr concentration in the synthesis solution. , It has been reported that HAp has a high affinity toward both positively and negatively charged molecules . We assume that the highly charged nature of HAp determines its electrostatic binding affinity to SrRAN molecules.…”

Section: Resultsmentioning

confidence: 99%

A Comparative Study on Physicochemical Properties and In Vitro Biocompatibility of Sr-Substituted and Sr Ranelate-Loaded Hydroxyapatite Nanoparticles

Stipniece,

Ramata-Stunda,

Vecstaudza

et al. 2023

ACS Appl. Bio Mater.

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Synthetic hydroxyapatite nanoparticles (nHAp) possess compositional and structural similarities to those of bone minerals and play a key role in bone regenerative medicine. Functionalization of calcium phosphate biomaterials with Sr, i . e ., bone extracellular matrix trace element, has been proven to be an effective biomaterial-based strategy for promoting osteogenesis in vitro and in vivo . Functionalizing nHAp with Sr 2+ ions or strontium ranelate (SrRAN) can provide favorable bone tissue regeneration by locally delivering bioactive molecules to the bone defect microenvironment. Moreover, administering an antiosteoporotic drug, SrRAN, directly into site-specific bone defects could significantly reduce the necessary drug dosage and the risk of possible side effects. Our study evaluated the impact of the Sr source (Sr 2+ ions and SrRAN) used to functionalize nHAp by wet precipitation on its in vitro cellular activities. The systematic comparison of physicochemical properties, in vitro Sr 2+ and Ca 2+ ion release, and their effect on in vitro cellular activities of the developed Sr-functionalized nHAp was performed. The ion release tests in TRIS-HCl demonstrated a 21-day slow and continuous release of the Sr 2+ and Ca 2+ ions from both Sr-substituted nHAp and SrRAN-loaded HAp. Also, SrRAN and Sr 2+ ion release kinetics were evaluated in DMEM to understand their correlation with in vitro cellular effects in the same time frame. Relatively low concentration (up to 2 wt %) of Sr in the nHAp led to an increase in the alkaline phosphatase activity in preosteoblasts and expression of collagen I and osteocalcin in osteoblasts, demonstrating their ability to boost bone formation.

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“…In recent years, magnesium alloys have received extensive attention due to their similar elastic modulus to that of human bone, excellent bioactivity, degradability, and osteoinductivity [1][2][3][4]. Unfortunately, the corrosion resistance of magnesium alloys is poor and the corrosion rate in the body fluid is rapid, which may result in a large amount of hydrogen production and intense alkalization of surrounding tissues, and thus greatly limit their application in the medical field.…”

Section: Introductionmentioning

confidence: 99%

Electrodeposition of micro-nano hierarchically structured fluoridated hydroxyapatite coating on AZ31B alloy

Wang

Sun

et al. 2020

Surface Engineering

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In this study, a novel micro-nano hierarchically structured fluoridated hydroxyapatite (FHAp) coating on AZ31B substrate was successfully synthesized via a simple one-step electrochemical deposition method. And the formulation of the electrodeposition solution is simple and environment-friendly without any harmful additives. The FHAp coating consists of a large amount of nanorods and some micro-structured spherical aggregates composed of nanorods. Electrochemical tests demonstrated that the FHAp coating exhibited higher anti-corrosion property and lower degradation rate than that of pure HAp coating. Moreover, the FHAp coating with micro-nano hierarchically structured surface displayed good cell biocompatibility. The addition of fluorine ion into HAp coating can further promote the cell adhesion and proliferation. This work provides a simple, environment-friendly, and efficient way to prepare FHAp coating on AZ31B alloy with improved corrosion resistance and biocompatibility.

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Degradation and biocompatibility of a series of strontium substituted hydroxyapatite coatings on magnesium alloys

Abstract: Sr-HA coatings could simply improve the degradation and osteoblast response of Mg in a Sr-dose dependent manner.

Cited by 23 publications

References 43 publications

Conductive Scaffolds for Bone Tissue Engineering: Current State and Future Outlook

Conductive Scaffolds for Bone Tissue Engineering: Current State and Future Outlook

A Comparative Study on Physicochemical Properties and In Vitro Biocompatibility of Sr-Substituted and Sr Ranelate-Loaded Hydroxyapatite Nanoparticles

Electrodeposition of micro-nano hierarchically structured fluoridated hydroxyapatite coating on AZ31B alloy

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