Degradation and residues of indoxacarb enantiomers in rice plants, rice hulls and brown rice using enriched <i>S‐</i>indoxacarb formulation and enantiopure formulation

Shi, Lihong; Gui, Ting; Zhao, S. J.; Wang, Fei; Sui, Changling; Zhang, Yuping; Hu, Deyu

doi:10.1002/bmc.4301

Cited by 13 publications

(9 citation statements)

References 28 publications

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“…Indoxacarb can impair nerve function and cause loss of appetite, paralysis, or death of target pests such as lepidoptera, some homoptera, and coleoptera pests by blocking the sodium channel of the target neuron (Lapied et al 2001;Li et al 2018). Because of its insecticidal activity, indoxacarb is used for pest control in rice (Shi et al 2018), tea (Zhang et al 2014a(Zhang et al , 2015, fruits, vegetables, soybeans, alfalfa, peanuts, and other crops (Sun et al 2013); it is now registered and listed in more than 75 countries around the world, with global sales reaching $185 million in 2014 (Hua 2019). The average concentration of indoxacarb in surface water ranges from 3.7 to 7.8 μg/L, and the peak concentration is 13.7 μg/L (European Food Safety Authority et al 2018; Monteiro et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Enantioselective Bioaccumulation of the Chiral Insecticide Indoxacarb in Zebrafish (Danio rerio)

Liang

Qiu

2021

Enviro Toxic and Chemistry

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Indoxacarb is a typical chiral insecticide widely used in agricultural pest control. In the present study, zebrafish was used as a model animal to explore the enantioselective bioaccumulation behavior of indoxacarb to nontarget species in aquatic environments. Zebrafish were exposed to 0.025 and 0.1 mg/L rac-indoxacarb solution for 12 d under the semistatic method, and the bioconcentration factor (BCF) and enantiomeric fraction of zebrafish were investigated. The results showed that the (−)-R-indoxacarb preferentially accumulated in zebrafish. The BCF values at 0.025 mg/L exposure levels were 1079.8 and 83.4 L/kg for (−)-R-indoxacarb and (+)-S-indoxacarb after 12 d, respectively. The BCF values at 0.1 mg/L exposure levels were 1752.1 and 137.0 L/kg for (−)-R-indoxacarb and (+)-S-indoxacarb after 10 d, respectively. The half-life values of (−)-Rindoxacarb and (+)-S-indoxacarb were 3.47 and 2.05 d for 0.025 mg/L concentration exposure and 4.95 and 2.66 d for 0.1 mg/L concentration exposure, respectively. The enantiomeric fraction values were in the range of 0.48 to 0.55 and 0.89 to 1.00 for water and zebrafish samples, respectively. Studies on the enantioselective bioaccumulation behavior of indoxacarb will provide data for assessing the environmental fate and potential toxic effects of indoxacarb on aquatic organisms.

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Section: Introductionmentioning

confidence: 99%

Enantioselective Bioaccumulation of the Chiral Insecticide Indoxacarb in Zebrafish (Danio rerio)

Liang

Qiu

2021

Enviro Toxic and Chemistry

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“…The polysaccharide-derived CSP has been demonstrated to have a high potential for rapid chiral separation, with the two enantiomers of indoxacarb achieving baseline separation on Chiralpak AS-H, Superchiral S-OD and Chiralcel IG-3 chiral columns. [30][31][32] However, reports on the separation of DCJW on any chiral CSP do not exist. In this study, we used five polysaccharide-based CSPs (Superchiral S-OD, Chiralpak IH-3, Chiralpak IC, Chiralpak IB and Chiralpak IA) to separate the enantiomers of indoxacarb and DCJW under reversed-phase conditions.…”

Section: Development Of Methods For Quantitative Analysis 331 Chiral ...mentioning

confidence: 99%

Enantioselectivity of indoxacarb enantiomers in Bombyx mori larvae: toxicity, bioaccumulation and biotransformation

