Degradation characteristics of α and β tri-calcium-phosphate (TCP) in minipigs

Wiltfang, Joörg; Merten, H. A.; Schlegel, K. A.; Schultze-Mosgau, S.; Kloss, Frank; Rupprecht, Stephan; Keßler, Peter

doi:10.1002/jbm.10084.abs

Cited by 29 publications

(39 citation statements)

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“…On the other hand, TCP possesses higher biodegradability than HAp in vivo 20) . The physical characteristics of -TCP result in higher and earlier remodeling activity compared with β-TCP 6) . Biopolymer scaffolds have often been combined with calcium phosphate as described above.…”

Section: Discussionmentioning

confidence: 99%

“…Hydroxyapatite (HAp), tricalcium phosphate (TCP) and tetracalcium phosphate have been widely used as substitutes for autologous bone in orthopedic and maxillofacial surgery, since these materials show high biocompatibility and osteocompatibility. Among the different calcium phosphate materials, previous studies have demonstrated a role for -TCP particles as bonerebuilding materials by gradual biodegradation and the formation of bone around them 5,6) . Such characteristics of -TCP particles would be suitable for bone graft materials.…”

Section: Introductionmentioning

confidence: 99%

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Effects on bone regeneration when collagen model polypeptides are combined with various sizes of alpha-tricalcium phosphate particles

et al. 2011

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We evaluated the effects on bone formation of combining synthesized collagen model polypeptides consisting of a Pro-Hyp-Gly [poly(PHG)] sequence and alpha-tricalcium phosphate (-TCP) particles with various median sizes (large: 580.8 µm; small: 136.2 µm; or large and small mixed: 499.3 µm) in a skull defect model in mini-pigs. Quantitative image analyses for the volume density (VD) of new bone revealed that the VD in each -TCP group was significantly higher than that in the poly(PHG) control group, with the mixed group showing the highest VD among all the groups at 4 weeks after implantation. Histological assessments revealed that the small -TCP particles were almost completely degraded at 8 weeks. At 12 weeks, all sizes of -TCP particles were completely degraded and remodeling of the lamellar bone was observed. The present findings suggest that particle size may influence the success of bone formation in defects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects on bone regeneration when collagen model polypeptides are combined with various sizes of alpha-tricalcium phosphate particles

et al. 2011

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“…Calcium phosphate implants show excellent resorption characteristics. Tricalcium phosphate (TCP, Ca 3 (PO 4 ) 2 ) has been developed as a bioactive and biodegradable bone substitute (Metsger et al, 1982;Wiltfang et al, 2002). Although the calcium phosphate implants are replaced by normal bone tissue, the loadbearing capacity is signifi cantly weakened during the remodeling process because the rate of biodegradation of TCP is too fast.…”

Section: Effects Of Processing Ceramics On Their Microstructuresmentioning

confidence: 99%

The microstructure of bioceramics and its analysis

Hayakawa

Tsuru

Osaka

2008

Bioceramics and Their Clinical Applications

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“…A few ceramics can degrade, for instance the group of calcium phosphates [14]. However, ceramics present the problem of high strength in combination with low ductility.…”

Section: Introductionmentioning

confidence: 99%

Development of Magnesium Alloy Scaffolds to Support Biological Myocardial Grafts: A Finite Element Investigation

Weidling

Besdo

Schilling

et al. 2014

Biomedical Technology

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Lesioned myocardial tissue can be replaced with innovative biological grafts. However, the strength of most biological grafts is initially not sufficient for left ventricular applications. Implants that mechanically support these grafts and gradually lose their function as the graft develops its strength are a possible solution. We are developing magnesium alloy scaffolds for this purpose. The finite element method was used to perform simulations wherein scaffolds are deformed according to the heart movement. This allows us to identify highly stressed regions within the implant that need design changes. Preformed scaffolds were determined to have significantly lower stresses in comparison to flat ones. The method of tensile triangles suggests shape changes for notable stress reduction. Furthermore, new scaffold shapes were developed and simulated. Two of them are recommended for further examinations through in vitro and in vivo tests. A completely new alternative scaffold concept is also proposed.

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Degradation characteristics of α and β tri-calcium-phosphate (TCP) in minipigs

Cited by 29 publications

References 0 publications

Effects on bone regeneration when collagen model polypeptides are combined with various sizes of alpha-tricalcium phosphate particles

Effects on bone regeneration when collagen model polypeptides are combined with various sizes of alpha-tricalcium phosphate particles

The microstructure of bioceramics and its analysis

Development of Magnesium Alloy Scaffolds to Support Biological Myocardial Grafts: A Finite Element Investigation

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