Degradation in vitro and in vivo of β-TCP/MCPM-based premixed calcium phosphate cement

3D-Printed lattice-inspired composites for bone reconstruction

“…In addition, mineralized particles densely covered the surface of DCPA powder particles. The mineralization products were mainly hydroxyapatite (HA), as reported by Yao et al 27 and Trofimchuk et al . 40 The calcium-to-phosphorus ratio of DCPA was close to 1 and that of HA was close to 1.67.…”

“…Literature studies have shown that DCPA has excellent mineralization ability and biocompatibility. 27,29 It can be seen from the figure that with the increase of the DCPA content, more fine mineralized particles were formed on the surface of the scaffold (Fig. 10a–e).…”

“…21–23 Previous studies have shown that calcium hydrogen phosphate is one of the ideal inorganic bone repair materials. 24–26 Yao et al 27 found that calcium phosphate bone cement exhibited good biodegradability, but its mechanical strength decreased significantly during the aging process. Eleni et al 28 prepared a composite material composed of calcium hydrogen phosphate dihydrate (DCPD) and type II collagen.…”

Tackling current production of HAp and HAp-driven biomaterials

“…On the other hand, the degradation rate of b-TCP can range from several weeks to several months, with the material gradually dissolving and being replaced by new bone tissue. 117,118 As a result of the greater degradation rate, b-TCP is usually selected to develop 3D scaffolds that can effectively control BMP-2 release. 12,112,113,119,120 Moreover, the incorporation of BMP-2 leads to the formation of new bone with denser connective tissue and well-supplied with cellular components (Fig.…”

Simultaneous Regulation of the Mechanical/Osteogenic Capacity of Brushite Calcium Phosphate Cement by Incorporating with Poly(ethylene glycol) Dicarboxylic Acid

“…Shu et al prepared brushite CPC with PEG and investigated the degradation, mechanical property, and phase conversion in vitro. 35 Bose et al evaluated the effects of PEG on the compressive strength and biocompatibility of brushite cement. 33 Although, ALP activity, which was closely correlated with promoted osteoblast differentiation, was enhanced in the above-mentioned studies, the compressive strength of CPC with PEG additive was decreased.…”