Lin

Deng

Tang

et al. 2023

Pest Management Science

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Background Indoxacarb is a chiral insecticide with excellent insecticidal activity against lepidopterous insects. Because of their enantioselectivity, chiral pesticides' environmental behavior at the enantiomeric level has been highlighted. The chiral stability, enantioselective bioaccumulation, biotransformation behavior of indoxacarb to a non‐target insect silkworm are still unclear. Results A chiral analysis method for indoxacarb and its metabolite DCJW in silkworm was developed using liquid chromatography and high‐resolution mass spectrometry (HPLC/HRMS). In silkworms, the recoveries of indoxacarb and DCJW were 86.06%‐104.52% with relative standard deviation (RSD) < 9.01%. The 96‐h lethal concentration (LC50) values of R‐indoxacarb, S‐indoxacarb, and enriched S‐indoxacarb (2.333 S/1R) were 1.08 × 102, 1.92, and 6.89 mg a.i. L−1, respectively, according to the acute toxicity test results. When silkworm larvae were exposed to 1/50 of the LC50 concentration, the bioconcentration factor (BCF) of R‐indoxacarb was 0.0296–0.318, and the BCF of S‐indoxacarb was 0.0125–0.211. In silkworm larvae, the amount of R‐DCJW produced by R‐indoxacarb was 0.00610 to 2.34 times that of the parent R‐indoxacarb, and the amount of S‐DCJW produced by S‐indoxacarb was 0.125–36.9 times that of the parent S‐indoxacarb. Conclusion There was no chiral transition from S‐indoxacarb to R‐indoxacarb or a transformation from R‐indoxacarb to S‐indoxacarb. Indoxacarb was preferentially bioaccumulated in silkworm larva, while S‐indoxacarb bioconversion into the metabolite S‐DCJW was much greater than R‐indoxacarb bioconversion into R‐DCJW. This study could improve understanding of the indoxacarb accumulation and transformation process in insects, as well as provide more scientific data for indoxacarb environmental and ecological risk assessment. © 2023 Society of Chemical Industry.

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“…The dissipation study on indoxacarb in rice [14] found that the half-lives of R-indoxacarb and S-indoxacarb were 4.20-4.33 and 3.45-3.57 d in rice straw. In this study, the half-lives of indoxacarb in rice husk and brown rice were 4.4-8.1 and 10.3-20.4 d, respectively, which inferred that indoxacarb dissipated faster in rice straw than in husk and brown rice.…”

Section: Residue Dissipation Studymentioning

confidence: 99%

“…The QuEChERS method was employed to determine indoxacarb in rice-related matrices by LC-MS/MS, in which the rice samples were cleaned up by N-propyl ethylene diamine (PSA) and Octadecylsilyl, ODS (C18), while the soil samples were not purified [13]. Besides, the degradation and residues of indoxacarb enantiomers were determined in rice using chiral liquid chromatography-tandem high-resolution mass spectrometry [14].…”

Section: Introductionmentioning

confidence: 99%

Dissipation, Residue Analysis, and Dietary Risk Assessment of Chlorantraniliprole and Indoxacarb in Rice

Zhou

Han

et al. 2023

Food Science and Engineering

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A residue analytical method for the determination of chlorantraniliprole and indoxacarb in brown rice, rice husk, and rice straw was validated using a revised QuEChERS method coupled with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), and field trials were conducted in 12 regions to study the dissipation and final residues of the two pesticides in rice crop. In the method validation, chlorantraniliprole and indoxacarb had average recoveries ranging from 79% to 110%, with relative standard deviations (RSD) of 1.2% to 12.2%. The dissipation experiments showed that the half-lives of chlorantraniliprole in brown rice and rice husk were 12.4-29.8 and 4.6-11.2 d, respectively, whereas the dissipation half-lives of indoxacarb were 10.3-20.4 and 4.4-8.1 d, respectively. As for the final residues in the 12 regions, rice samples were collected on the 28 and 35 d after the last application. The maximum residues of chlorantraniliprole and indoxacarb in rice grain were 0.38 mg/kg and 0.080 mg/kg, respectively, and in brown rice, the maximum residues of chlorantraniliprole and indoxacarb were 0.028 mg/kg and 0.040 mg/kg, respectively. These values were all below the relevant Maximum Residue Limits (MRLs) in China. Using the final residue results and the food consumption data, the long-term dietary risk assessment indicated that the residues of these two pesticides in rice would not pose unacceptable dietary risk to the general population.

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Degradation and residues of indoxacarb enantiomers in rice plants, rice hulls and brown rice using enriched S‐indoxacarb formulation and enantiopure formulation

Cited by 13 publications

References 28 publications

Enantioselective Bioaccumulation of the Chiral Insecticide Indoxacarb in Zebrafish (Danio rerio)

Enantioselective Bioaccumulation of the Chiral Insecticide Indoxacarb in Zebrafish (Danio rerio)

Enantioselectivity of indoxacarb enantiomers in Bombyx mori larvae: toxicity, bioaccumulation and biotransformation

Dissipation, Residue Analysis, and Dietary Risk Assessment of Chlorantraniliprole and Indoxacarb in Rice

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