Degradation and metabolism of <sup>14</sup>C‐labelled proanthocyanidins from carob (<i>Ceratonia siliqua</i>) pods in the gastrointestinal tract of the rat

Abia, Rocı́o; Fry, Stephen C.

doi:10.1002/jsfa.924

Cited by 41 publications

(20 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, Terrill, Waghorn, Woolley, McNabb, and Barry (1994) showed that polymeric CT are poorly recovered after their transit though the rumen. However, Makkar, Becker, Abel, and Szegletti (1995) demonstrated that rumen microorganisms do not hydrolyse CT. Conversely, studies in rats and humans indicated that CT are not inert within the gut, but undergo structural modifications operated by the intestinal microflora (Abia & Fry, 2001;Déprez et al, 2000). Nevertheless, the effect of dietary CT on meat oxidative stability may be indirect, through the interaction between CT with other antioxidants compounds or with pro-oxidants compounds present in meat.…”

Section: Meat Lipid Oxidationmentioning

confidence: 96%

Effect of dietary grape seed extract and Cistus ladanifer L. in combination with vegetable oil supplementation on lamb meat quality

Jerónimo

Alfaia²,

Alves

et al. 2012

Meat Science

View full text Add to dashboard Cite

Section: Meat Lipid Oxidationmentioning

confidence: 96%

Effect of dietary grape seed extract and Cistus ladanifer L. in combination with vegetable oil supplementation on lamb meat quality

Jerónimo

Alfaia²,

Alves

et al. 2012

Meat Science

View full text Add to dashboard Cite

“…This may also contribute to the lower number of metabolites and to the lower extent of metabolism of long-chain condensed catechins. In contrast, the low degree of polymerization of condensed catechins supports their degradation, especially in the caecum, resulting in an accumulation of polar phenolic compounds (Abia and Fry 2001;Levrat et al 1993).…”

Section: Transformation Of Condensed Catechins By Colonic Microbiotamentioning

confidence: 96%

Microbial metabolism of dietary phenolic compounds in the colon

2008

View full text Add to dashboard Cite

Plant foods contain substantial amounts of phenolic compounds. Dietary interventions with phenolic supplementation show that phenolic compounds are transformed into phenolic acids or lactone structures by intestinal microbiota. The colon is the main site of microbial fermentation. The metabolites circulate in plasma and are excreted via urine. The entero-hepatic circulation ensures that their residence time in plasma is extended compared to that of their parent compounds. Thus these metabolites may exert systemic effects, which however have not been studied adequately. In particular the health implications of microbial metabolites of flavonoids, mostly phenolic acids, are unknown. This review aims to elucidate the microbial metabolism of most of the phenolic classes: flavonoids, isoflavonoids, lignans, phenolic acids and tannins. Some examples of biological activity studies of flavonoid and lignan metabolites are given. Biological significance of enterolactone, a mammalian plant lignan metabolite, has been studied quite extensively, but convincing evidence of the health benefits of the diverse pool of microbial metabolites is still scarce. Hopefully, novel tools in systems biology and the constant search for biomarkers will elucidate the role of the phenolic metabolome in health and in the prevention of chronic diseases. In conclusion, the colon is not only an excretion route, but also an active site of metabolism and deserves further attention from the scientific community.

show abstract

“…In vivo, hydrolysis of procyanidins B2 and B5 to epicatechin has been reported in isolated rat small intestine [128]. The degree of polymerisation of proanthocyanidins has also been reported to decrease in rat small intestine [129]. Nevertheless, other in vivo findings suggest that oligomeric proanthocyanidins are not depolymerised into monomeric flavan-3-ols to any extent during passage through the stomach and gastrointestinal tract in rats, although trace quantities of procyanidin B1, B2, B3 and B4 dimers and the C2 trimer have been detected in urine [124].…”

Section: Gastric and Small Intestine Metabolism And Absorptionmentioning

confidence: 97%

Tannins: Current knowledge of food sources, intake, bioavailability and biological effects

Serrano

Puupponen‐Pimiä

Dauer

et al. 2009

Molecular Nutrition Food Res

671

511

View full text Add to dashboard Cite

Tannins are a unique group of phenolic metabolites with molecular weights between 500 and 30 000 Da, which are widely distributed in almost all plant foods and beverages. Proanthocyanidins and hydrolysable tannins are the two major groups of these bioactive compounds, but complex tannins containing structural elements of both groups and specific tannins in marine brown algae have also been described. Most literature data on food tannins refer only to oligomeric compounds that are extracted with aqueous‐organic solvents, but a significant number of non‐extractable tannins are usually not mentioned in the literature. The biological effects of tannins usually depend on their grade of polymerisation and solubility. Highly polymerised tannins exhibit low bioaccessibility in the small intestine and low fermentability by colonic microflora. This review summarises a new approach to analysis of extractable and non‐extractable tannins, major food sources, and effects of storage and processing on tannin content and bioavailability. Biological properties such as antioxidant, antimicrobial and antiviral effects are also described. In addition, the role of tannins in diabetes mellitus has been discussed.

show abstract

Degradation and metabolism of ¹⁴C‐labelled proanthocyanidins from carob (Ceratonia siliqua) pods in the gastrointestinal tract of the rat

Abstract: The aim of the work was to study the binding, degradation and metabolism of dietary condensed tannins in the gastrointestinal tract of an omnivore. Young pods of carob (Ceratonia siliqua L) were radiolabelled by in vivo feeding of 14

Cited by 41 publications

References 48 publications

Effect of dietary grape seed extract and Cistus ladanifer L. in combination with vegetable oil supplementation on lamb meat quality

Effect of dietary grape seed extract and Cistus ladanifer L. in combination with vegetable oil supplementation on lamb meat quality

Microbial metabolism of dietary phenolic compounds in the colon

Tannins: Current knowledge of food sources, intake, bioavailability and biological effects

Contact Info

Product

Resources

About

Degradation and metabolism of 14C‐labelled proanthocyanidins from carob (Ceratonia siliqua) pods in the gastrointestinal tract of the rat

Abstract: The aim of the work was to study the binding, degradation and metabolism of dietary condensed tannins in the gastrointestinal tract of an omnivore. Young pods of carob (Ceratonia siliqua L) were radiolabelled by in vivo feeding of 14

Cited by 41 publications

References 48 publications

Effect of dietary grape seed extract and Cistus ladanifer L. in combination with vegetable oil supplementation on lamb meat quality

Effect of dietary grape seed extract and Cistus ladanifer L. in combination with vegetable oil supplementation on lamb meat quality

Microbial metabolism of dietary phenolic compounds in the colon

Tannins: Current knowledge of food sources, intake, bioavailability and biological effects

Contact Info

Product

Resources

About

Degradation and metabolism of ¹⁴C‐labelled proanthocyanidins from carob (Ceratonia siliqua) pods in the gastrointestinal tract of the rat