Degradation characteristics of hydroxyapatite coatings on orthopaedic TiAlV in simulated physiological media investigated by electrochemical impedance spectroscopy

Laz, M. Milagros; Reis, Rui L.

doi:10.1016/s0142-9612(03)00362-4

Cited by 170 publications

(91 citation statements)

References 32 publications

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“…However, the alterations introduced in this layer during the coating process can affect corrosion resistance, which is one of the main factors that renders titanium an excellent biomaterial [14][15][16][17]. Thus, physical properties of the coating, such as size, morphology, present phases, crystallinity, and thickness, must be evaluated.…”

Section: Introductionmentioning

confidence: 99%

Corrosion behavior of pure titanium in artificial saliva solution

et al. 2009

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The biocompatibility of commercially pure (cp) titanium stems from its chemical stability within an organism, due to a fine film of impermeable titanium oxide covering the metal surface, which guarantees its resistance to corrosion. Despite its biocompatible characteristic, this material does not promote the formation of a hydroxyapatite layer, therefore, many research groups have sought to alter the material's surface, introducing modifications that might influence corrosion resistance. The electrochemical behavior of cp Ti, with hydroxyapatite coating and without hydroxyapatite coating, commonly used in implant materials, was investigated using an artificial saliva solution at 25 o C and pH=7.4. In the conditions of the study it was observed that the hydroxyapatite layer influences the properties of corrosion resistance. This study of the behavior of cp Ti with and without hydroxyapatite coating, in naturally aerated artificial saliva solution at 25 o C, was based on open circuit potential measurements and potentiodynamic polarization curves. At approximately 1x10 -6 A/cm 2 the potential for cp Ti with and without hydroxyapatite coating begins to increase at a faster rate, but at -74mV (SCE) for coated cp Ti and at 180mV (SCE) for uncoated cp Ti the increase in potential begins to slow. This behavior, characterized by a partial stabilization of current density, indicates that in those potential ranges a protective passive film is formed.

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Section: Introductionmentioning

confidence: 99%

Corrosion behavior of pure titanium in artificial saliva solution

et al. 2009

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“…In general, the degradation of HA is a long-term process in a physiological environment without involvement of osteoclasts and macrophages. [43][44] The quick HA biodegradation in the BMP2-loaded microsphere group suggests an early bone remodeling process involving the participation of both osteoclasts and osteoblasts. Based on the data in Figures 5 and 6, a general equilibrium between bone formation and resorption appears to be established between 4 and 8 weeks in this group, and HA microspheres disappear at about 12 weeks.…”

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confidence: 99%

BMP2-loaded hollow hydroxyapatite microspheres exhibit enhanced osteoinduction and osteogenicity in large bone defects

Xiong¹,

Zeng²,

Yao³

et al. 2015

IJN

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The regeneration of large bone defects is an osteoinductive, osteoconductive, and osteogenic process that often requires a bone graft for support. Limitations associated with naturally autogenic or allogenic bone grafts have demonstrated the need for synthetic substitutes. The present study investigates the feasibility of using novel hollow hydroxyapatite microspheres as an osteoconductive matrix and a carrier for controlled local delivery of bone morphogenetic protein 2 (BMP2), a potent osteogenic inducer of bone regeneration. Hollow hydroxyapatite microspheres (100±25 μm) with a core (60±18 μm) and a mesoporous shell (180±42 m 2 /g surface area) were prepared by a glass conversion technique and loaded with recombinant human BMP2 (1 μg/mg). There was a gentle burst release of BMP2 from microspheres into the surrounding phosphate-buffered saline in vitro within the initial 48 hours, and continued at a low rate for over 40 days. In comparison with hollow hydroxyapatite microspheres without BMP2 or soluble BMP2 without a carrier, BMP2-loaded hollow hydroxyapatite microspheres had a significantly enhanced capacity to reconstitute radial bone defects in rabbit, as shown by increased serum alkaline phosphatase; quick and complete new bone formation within 12 weeks; and great biomechanical flexural strength. These results indicate that BMP2-loaded hollow hydroxyapatite microspheres could be a potential new option for bone graft substitutes in bone regeneration.

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“…When the value of the exponent n 2 is approximately 1, then CPE2 can be said to behave similarly to a pure capacitor. The value of the exponent n 1 is lower than those of n 2 ; this may be due to higher defectiveness, heterogeneity, and roughness of the outer layer [13].…”

Section: Resultsmentioning

confidence: 85%

Chemical properties of hydroxyapatite deposited through electrophoretic process on different sandblasted samples

Gradinariu

Ştirbu

Gheorghe

et al. 2014

Materials Science-Poland

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An implantable material based on titanium (Ti6Al4V) was sandblasted in order to be deposited with a thin film of hydroxyapatite. Two samples of the alloy, in a shape of a bar with 10 mm diameter and 20 mm length, were subjected to mechanical treatment. After deposition of the hydroxyapatite through electrophoresis process, the samples were analyzed by scanning electron microscopy. The nature and chemical properties of thin films formed on Ti-based substrate were investigated with electrochemical impedance spectroscopy based on the extremely high polarization resistance of the material. The results revealed the formation of a homogeneous layer on the surface of the metallic substrate. The layer composed of TiO 2 and hydroxyapatite provided a high corrosion protection.

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Degradation characteristics of hydroxyapatite coatings on orthopaedic TiAlV in simulated physiological media investigated by electrochemical impedance spectroscopy

Cited by 170 publications

References 32 publications

Corrosion behavior of pure titanium in artificial saliva solution

Corrosion behavior of pure titanium in artificial saliva solution

BMP2-loaded hollow hydroxyapatite microspheres exhibit enhanced osteoinduction and osteogenicity in large bone defects

Chemical properties of hydroxyapatite deposited through electrophoretic process on different sandblasted samples

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Degradation characteristics of hydroxyapatite coatings on orthopaedic TiAlV in simulated physiological media investigated by electrochemical impedance spectroscopy

Cited by 170 publications

References 32 publications

Corrosion behavior of pure titanium in artificial saliva solution

Corrosion behavior of pure titanium in artificial saliva solution

BMP2-loaded hollow hydroxyapatite&nbsp;microspheres exhibit enhanced osteoinduction and osteogenicity in large bone defects

Chemical properties of hydroxyapatite deposited through electrophoretic process on different sandblasted samples

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BMP2-loaded hollow hydroxyapatite microspheres exhibit enhanced osteoinduction and osteogenicity in large bone defects